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DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS

J. Andrew Williams, Ruth Hyland, Barry C. Jones, Dennis A. Smith, Susan Hurst, Theunis C. Goosen, Vincent Peterkin, Jeffrey R. Koup and Simon E. Ball
Drug Metabolism and Disposition November 2004, 32 (11) 1201-1208; DOI: https://doi.org/10.1124/dmd.104.000794
J. Andrew Williams
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Ruth Hyland
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Barry C. Jones
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Dennis A. Smith
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Susan Hurst
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Theunis C. Goosen
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Vincent Peterkin
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Jeffrey R. Koup
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Simon E. Ball
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Drug Metabolism and Disposition: 32 (11)
Drug Metabolism and Disposition
Vol. 32, Issue 11
1 Nov 2004
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DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
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OtherMINIREVIEWS

DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS

J. Andrew Williams, Ruth Hyland, Barry C. Jones, Dennis A. Smith, Susan Hurst, Theunis C. Goosen, Vincent Peterkin, Jeffrey R. Koup and Simon E. Ball
Drug Metabolism and Disposition November 1, 2004, 32 (11) 1201-1208; DOI: https://doi.org/10.1124/dmd.104.000794

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OtherMINIREVIEWS

DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS

J. Andrew Williams, Ruth Hyland, Barry C. Jones, Dennis A. Smith, Susan Hurst, Theunis C. Goosen, Vincent Peterkin, Jeffrey R. Koup and Simon E. Ball
Drug Metabolism and Disposition November 1, 2004, 32 (11) 1201-1208; DOI: https://doi.org/10.1124/dmd.104.000794
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    • Abstract
    • Clinical Relevance of Cytochrome P450 versus UDP-Glucuronosyltransferase Inhibition in Vitro?
    • Exposure (AUCi/AUC) Ratios >2 for UGT Substrates: Absence of Evidence?
    • Exposure (AUCi/AUC) Ratios >2 for UGT Substrates: Evidence of Absence
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