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Research ArticleArticle

HEPATIC MICROSOME STUDIES ARE INSUFFICIENT TO CHARACTERIZE IN VIVO HEPATIC METABOLIC CLEARANCE AND METABOLIC DRUG-DRUG INTERACTIONS: STUDIES OF DIGOXIN METABOLISM IN PRIMARY RAT HEPATOCYTES VERSUS MICROSOMES

Justine L. Lam and Leslie Z. Benet
Drug Metabolism and Disposition November 2004, 32 (11) 1311-1316; DOI: https://doi.org/10.1124/dmd.32.11.1311

Article Information

vol. 32 no. 11 1311-1316
DOI 
https://doi.org/10.1124/dmd.32.11.1311
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 1, 2003
  • Accepted August 17, 2004
  • Published online October 13, 2004.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Justine L. Lam and
  2. Leslie Z. Benet
  1. Department of Biopharmaceutical Sciences, University of California, San Francisco
  1. Address correspondence to:
    Dr. Leslie Z. Benet, Professor, Department of Biopharmaceutical Sciences, University of California San Francisco, 533 Parnassus, Room U-68, San Francisco, CA 94143-0446. E-mail: benet{at}itsa.ucsf.edu
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HEPATIC MICROSOME STUDIES ARE INSUFFICIENT TO CHARACTERIZE IN VIVO HEPATIC METABOLIC CLEARANCE AND METABOLIC DRUG-DRUG INTERACTIONS: STUDIES OF DIGOXIN METABOLISM IN PRIMARY RAT HEPATOCYTES VERSUS MICROSOMES

Justine L. Lam and Leslie Z. Benet
Drug Metabolism and Disposition November 1, 2004, 32 (11) 1311-1316; DOI: https://doi.org/10.1124/dmd.32.11.1311
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