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DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS

J. Andrew Williams, Ruth Hyland, Barry C. Jones, Dennis A. Smith, Susan Hurst, Theunis C. Goosen, Vincent Peterkin, Jeffrey R. Koup and Simon E. Ball
Drug Metabolism and Disposition November 2004, 32 (11) 1201-1208; DOI: https://doi.org/10.1124/dmd.104.000794

Article Information

vol. 32 no. 11 1201-1208
DOI 
https://doi.org/10.1124/dmd.104.000794
PubMed 
15304429
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 1, 2004
  • Accepted August 9, 2004
  • Published online October 13, 2004.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. J. Andrew Williams,
  2. Ruth Hyland,
  3. Barry C. Jones,
  4. Dennis A. Smith,
  5. Susan Hurst,
  6. Theunis C. Goosen,
  7. Vincent Peterkin,
  8. Jeffrey R. Koup and
  9. Simon E. Ball
  1. Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Ann Arbor, Michigan (J.A.W, S.H., T.C.G., V.P., J.R.K., S.E.B.), and Sandwich, Kent, United Kingdom (R.H., B.C.G., D.A.S.)
  1. Address correspondence to:
    J. Andrew Williams, Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105. E-mail: james.williams2{at}pfizer.com
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OtherMINIREVIEWS

DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS

J. Andrew Williams, Ruth Hyland, Barry C. Jones, Dennis A. Smith, Susan Hurst, Theunis C. Goosen, Vincent Peterkin, Jeffrey R. Koup and Simon E. Ball
Drug Metabolism and Disposition November 1, 2004, 32 (11) 1201-1208; DOI: https://doi.org/10.1124/dmd.104.000794
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