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DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS

J. Andrew Williams, Ruth Hyland, Barry C. Jones, Dennis A. Smith, Susan Hurst, Theunis C. Goosen, Vincent Peterkin, Jeffrey R. Koup and Simon E. Ball
Drug Metabolism and Disposition November 2004, 32 (11) 1201-1208; DOI: https://doi.org/10.1124/dmd.104.000794
J. Andrew Williams
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Ruth Hyland
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Barry C. Jones
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Dennis A. Smith
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Susan Hurst
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Theunis C. Goosen
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Vincent Peterkin
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Jeffrey R. Koup
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Article Information

vol. 32 no. 11 1201-1208
DOI 
https://doi.org/10.1124/dmd.104.000794
PubMed 
15304429

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 1, 2004
  • Accepted August 9, 2004
  • Published online October 13, 2004.

Article Versions

  • Earlier version (August 10, 2004 - 07:11).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. J. Andrew Williams,
  2. Ruth Hyland,
  3. Barry C. Jones,
  4. Dennis A. Smith,
  5. Susan Hurst,
  6. Theunis C. Goosen,
  7. Vincent Peterkin,
  8. Jeffrey R. Koup and
  9. Simon E. Ball
  1. Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Ann Arbor, Michigan (J.A.W, S.H., T.C.G., V.P., J.R.K., S.E.B.), and Sandwich, Kent, United Kingdom (R.H., B.C.G., D.A.S.)
  1. Address correspondence to:
    J. Andrew Williams, Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105. E-mail: james.williams2{at}pfizer.com
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Drug Metabolism and Disposition: 32 (11)
Drug Metabolism and Disposition
Vol. 32, Issue 11
1 Nov 2004
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DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
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OtherMINIREVIEWS

DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS

J. Andrew Williams, Ruth Hyland, Barry C. Jones, Dennis A. Smith, Susan Hurst, Theunis C. Goosen, Vincent Peterkin, Jeffrey R. Koup and Simon E. Ball
Drug Metabolism and Disposition November 1, 2004, 32 (11) 1201-1208; DOI: https://doi.org/10.1124/dmd.104.000794

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DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS

J. Andrew Williams, Ruth Hyland, Barry C. Jones, Dennis A. Smith, Susan Hurst, Theunis C. Goosen, Vincent Peterkin, Jeffrey R. Koup and Simon E. Ball
Drug Metabolism and Disposition November 1, 2004, 32 (11) 1201-1208; DOI: https://doi.org/10.1124/dmd.104.000794
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    • Abstract
    • Clinical Relevance of Cytochrome P450 versus UDP-Glucuronosyltransferase Inhibition in Vitro?
    • Exposure (AUCi/AUC) Ratios >2 for UGT Substrates: Absence of Evidence?
    • Exposure (AUCi/AUC) Ratios >2 for UGT Substrates: Evidence of Absence
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