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Drug Metabolism & Disposition

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Table of Contents

December 01, 2004; Volume 32,Issue 12

Short Communications

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    MULTIPLE NIGHT-TIME DOSES OF VALERIAN (Valeriana officinalis) HAD MINIMAL EFFECTS ON CYP3A4 ACTIVITY AND NO EFFECT ON CYP2D6 ACTIVITY IN HEALTHY VOLUNTEERS
    Jennifer L. Donovan, C. Lindsay DeVane, Kenneth D. Chavin, Jun-Sheng Wang, Bryan B. Gibson, Holly A. Gefroh and John S. Markowitz
    Drug Metabolism and Disposition December 2004, 32 (12) 1333-1336; DOI: https://doi.org/10.1124/dmd.104.001164
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    DIFFERENCES IN FMO2*1 ALLELIC FREQUENCY BETWEEN HISPANICS OF PUERTO RICAN AND MEXICAN DESCENT
    Sharon K. Krueger, Lisbeth K. Siddens, Sarah R. Martin, Zhen Yu, Clifford B. Pereira, Erwin T. Cabacungan, Ronald N. Hines, Kristin G. Ardlie, Judy L. Raucy and David E. Williams
    Drug Metabolism and Disposition December 2004, 32 (12) 1337-1340; DOI: https://doi.org/10.1124/dmd.104.001099
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    HAPLOTYPE STRUCTURE AND ALLELE FREQUENCIES OF CYP2B6 IN A KOREAN POPULATION
    Joo-Youn Cho, Hyeong-Seok Lim, Jae-Yong Chung, Kyung-Sang Yu, Jung-Ryul Kim, Sang-Goo Shin and In-Jin Jang
    Drug Metabolism and Disposition December 2004, 32 (12) 1341-1344; DOI: https://doi.org/10.1124/dmd.104.001107

Articles

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    DETECTION OF GLUTATHIONE CONJUGATES DERIVED FROM 4-IPOMEANOL METABOLISM IN BILE OF RATS BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
    Teresa M. Alvarez-Diez and Jiang Zheng
    Drug Metabolism and Disposition December 2004, 32 (12) 1345-1350; DOI: https://doi.org/10.1124/dmd.104.000406
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    IDENTIFICATION AND CHARACTERIZATION OF POTENT CYP3A4 INHIBITORS IN SCHISANDRA FRUIT EXTRACT
    Hiroshi Iwata, Yasuhiro Tezuka, Shigetoshi Kadota, Akira Hiratsuka and Tadashi Watabe
    Drug Metabolism and Disposition December 2004, 32 (12) 1351-1358; DOI: https://doi.org/10.1124/dmd.104.000646
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    THE CHIMPANZEE (PAN TROGLODYTES) AS A PHARMACOKINETIC MODEL FOR SELECTION OF DRUG CANDIDATES: MODEL CHARACTERIZATION AND APPLICATION
    Harvey Wong, Scott J. Grossman, Stephen A. Bai, Sharon Diamond, Matthew R. Wright, James E. Grace, Mingxin Qian, Kan He, Krishnaswamy Yeleswaram and David D. Christ
    Drug Metabolism and Disposition December 2004, 32 (12) 1359-1369; DOI: https://doi.org/10.1124/dmd.104.000943
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    EFFECTS OF AVASIMIBE ON CYTOCHROME P450 2C9 EXPRESSION IN VITRO AND IN VIVO
    Jasminder Sahi, Ralph H. Stern, Mark A. Milad, Kelly A. Rose, Gordon Gibson, Xianxian Zheng, Linda Stilgenbauer, Nalini Sadagopan, Summer Jolley, Darryl Gilbert and Edward L. LeCluyse
    Drug Metabolism and Disposition December 2004, 32 (12) 1370-1376; DOI: https://doi.org/10.1124/dmd.104.000208
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    HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS
    Thomas Walle, Faye Hsieh, Mark H. DeLegge, John E. Oatis and U. Kristina Walle
    Drug Metabolism and Disposition December 2004, 32 (12) 1377-1382; DOI: https://doi.org/10.1124/dmd.104.000885
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    MECHANISM OF THE DRUG INTERACTION BETWEEN VALPROIC ACID AND CARBAPENEM ANTIBIOTICS IN MONKEYS AND RATS
    Yoshitsugu Nakajima, Minoru Mizobuchi, Masahiro Nakamura, Hidetoshi Takagi, Haruhisa Inagaki, Goro Kominami, Masahiro Koike and Toshiro Yamaguchi
    Drug Metabolism and Disposition December 2004, 32 (12) 1383-1391; DOI: https://doi.org/10.1124/dmd.104.000661
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    FLUORINATED 2-(4-AMINO-3-METHYLPHENYL)BENZOTHIAZOLES INDUCE CYP1A1 EXPRESSION, BECOME METABOLIZED, AND BIND TO MACROMOLECULES IN SENSITIVE HUMAN CANCER CELLS
    Eileen Brantley, Valentina Trapani, Michael C. Alley, Curtis D. Hose, Tracey D. Bradshaw, Malcolm F. G. Stevens, Edward A. Sausville and Sherman F. Stinson
    Drug Metabolism and Disposition December 2004, 32 (12) 1392-1401; DOI: https://doi.org/10.1124/dmd.104.001057
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    EXPRESSION OF HUMAN CYTOCHROMES P450 IN CHIMERIC MICE WITH HUMANIZED LIVER
    Miki Katoh, Tomohito Matsui, Miki Nakajima, Chise Tateno, Miho Kataoka, Yoshinori Soeno, Toru Horie, Kazuhide Iwasaki, Katsutoshi Yoshizato and Tsuyoshi Yokoi
    Drug Metabolism and Disposition December 2004, 32 (12) 1402-1410; DOI: https://doi.org/10.1124/dmd.104.001347
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    UTILITY OF RECOMBINANT ENZYME KINETICS IN PREDICTION OF HUMAN CLEARANCE: IMPACT OF VARIABILITY, CYP3A5, AND CYP2C19 ON CYP3A4 PROBE SUBSTRATES
    Aleksandra Galetin, Caroline Brown, David Hallifax, Kiyomi Ito and J. Brian Houston
    Drug Metabolism and Disposition December 2004, 32 (12) 1411-1420; DOI: https://doi.org/10.1124/dmd.104.000844
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    THE RATE OF GASTRIC EMPTYING DETERMINES THE TIMING BUT NOT THE EXTENT OF ORAL TACROLIMUS ABSORPTION: SIMULTANEOUS MEASUREMENT OF DRUG EXPOSURE AND GASTRIC EMPTYING BY CARBON-14-OCTANOIC ACID BREATH TEST IN STABLE RENAL ALLOGRAFT RECIPIENTS
    Dirk R. J. Kuypers, Kathleen Claes, P. Evenepoel, B. Maes and Yves Vanrenterghem
    Drug Metabolism and Disposition December 2004, 32 (12) 1421-1425; DOI: https://doi.org/10.1124/dmd.104.001503
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    ASSESSMENT OF CATECHOL INDUCTION AND GLUCURONIDATION IN RAT LIVER MICROSOMES
    Eivor Elovaara, Jouni Mikkola, Leena Luukkanen, Laurence Antonio, Sylvie Fournel-Gigleux, Brian Burchell, Jacques Magdalou and Jyrki Taskinen
    Drug Metabolism and Disposition December 2004, 32 (12) 1426-1433; DOI: https://doi.org/10.1124/dmd.104.000992
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    EVIDENCE OF SIGNIFICANT CONTRIBUTION FROM CYP3A5 TO HEPATIC DRUG METABOLISM
    Weili Huang, Yvonne S. Lin, Donavon J. McConn, Justina C. Calamia, Rheem A. Totah, Nina Isoherranen, Mary Glodowski and Kenneth E. Thummel
    Drug Metabolism and Disposition December 2004, 32 (12) 1434-1445; DOI: https://doi.org/10.1124/dmd.104.001313
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    SHORT-TERM INHIBITORY EFFECTS OF NITRIC OXIDE ON CYTOCHROME P450-MEDIATED DRUG METABOLISM: TIME DEPENDENCY AND REVERSIBILITY PROFILES IN ISOLATED PERFUSED RAT LIVERS
    Ragini Vuppugalla and Reza Mehvar
    Drug Metabolism and Disposition December 2004, 32 (12) 1446-1454; DOI: https://doi.org/10.1124/dmd.104.001487
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    TISSUE DISTRIBUTION OF CONCENTRATIVE AND EQUILIBRATIVE NUCLEOSIDE TRANSPORTERS IN MALE AND FEMALE RATS AND MICE
    Hong Lu, Chuan Chen and Curtis Klaassen
    Drug Metabolism and Disposition December 2004, 32 (12) 1455-1461; DOI: https://doi.org/10.1124/dmd.104.001123
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    CONVERSION OF THE HIV PROTEASE INHIBITOR NELFINAVIR TO A BIOACTIVE METABOLITE BY HUMAN LIVER CYP2C19
    Vandana N. Hirani, Judy L. Raucy and Jerome M. Lasker
    Drug Metabolism and Disposition December 2004, 32 (12) 1462-1467; DOI: https://doi.org/10.1124/dmd.104.001743
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    IN VITRO AND IN VIVO CORRELATION OF THE INHIBITORY EFFECT OF CYCLOSPORIN A ON THE TRANSPORTER-MEDIATED HEPATIC UPTAKE OF CERIVASTATIN IN RATS
    Yoshihisa Shitara, Masaru Hirano, Yasuhisa Adachi, Tomoo Itoh, Hitoshi Sato and Yuichi Sugiyama
    Drug Metabolism and Disposition December 2004, 32 (12) 1468-1475; DOI: https://doi.org/10.1124/dmd.32.12.1468
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    IDENTIFICATION OF THE RABBIT LIVER UDP-GLUCURONOSYLTRANSFERASE CATALYZING THE GLUCURONIDATION OF 4-ETHOXYPHENYLUREA (DULCIN)
    Yoshihiro Uesawa, Adam G. Staines, Audrey O'Sullivan, Kiminori Mohri and Brian Burchell
    Drug Metabolism and Disposition December 2004, 32 (12) 1476-1481; DOI: https://doi.org/10.1124/dmd.104.001206
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    IDENTIFICATION OF GLUTATHIONE-DERIVED METABOLITES FROM AN IP RECEPTOR ANTAGONIST
    William L. Fitch, Pamela W. Berry, Yaping Tu, Ali Tabatabaei, Lee Lowrie, Francisco Lopez-Tapia, Yanzhou Liu, Dov Nitzan, Mohammad R. Masjedizadeh and Aravamuthan Varadarajan
    Drug Metabolism and Disposition December 2004, 32 (12) 1482-1490; DOI: https://doi.org/10.1124/dmd.104.000471
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    METABOLISM AND DISPOSITION OF CALCIMIMETIC AGENT CINACALCET HCL IN HUMANS AND ANIMAL MODELS
    Gondi N. Kumar, Christopher Sproul, Leszek Poppe, Sharon Turner, Mark Gohdes, Hesham Ghoborah, Desmond Padhi and Lorin Roskos
    Drug Metabolism and Disposition December 2004, 32 (12) 1491-1500; DOI: https://doi.org/10.1124/dmd.104.000604
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    INTERACTIONS OF THE STEREOISOMERS OF α-HYDROXYTAMOXIFEN WITH HUMAN HYDROXYSTEROID SULFOTRANSFERASE SULT2A1 AND RAT HYDROXYSTEROID SULFOTRANSFERASE STA
    T. Idil Apak and Michael W. Duffel
    Drug Metabolism and Disposition December 2004, 32 (12) 1501-1508; DOI: https://doi.org/10.1124/dmd.104.000919
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    USE OF A BENZYLOXY-SUBSTITUTED LACTONE CYCLOOXYGENASE-2 INHIBITOR AS A SELECTIVE FLUORESCENT PROBE FOR CYP3A ACTIVITY IN PRIMARY CULTURED RAT AND HUMAN HEPATOCYTES
    Deborah A. Nicoll-Griffith, Nathalie Chauret, Robert Houle, Stephen H. Day, Michelle D'Antoni and José M. Silva
    Drug Metabolism and Disposition December 2004, 32 (12) 1509-1515; DOI: https://doi.org/10.1124/dmd.32.12.1509
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    IDENTIFICATION OF CRITICAL AMINO ACID RESIDUES OF HUMAN CYP2A13 FOR THE METABOLIC ACTIVATION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE, A TOBACCO-SPECIFIC CARCINOGEN
    Xiao-Yang He, Jian Shen, Xinxin Ding, Anthony Y. H. Lu and Jun-Yan Hong
    Drug Metabolism and Disposition December 2004, 32 (12) 1516-1521; DOI: https://doi.org/10.1124/dmd.104.001370

Letters to the Editor

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    PREDICTING THE CLEARANCE OF CYP2C9 SUBSTRATES
    Karen Rowland Yeo, Eleanor M. Howgate, Geoffrey T. Tucker and Amin Rostami-Hodjegan
    Drug Metabolism and Disposition December 2004, 32 (12) 1522; DOI: https://doi.org/10.1124/dmd.104.001792
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    RESPONSE: PREDICTING THE CLEARANCE OF CYP2C9 SUBSTRATES
    Tommy B. Andersson, Eva Bredberg, Hans Ericsson and Helena SjÖberg
    Drug Metabolism and Disposition December 2004, 32 (12) 1523; DOI: https://doi.org/10.1124/dmd.104.002329
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    IN VITRO STUDY OF MYCOPHENOLIC ACID GLUCURONIDATION
    Nicolas Picard and Pierre Marquet
    Drug Metabolism and Disposition December 2004, 32 (12) 1524; DOI: https://doi.org/10.1124/dmd.104.001982
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    RESPONSE TO THE LETTER TO THE EDITOR BY DRS. N. PICARD AND P. MARQUET REGARDING A PUBLICATION: BASU ET AL., DRUG METABOLISM AND DISPOSITION (32:768–773, (2004)
    N. K. Basu, L. Kole, S. Kubota and I. S. Owens
    Drug Metabolism and Disposition December 2004, 32 (12) 1525; DOI: https://doi.org/10.1124/dmd.104.002345
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Drug Metabolism and Disposition: 32 (12)
Drug Metabolism and Disposition
Vol. 32, Issue 12
1 Dec 2004
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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