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Drug Metabolism & Disposition

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Table of Contents

February 01, 2004; Volume 32,Issue 2

Short Communications

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    DIFFERENTIAL REGULATION OF THE HUMAN CYP3A4 PROMOTER IN TRANSGENIC MICE AND RATS
    Weisheng Zhang, Anthony F. Purchio, Richard Coffee and David B. West
    Drug Metabolism and Disposition February 2004, 32 (2) 163-167; DOI: https://doi.org/10.1124/dmd.32.2.163
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    EFFECT OF RECOMBINANT INTERLEUKIN-2 PRETREATMENT ON ORAL AND INTRAVENOUS DIGOXIN PHARMACOKINETICS AND P-GLYCOPROTEIN ACTIVITY IN MICE
    Vincent Castagne, Laurence Bonhomme-Faivre, Saik Urien, Makram Ben Reguiga, Mireille Soursac, Francois Gimenez and Robert Farinotti
    Drug Metabolism and Disposition February 2004, 32 (2) 168-171; DOI: https://doi.org/10.1124/dmd.32.2.168

Articles

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    DEVELOPMENT OF AN IN VIVO PRECLINICAL SCREEN MODEL TO ESTIMATE ABSORPTION AND FIRST-PASS HEPATIC EXTRACTION OF XENOBIOTICS. II. USE OF KETOCONAZOLE TO IDENTIFY P-GLYCOPROTEIN/CYP3A-LIMITED BIOAVAILABILITY IN THE MONKEY
    Keith W. Ward, Gary J. Stelman, Jayme A. Morgan, Kelli S. Zeigler, Leonard M. Azzarano, Jonathan R. Kehler, Jeanelle E. McSurdy-Freed, Joel W. Proksch and Brian R. Smith
    Drug Metabolism and Disposition February 2004, 32 (2) 172-177; DOI: https://doi.org/10.1124/dmd.32.2.172
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    IDENTIFICATION OF A HYDROXYLAMINE GLUCURONIDE METABOLITE OF AN ORAL HYPOGLYCEMIC AGENT
    Randall R. Miller, George A. Doss and Ralph A. Stearns
    Drug Metabolism and Disposition February 2004, 32 (2) 178-185; DOI: https://doi.org/10.1124/dmd.32.2.178
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    DIFFERENTIAL ENANTIOSELECTIVITY AND PRODUCT-DEPENDENT ACTIVATION AND INHIBITION IN METABOLISM OF VERAPAMIL BY HUMAN CYP3AS
    Lixin Shen, John F. Fitzloff and Chyung S. Cook
    Drug Metabolism and Disposition February 2004, 32 (2) 186-196; DOI: https://doi.org/10.1124/dmd.32.2.186
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    NONLINEAR ORAL PHARMACOKINETICS OF THE α-ANTAGONIST 4-AMINO-5-(4-FLUOROPHENYL)-6,7-DIMETHOXY-2-[4-(MORPHOLINOCARBONYL)-PERHYDRO-1,4-DIAZEPIN-1-YL]QUINOLINE IN HUMANS: USE OF PRECLINICAL DATA TO RATIONALIZE CLINICAL OBSERVATIONS
    Anthony Harrison, Alison Betts, Katherine Fenner, Kevin Beaumont, Alan Edgington, Sarah Roffey, John Davis, Pierre Comby and Paul Morgan
    Drug Metabolism and Disposition February 2004, 32 (2) 197-204; DOI: https://doi.org/10.1124/dmd.32.2.197
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    BIOTRANSFORMATION OF FUCOXANTHINOL INTO AMAROUCIAXANTHIN A IN MICE AND HEPG2 CELLS: FORMATION AND CYTOTOXICITY OF FUCOXANTHIN METABOLITES
    Akira Asai, Tatsuya Sugawara, Hiroshi Ono and Akihiko Nagao
    Drug Metabolism and Disposition February 2004, 32 (2) 205-211; DOI: https://doi.org/10.1124/dmd.32.2.205
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    STEREOSELECTIVE PHARMACOKINETICS OF FLUOXETINE AND NORFLUOXETINE ENANTIOMERS IN PREGNANT SHEEP
    John Kim, K. Wayne Riggs and Dan W. Rurak
    Drug Metabolism and Disposition February 2004, 32 (2) 212-221; DOI: https://doi.org/10.1124/dmd.32.2.212
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    EFFECT OF TOTAL PARENTERAL NUTRITION AND CHOLINE ON HEPATIC FLAVIN-CONTAINING AND CYTOCHROME P-450 MONOOXYGENASE ACTIVITY IN RATS
    John R. Cashman, Virginie Lattard and Jing Lin
    Drug Metabolism and Disposition February 2004, 32 (2) 222-229; DOI: https://doi.org/10.1124/dmd.32.2.222
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    AN EVALUATION METHOD FOR NONLINEAR LOCAL DISPOSITION IN RAT LIVER AND KIDNEY
    Takako Kato, Kiyoshi Yamaoka and Yoshinobu Takakura
    Drug Metabolism and Disposition February 2004, 32 (2) 230-234; DOI: https://doi.org/10.1124/dmd.32.2.230
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    INVOLVEMENT OF HUMAN HEPATIC UGT1A1, UGT2B4, AND UGT2B7 IN THE GLUCURONIDATION OF CARVEDILOL
    Akiko Ohno, Yoshiro Saito, Nobumitsu Hanioka, Hideto Jinno, Mayumi Saeki, Masanori Ando, Shogo Ozawa and Jun-ichi Sawada
    Drug Metabolism and Disposition February 2004, 32 (2) 235-239; DOI: https://doi.org/10.1124/dmd.32.2.235
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    POLYMORPHIC EXPRESSION OF CYP1A2 LEADING TO INTERINDIVIDUAL VARIABILITY IN METABOLISM OF A NOVEL BENZODIAZEPINE RECEPTOR PARTIAL INVERSE AGONIST IN DOGS
    Masashi Mise, Seiji Yadera, Michiaki Matsuda, Takanori Hashizume, Satoshi Matsumoto, Yoshiaki Terauchi and Toshihiko Fujii
    Drug Metabolism and Disposition February 2004, 32 (2) 240-245; DOI: https://doi.org/10.1124/dmd.32.2.240
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    THE METABOLIC DISPOSITION OF APREPITANT, A SUBSTANCE P RECEPTOR ANTAGONIST, IN RATS AND DOGS
    Su-Er W. Huskey, Brian J. Dean, George A. Doss, Zhen Wang, Cornelis E.C.A. Hop, Reza Anari, Paul E. Finke, Albert J. Robichaud, Minghua Zhang, Bonnie Wang, John R. Strauss, Paul K. Cunningham, William P. Feeney, Ronald B. Franklin, Thomas A. Baillie and Shuet-Hing L. Chiu
    Drug Metabolism and Disposition February 2004, 32 (2) 246-258; DOI: https://doi.org/10.1124/dmd.32.2.246
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    PREDICTION OF CYTOCHROME P450 3A INHIBITION BY VERAPAMIL ENANTIOMERS AND THEIR METABOLITES
    Ying-Hong Wang, David R. Jones and Stephen D. Hall
    Drug Metabolism and Disposition February 2004, 32 (2) 259-266; DOI: https://doi.org/10.1124/dmd.32.2.259
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    IDENTIFICATION OF HUMAN UDP-GLUCURONOSYLTRANSFERASE ENZYME(S) RESPONSIBLE FOR THE GLUCURONIDATION OF POSACONAZOLE (NOXAFIL)
    Anima Ghosal, Neil Hapangama, Yuan Yuan, Joana Achanfuo-Yeboah, Robert Iannucci, Swapan Chowdhury, Kevin Alton, James E. Patrick and Shmuel Zbaida
    Drug Metabolism and Disposition February 2004, 32 (2) 267-271; DOI: https://doi.org/10.1124/dmd.32.2.267
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    METABOLISM OF 8-PRENYLNARINGENIN, A POTENT PHYTOESTROGEN FROM HOPS (HUMULUS LUPULUS), BY HUMAN LIVER MICROSOMES
    Dejan Nikolic, Yongmei Li, Lucas R. Chadwick, Simonida Grubjesic, Pia Schwab, Peter Metz and Richard B. van Breemen
    Drug Metabolism and Disposition February 2004, 32 (2) 272-279; DOI: https://doi.org/10.1124/dmd.32.2.272

Erratum

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    CORRECTION TO “TWO NEW POLYMORPHISMS OF THE FMO3 GENE IN CAUCASIAN AND AFRICAN-AMERICAN POPULATIONS: COMPARATIVE GENETIC AND FUNCTIONAL STUDIES”
    Drug Metabolism and Disposition February 2004, 32 (2) 280; DOI: https://doi.org/10.1124/dmd.32.2.280
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Drug Metabolism and Disposition: 32 (2)
Drug Metabolism and Disposition
Vol. 32, Issue 2
1 Feb 2004
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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