Table of Contents

Articles

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  DEVELOPMENT OF AN IN VIVO PRECLINICAL SCREEN MODEL TO ESTIMATE ABSORPTION AND FIRST-PASS HEPATIC EXTRACTION OF XENOBIOTICS. II. USE OF KETOCONAZOLE TO IDENTIFY P-GLYCOPROTEIN/CYP3A-LIMITED BIOAVAILABILITY IN THE MONKEY

  Keith W. Ward, Gary J. Stelman, Jayme A. Morgan, Kelli S. Zeigler, Leonard M. Azzarano, Jonathan R. Kehler, Jeanelle E. McSurdy-Freed, Joel W. Proksch and Brian R. Smith

  Drug Metabolism and Disposition February 2004, 32 (2) 172-177; DOI: https://doi.org/10.1124/dmd.32.2.172
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  IDENTIFICATION OF A HYDROXYLAMINE GLUCURONIDE METABOLITE OF AN ORAL HYPOGLYCEMIC AGENT

  Randall R. Miller, George A. Doss and Ralph A. Stearns

  Drug Metabolism and Disposition February 2004, 32 (2) 178-185; DOI: https://doi.org/10.1124/dmd.32.2.178
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  DIFFERENTIAL ENANTIOSELECTIVITY AND PRODUCT-DEPENDENT ACTIVATION AND INHIBITION IN METABOLISM OF VERAPAMIL BY HUMAN CYP3AS

  Lixin Shen, John F. Fitzloff and Chyung S. Cook

  Drug Metabolism and Disposition February 2004, 32 (2) 186-196; DOI: https://doi.org/10.1124/dmd.32.2.186
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  NONLINEAR ORAL PHARMACOKINETICS OF THE α-ANTAGONIST 4-AMINO-5-(4-FLUOROPHENYL)-6,7-DIMETHOXY-2-[4-(MORPHOLINOCARBONYL)-PERHYDRO-1,4-DIAZEPIN-1-YL]QUINOLINE IN HUMANS: USE OF PRECLINICAL DATA TO RATIONALIZE CLINICAL OBSERVATIONS

  Anthony Harrison, Alison Betts, Katherine Fenner, Kevin Beaumont, Alan Edgington, Sarah Roffey, John Davis, Pierre Comby and Paul Morgan

  Drug Metabolism and Disposition February 2004, 32 (2) 197-204; DOI: https://doi.org/10.1124/dmd.32.2.197
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  BIOTRANSFORMATION OF FUCOXANTHINOL INTO AMAROUCIAXANTHIN A IN MICE AND HEPG2 CELLS: FORMATION AND CYTOTOXICITY OF FUCOXANTHIN METABOLITES

  Akira Asai, Tatsuya Sugawara, Hiroshi Ono and Akihiko Nagao

  Drug Metabolism and Disposition February 2004, 32 (2) 205-211; DOI: https://doi.org/10.1124/dmd.32.2.205
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  STEREOSELECTIVE PHARMACOKINETICS OF FLUOXETINE AND NORFLUOXETINE ENANTIOMERS IN PREGNANT SHEEP

  John Kim, K. Wayne Riggs and Dan W. Rurak

  Drug Metabolism and Disposition February 2004, 32 (2) 212-221; DOI: https://doi.org/10.1124/dmd.32.2.212
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  EFFECT OF TOTAL PARENTERAL NUTRITION AND CHOLINE ON HEPATIC FLAVIN-CONTAINING AND CYTOCHROME P-450 MONOOXYGENASE ACTIVITY IN RATS

  John R. Cashman, Virginie Lattard and Jing Lin

  Drug Metabolism and Disposition February 2004, 32 (2) 222-229; DOI: https://doi.org/10.1124/dmd.32.2.222
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  AN EVALUATION METHOD FOR NONLINEAR LOCAL DISPOSITION IN RAT LIVER AND KIDNEY

  Takako Kato, Kiyoshi Yamaoka and Yoshinobu Takakura

  Drug Metabolism and Disposition February 2004, 32 (2) 230-234; DOI: https://doi.org/10.1124/dmd.32.2.230
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  INVOLVEMENT OF HUMAN HEPATIC UGT1A1, UGT2B4, AND UGT2B7 IN THE GLUCURONIDATION OF CARVEDILOL

  Akiko Ohno, Yoshiro Saito, Nobumitsu Hanioka, Hideto Jinno, Mayumi Saeki, Masanori Ando, Shogo Ozawa and Jun-ichi Sawada

  Drug Metabolism and Disposition February 2004, 32 (2) 235-239; DOI: https://doi.org/10.1124/dmd.32.2.235
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  POLYMORPHIC EXPRESSION OF CYP1A2 LEADING TO INTERINDIVIDUAL VARIABILITY IN METABOLISM OF A NOVEL BENZODIAZEPINE RECEPTOR PARTIAL INVERSE AGONIST IN DOGS

  Masashi Mise, Seiji Yadera, Michiaki Matsuda, Takanori Hashizume, Satoshi Matsumoto, Yoshiaki Terauchi and Toshihiko Fujii

  Drug Metabolism and Disposition February 2004, 32 (2) 240-245; DOI: https://doi.org/10.1124/dmd.32.2.240
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  THE METABOLIC DISPOSITION OF APREPITANT, A SUBSTANCE P RECEPTOR ANTAGONIST, IN RATS AND DOGS

  Su-Er W. Huskey, Brian J. Dean, George A. Doss, Zhen Wang, Cornelis E.C.A. Hop, Reza Anari, Paul E. Finke, Albert J. Robichaud, Minghua Zhang, Bonnie Wang, John R. Strauss, Paul K. Cunningham, William P. Feeney, Ronald B. Franklin, Thomas A. Baillie and Shuet-Hing L. Chiu

  Drug Metabolism and Disposition February 2004, 32 (2) 246-258; DOI: https://doi.org/10.1124/dmd.32.2.246
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  PREDICTION OF CYTOCHROME P450 3A INHIBITION BY VERAPAMIL ENANTIOMERS AND THEIR METABOLITES

  Ying-Hong Wang, David R. Jones and Stephen D. Hall

  Drug Metabolism and Disposition February 2004, 32 (2) 259-266; DOI: https://doi.org/10.1124/dmd.32.2.259
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  IDENTIFICATION OF HUMAN UDP-GLUCURONOSYLTRANSFERASE ENZYME(S) RESPONSIBLE FOR THE GLUCURONIDATION OF POSACONAZOLE (NOXAFIL)

  Anima Ghosal, Neil Hapangama, Yuan Yuan, Joana Achanfuo-Yeboah, Robert Iannucci, Swapan Chowdhury, Kevin Alton, James E. Patrick and Shmuel Zbaida

  Drug Metabolism and Disposition February 2004, 32 (2) 267-271; DOI: https://doi.org/10.1124/dmd.32.2.267
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  METABOLISM OF 8-PRENYLNARINGENIN, A POTENT PHYTOESTROGEN FROM HOPS (HUMULUS LUPULUS), BY HUMAN LIVER MICROSOMES

  Dejan Nikolic, Yongmei Li, Lucas R. Chadwick, Simonida Grubjesic, Pia Schwab, Peter Metz and Richard B. van Breemen

  Drug Metabolism and Disposition February 2004, 32 (2) 272-279; DOI: https://doi.org/10.1124/dmd.32.2.272