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Research ArticleArticle

MECHANISM OF THE DRUG INTERACTION BETWEEN VALPROIC ACID AND CARBAPENEM ANTIBIOTICS IN MONKEYS AND RATS

Yoshitsugu Nakajima, Minoru Mizobuchi, Masahiro Nakamura, Hidetoshi Takagi, Haruhisa Inagaki, Goro Kominami, Masahiro Koike and Toshiro Yamaguchi
Drug Metabolism and Disposition December 2004, 32 (12) 1383-1391; DOI: https://doi.org/10.1124/dmd.104.000661
Yoshitsugu Nakajima
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Minoru Mizobuchi
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Masahiro Nakamura
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Hidetoshi Takagi
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Haruhisa Inagaki
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Goro Kominami
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Masahiro Koike
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Toshiro Yamaguchi
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Abstract

The Ministry of Health and Welfare, Japan banned coadministration of carbapenems, such as panipenem/betamipron (PAPM), meropenem (MEPM), and valproic acid (VPA) because clinical reports have indicated that the coadministration caused seizures in epileptic patients due to lowered plasma levels of VPA. In this study, we have clarified the mechanism of the drug-drug interaction using PAPM, MEPM, and doripenem [S-4661; (+)-(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-[[(3S,5S)-5-[(sulfamoylamino)methyl]-3-pyrrolidinyl]thio]-1-azabicyclo[3.2.0]hept-2-ene-2-caboxylic acid monohydrate], a newly synthesized carbapenem. In vitro experiments using monkey liver slices suggested that the apparent synthetic rate of VPA glucuronide (VPA-G) increased in the presence of carbapenems. However, no such increase was observed in the experiment using monkey liver microsomes. Although no increase of uridine 5′-diphosphate d-glucuronic acid was found in monkey liver slices in the presence of carbapenems, potent inhibitory activity of carbapenems for the hydrolysis of VPA-G was found in monkey and rat liver homogenate. In vivo hydrolysis of VPA-G was clearly shown by the existence of VPA in plasma after dosing of VPA-G to rats, and its inhibition by carbapenems was also clearly shown by the negligible levels of VPA in rat plasma after coadministration of carbapenems and VPA-G. These results clearly indicate one of the important causes of drug interaction as follows: carbapenems would inhibit the hydrolytic enzyme, which is involved in the hydrolysis of VPA-G to VPA, resulting in a decrease of plasma concentration of VPA.

Footnotes

  • This work has been presented at the 10th North American ISSX Meeting in Indianapolis on 24 October 2000.

  • doi:10.1124/dmd.104.000661.

  • ABBREVIATIONS: PAPM, panipenem/betamipron; MEPM, meropenem; VPA, valproic acid; S-4661, doripenem [(+)-(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-[[(3S,5S)-5-[(sulfamoylamino)methyl]-3-pyrrolidinyl]thio]-1-azabicyclo[3.2.0]hept-2-ene-2-caboxylic acid monohydrate]; VPA-G, valproic acid glucuronide; TLC, thin-layer chromatography; GLC, gas-liquid chromatography; KRB, Krebs-Ringer bicarbonate buffer; UDPGA, uridine 5′-diphosphate d-glucuronic acid; MRT, mean residence time.

    • Received May 17, 2004.
    • Accepted September 1, 2004.
  • The American Society for Pharmacology and Experimental Therapeutics
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Drug Metabolism and Disposition: 32 (12)
Drug Metabolism and Disposition
Vol. 32, Issue 12
1 Dec 2004
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Research ArticleArticle

MECHANISM OF THE DRUG INTERACTION BETWEEN VALPROIC ACID AND CARBAPENEM ANTIBIOTICS IN MONKEYS AND RATS

Yoshitsugu Nakajima, Minoru Mizobuchi, Masahiro Nakamura, Hidetoshi Takagi, Haruhisa Inagaki, Goro Kominami, Masahiro Koike and Toshiro Yamaguchi
Drug Metabolism and Disposition December 1, 2004, 32 (12) 1383-1391; DOI: https://doi.org/10.1124/dmd.104.000661

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Research ArticleArticle

MECHANISM OF THE DRUG INTERACTION BETWEEN VALPROIC ACID AND CARBAPENEM ANTIBIOTICS IN MONKEYS AND RATS

Yoshitsugu Nakajima, Minoru Mizobuchi, Masahiro Nakamura, Hidetoshi Takagi, Haruhisa Inagaki, Goro Kominami, Masahiro Koike and Toshiro Yamaguchi
Drug Metabolism and Disposition December 1, 2004, 32 (12) 1383-1391; DOI: https://doi.org/10.1124/dmd.104.000661
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