MECHANISM-BASED INACTIVATION OF CYP2D6 BY METHYLENEDIOXYMETHAMPHETAMINE

Academic Unit of Clinical Pharmacology, Pharmacokinetics & Pharmacogenetics Group, Division of Clinical Sciences (South), University of Sheffield, United Kingdom (A.H., M.S.L., S.W.E., G.T.T., A.R.-H); and Simcyp Limited, Blades Enterprise Centre, Sheffield, United Kingdom (K.R.Y., G.T.T., A.R.-H.)

Address correspondence to:
Dr. A. Rostami-Hodjegan, Clinical Pharmacology, Floor L, Royal Hallamshire Hospital, Sheffield S10 2JF, UK. E-mail: A.rostami{at}sheffield.ac.uk

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2004 to January 2021

	Abstract	Full	Pdf
Aug 2004	32	0	53
Sep 2004	63	0	123
Oct 2004	191	81	186
Nov 2004	91	112	99
Dec 2004	87	68	49
Jan 2005	57	66	35
Feb 2005	41	74	58
Mar 2005	22	63	30
Apr 2005	16	67	34
May 2005	28	66	23
Jun 2005	17	48	23
Jul 2005	19	53	13
Aug 2005	9	52	20
Sep 2005	15	48	31
Oct 2005	14	38	20
Nov 2005	24	42	43
Dec 2005	7	47	32
Jan 2006	5	28	16
Feb 2006	4	32	17
Mar 2006	17	34	27
Apr 2006	6	32	27
May 2006	4	35	23
Jun 2006	16	49	30
Jul 2006	6	27	22
Aug 2006	7	17	14
Sep 2006	7	21	9
Oct 2006	14	44	33
Nov 2006	14	36	25
Dec 2006	4	24	18
Jan 2007	6	36	24
Feb 2007	14	26	27
Mar 2007	6	23	23
Apr 2007	9	14	12
May 2007	1	26	25
Jun 2007	10	20	23
Jul 2007	3	23	20
Aug 2007	8	21	12
Sep 2007	7	24	15
Oct 2007	18	18	28
Nov 2007	14	24	31
Dec 2007	8	13	19
Jan 2008	14	10	20
Feb 2008	8	10	25
Mar 2008	13	8	25
Apr 2008	16	12	29
May 2008	26	13	30
Jun 2008	20	25	40
Jul 2008	40	12	50
Aug 2008	45	10	56
Sep 2008	33	24	49
Oct 2008	32	19	52
Nov 2008	40	16	51
Dec 2008	41	3	48
Jan 2009	30	18	46
Feb 2009	26	15	43
Mar 2009	32	12	41
Apr 2009	32	12	58
May 2009	33	8	39
Jun 2009	38	12	42
Jul 2009	36	6	72
Aug 2009	35	14	39
Sep 2009	40	5	35
Oct 2009	50	7	51
Nov 2009	37	6	35
Dec 2009	30	5	26
Jan 2010	19	6	12
Feb 2010	19	5	8
Mar 2010	22	12	16
Apr 2010	15	41	21
May 2010	15	17	8
Jun 2010	18	21	12
Jul 2010	3	14	6
Aug 2010	18	15	9
Sep 2010	21	38	17
Oct 2010	17	22	7
Nov 2010	36	20	9
Dec 2010	37	20	5
Jan 2011	34	24	7
Feb 2011	35	14	7
Mar 2011	27	9	11
Apr 2011	30	7	8
May 2011	15	8	36
Jun 2011	21	6	24
Jul 2011	21	8	32
Aug 2011	16	20	37
Sep 2011	35	35	36
Oct 2011	31	23	39
Nov 2011	49	20	28
Dec 2011	26	9	27
Jan 2012	45	36	49
Feb 2012	34	11	22
Mar 2012	51	49	35
Apr 2012	29	34	44
May 2012	23	30	21
Jun 2012	22	21	17
Jul 2012	21	33	12
Aug 2012	45	29	26
Sep 2012	39	50	35
Oct 2012	37	32	20
Nov 2012	41	25	22
Dec 2012	35	15	6
Jan 2013	47	79	23
Feb 2013	39	35	18
Mar 2013	57	32	16
Apr 2013	58	35	15
May 2013	34	32	8
Jun 2013	7	21	4
Jul 2013	24	18	9
Aug 2013	16	34	10
Sep 2013	42	67	32
Oct 2013	22	12	6
Nov 2013	16	22	7
Dec 2013	12	18	9
Jan 2014	16	25	13
Feb 2014	38	17	6
Mar 2014	30	22	6
Apr 2014	29	16	15
May 2014	28	36	13
Jun 2014	25	22	1
Jul 2014	21	32	7
Aug 2014	10	25	5
Sep 2014	17	36	16
Oct 2014	17	9	8
Nov 2014	21	16	5
Dec 2014	12	25	9
Jan 2015	26	12	9
Feb 2015	20	31	8
Mar 2015	22	8	6
Apr 2015	21	13	7
May 2015	17	24	11
Jun 2015	24	25	5
Jul 2015	15	19	11
Aug 2015	15	13	4
Sep 2015	26	21	6
Oct 2015	24	16	9
Nov 2015	18	16	13
Dec 2015	14	7	2
Jan 2016	27	15	14
Feb 2016	15	21	16
Mar 2016	16	21	13
Apr 2016	17	19	17
May 2016	7	25	9
Jun 2016	16	25	7
Jul 2016	11	26	8
Aug 2016	11	15	5
Sep 2016	5	27	5
Oct 2016	5	22	4
Nov 2016	8	19	3
Dec 2016	2	40	16
Jan 2017	2	25	6
Feb 2017	4	23	1
Mar 2017	2	28	4
Apr 2017	3	17	4
May 2017	3	23	2
Jun 2017	0	15	3
Jul 2017	1	23	1
Aug 2017	0	25	2
Sep 2017	0	32	14
Oct 2017	0	35	7
Nov 2017	3	28	4
Dec 2017	1	16	4
Jan 2018	4	27	7
Feb 2018	0	17	6
Mar 2018	1	25	11
Apr 2018	1	25	9
May 2018	0	40	9
Jun 2018	0	30	5
Jul 2018	0	23	8
Aug 2018	0	22	10
Sep 2018	0	39	16
Oct 2018	0	26	10
Nov 2018	1	36	13
Dec 2018	12	25	5
Jan 2019	26	9	10
Feb 2019	9	1	9
Mar 2019	16	0	4
Apr 2019	13	2	7
May 2019	16	1	2
Jun 2019	6	0	5
Jul 2019	10	1	0
Aug 2019	9	2	3
Sep 2019	33	0	2
Oct 2019	33	5	6
Nov 2019	23	0	1
Dec 2019	19	8	2
Jan 2020	19	5	8
Feb 2020	11	0	2
Mar 2020	17	9	3
Apr 2020	8	1	0
May 2020	16	0	1
Jun 2020	10	1	0
Jul 2020	15	1	0
Aug 2020	16	0	4
Sep 2020	20	10	6
Oct 2020	13	3	1
Nov 2020	20	1	1
Dec 2020	26	4	1
Jan 2021	65	14	14