Drug Metabolism and Disposition: 32 (3)

March 01, 2004; Volume 32,Issue 3

Symposium Article

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GLUCURONIDATION AND THE UDP-GLUCURONOSYLTRANSFERASES IN HEALTH AND DISEASE
Peter G. Wells, Peter I. Mackenzie, Jayanta Roy Chowdhury, Chantal Guillemette, Philip A. Gregory, Yuji Ishii, Antony J. Hansen, Fay K. Kessler, Perry M. Kim, Namita Roy Chowdhury and Joseph K. Ritter

Drug Metabolism and Disposition March 2004, 32 (3) 281-290; DOI: https://doi.org/10.1124/dmd.32.3.281

Short Communication

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INVOLVEMENT OF ORGANIC ANION TRANSPORTING POLYPEPTIDES IN THE TRANSPORT OF TROGLITAZONE SULFATE: IMPLICATIONS FOR UNDERSTANDING TROGLITAZONE HEPATOTOXICITY
Takashi Nozawa, Shigeki Sugiura, Miki Nakajima, Akihiko Goto, Tsuyoshi Yokoi, Jun-Ichi Nezu, Akira Tsuji and Ikumi Tamai

Drug Metabolism and Disposition March 2004, 32 (3) 291-294; DOI: https://doi.org/10.1124/dmd.32.3.291

Articles

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IMPACT OF INCUBATION CONDITIONS ON BUFURALOL HUMAN CLEARANCE PREDICTIONS: ENZYME LABILITY AND NONSPECIFIC BINDING
Robert S. Foti and Michael B. Fisher

Drug Metabolism and Disposition March 2004, 32 (3) 295-304; DOI: https://doi.org/10.1124/dmd.32.3.295
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STEREO- AND REGIOSELECTIVITY ACCOUNT FOR THE DIVERSITY OF DEHYDROEPIANDROSTERONE (DHEA) METABOLITES PRODUCED BY LIVER MICROSOMAL CYTOCHROMES P450
Kristy K. Michael Miller, Jian Cai, Sharon L. Ripp, William M. Pierce, Thomas H. Rushmore and Russell A. Prough

Drug Metabolism and Disposition March 2004, 32 (3) 305-313; DOI: https://doi.org/10.1124/dmd.32.3.305
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IDENTIFICATION OF HUMAN UDP-GLUCURONOSYLTRANSFERASE ENZYME(S) RESPONSIBLE FOR THE GLUCURONIDATION OF EZETIMIBE (ZETIA)
Anima Ghosal, Neil Hapangama, Yuan Yuan, Joana Achanfuo-Yeboah, Robert Iannucci, Swapan Chowdhury, Kevin Alton, James E. Patrick and Shmuel Zbaida

Drug Metabolism and Disposition March 2004, 32 (3) 314-320; DOI: https://doi.org/10.1124/dmd.32.3.314
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CYTOTOXICITY OF THE NOVEL GLUTATHIONE-ACTIVATED THIOPURINE PRODRUGS CIS-AVTP [CIS-6-(2-ACETYLVINYLTHIO)PURINE] AND TRANS-AVTG [TRANS-6-(2-ACETYLVINYLTHIO)GUANINE] RESULTS FROM THE NATIONAL CANCER INSTITUTE'S ANTICANCER DRUG SCREEN
Sjofn Gunnarsdottir and Adnan A. Elfarra

Drug Metabolism and Disposition March 2004, 32 (3) 321-327; DOI: https://doi.org/10.1124/dmd.32.3.321
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AN ANALYSIS OF THE REGIOSELECTIVITY OF AROMATIC HYDROXYLATION AND N-OXYGENATION BY CYTOCHROME P450 ENZYMES
Tamara S. Dowers, Dan A. Rock, Denise A. Rock, Brandon N. S. Perkins and Jeffery P. Jones

Drug Metabolism and Disposition March 2004, 32 (3) 328-332; DOI: https://doi.org/10.1124/dmd.32.3.328
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IN VITRO SULFOXIDATION OF THIOETHER COMPOUNDS BY HUMAN CYTOCHROME P450 AND FLAVIN-CONTAINING MONOOXYGENASE ISOFORMS WITH PARTICULAR REFERENCE TO THE CYP2C SUBFAMILY
Khawja A. Usmani, Edward D. Karoly, Ernest Hodgson and Randy L. Rose

Drug Metabolism and Disposition March 2004, 32 (3) 333-339; DOI: https://doi.org/10.1124/dmd.32.3.333
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HUMAN PXR VARIANTS AND THEIR DIFFERENTIAL EFFECTS ON THE REGULATION OF HUMAN UDP-GLUCURONOSYLTRANSFERASE GENE EXPRESSION
Dione Gardner-Stephen, Jean-Marie Heydel, Amit Goyal, Yuan Lu, Wen Xie, Tim Lindblom, Peter Mackenzie and Anna Radominska-Pandya

Drug Metabolism and Disposition March 2004, 32 (3) 340-347; DOI: https://doi.org/10.1124/dmd.32.3.340
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REGULATION OF CYP2B6 IN PRIMARY HUMAN HEPATOCYTES BY PROTOTYPICAL INDUCERS
Stephanie R. Faucette, Hongbing Wang, Geraldine A. Hamilton, Summer L. Jolley, Darryl Gilbert, Celeste Lindley, Bingfang Yan, Masahiko Negishi and Edward L. LeCluyse

Drug Metabolism and Disposition March 2004, 32 (3) 348-358; DOI: https://doi.org/10.1124/dmd.32.3.348

Accelerated Communication

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KUPFFER CELL-MEDIATED IL-2 SUPPRESSION OF CYP3A ACTIVITY IN HUMAN HEPATOCYTES
Jeffrey A. Sunman, Roy L. Hawke, Edward L. LeCluyse and Angela D. M. Kashuba

Drug Metabolism and Disposition March 2004, 32 (3) 359-363; DOI: https://doi.org/10.1124/dmd.32.3.359

Letter to the Editor

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IS 17α-ETHINYL ESTRADIOL AN INHIBITOR OF CYTOCHROME P450 2C19?
A. David Rodrigues and Ping Lu

Drug Metabolism and Disposition March 2004, 32 (3) 364-365; DOI: https://doi.org/10.1124/dmd.32.3.364

Erratum

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CORRECTION TO “STUDIES ON THE METABOLISM OF THE NOVEL, SELECTIVE CYCLOOXYGENASE-2 INHIBITOR INDOMETHACIN PHENETHYLAMIDE IN RAT, MOUSE, AND HUMAN LIVER MICROSOMES: IDENTIFICATION OF ACTIVE METABOLITES”
Drug Metabolism and Disposition March 2004, 32 (3) 366; DOI: https://doi.org/10.1124/dmd.32.3.366

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