Drug Metabolism and Disposition: 32 (4)

April 01, 2004; Volume 32,Issue 4

Symposium Article

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TRANSCRIPTIONAL SUPPRESSION OF CYTOCHROME P450 GENES BY ENDOGENOUS AND EXOGENOUS CHEMICALS
David S. Riddick, Chunja Lee, Anahita Bhathena, Yoav E. Timsit, Po-Yung Cheng, Edward T. Morgan, Russell A. Prough, Sharon L. Ripp, Kristy K. Michael Miller, Asmeen Jahan and John Y. L. Chiang

Drug Metabolism and Disposition April 2004, 32 (4) 367-375; DOI: https://doi.org/10.1124/dmd.32.4.367

Short Communications

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CLONING CYP2D21 AND CYP3A22 CDNAS FROM LIVER OF MINIATURE PIGS
Tsutomu Sakuma, Tsukasa Shimojima, Kiyoshi Miwa and Tetsuya Kamataki

Drug Metabolism and Disposition April 2004, 32 (4) 376-378; DOI: https://doi.org/10.1124/dmd.32.4.376
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IDENTIFICATION OF HUMAN CYTOCHROME P450 2D6 AS MAJOR ENZYME INVOLVED IN THE O-DEMETHYLATION OF THE DESIGNER DRUG P-METHOXYMETHAMPHETAMINE
Roland F. Staack, Denis S. Theobald, Liane D. Paul, Dietmar Springer, Thomas Kraemer and Hans H. Maurer

Drug Metabolism and Disposition April 2004, 32 (4) 379-381; DOI: https://doi.org/10.1124/dmd.32.4.379
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A PROTEOMIC APPROACH TO THE IDENTIFICATION OF CYTOCHROME P450 ISOFORMS IN MALE AND FEMALE RAT LIVER BY NANOSCALE LIQUID CHROMATOGRAPHY-ELECTROSPRAY IONIZATION-TANDEM MASS SPECTROMETRY
S. Nisar, C. S. Lane, A. F. Wilderspin, K. J. Welham, W. J. Griffiths and L. H. Patterson

Drug Metabolism and Disposition April 2004, 32 (4) 382-386; DOI: https://doi.org/10.1124/dmd.32.4.382

Articles

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NEW METABOLIC PATHWAYS FOR FLAVANONES CATALYZED BY RAT LIVER MICROSOMES
Dejan Nikolic and Richard B. van Breemen

Drug Metabolism and Disposition April 2004, 32 (4) 387-397; DOI: https://doi.org/10.1124/dmd.32.4.387
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COMPARISON OF PREDICTION METHODS FOR IN VIVO CLEARANCE OF (S,S)-3-[3-(METHYLSULFONYL)PHENYL]-1-PROPYLPIPERIDINE HYDROCHLORIDE, A DOPAMINE D2 RECEPTOR ANTAGONIST, IN HUMANS
Shinji Yamazaki, Lisa N. Toth, Meredith L. Black and J. Neil Duncan

Drug Metabolism and Disposition April 2004, 32 (4) 398-404; DOI: https://doi.org/10.1124/dmd.32.4.398
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HEPATOBILIARY EXCRETION OF BERBERINE
Pi-Lo Tsai and Tung-Hu Tsai

Drug Metabolism and Disposition April 2004, 32 (4) 405-412; DOI: https://doi.org/10.1124/dmd.32.4.405
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HUMAN UDP-GLUCURONOSYLTRANSFERASES: ISOFORM SELECTIVITY AND KINETICS OF 4-METHYLUMBELLIFERONE AND 1-NAPHTHOL GLUCURONIDATION, EFFECTS OF ORGANIC SOLVENTS, AND INHIBITION BY DICLOFENAC AND PROBENECID
Verawan Uchaipichat, Peter I. Mackenzie, Xiao-Hui Guo, Dione Gardner-Stephen, Aleksandra Galetin, J. Brian Houston and John O. Miners

Drug Metabolism and Disposition April 2004, 32 (4) 413-423; DOI: https://doi.org/10.1124/dmd.32.4.413
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EXPRESSION STUDIES AND FUNCTIONAL CHARACTERIZATION OF RENAL HUMAN ORGANIC ANION TRANSPORTER 1 ISOFORMS
Andrew Bahn, Christian Ebbinghaus, Diana Ebbinghaus, Evgeni G. Ponimaskin, Laszlo Fuzesï, Gerhard Burckhardt and Yohannes Hagos

Drug Metabolism and Disposition April 2004, 32 (4) 424-430; DOI: https://doi.org/10.1124/dmd.32.4.424
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ASSESSMENT OF ARGININE 97 AND LYSINE 72 AS DETERMINANTS OF SUBSTRATE SPECIFICITY IN CYTOCHROME P450 2C9 (CYP2C9)
Carwyn Davies, Katey Witham, Justin R. Scott, Andrew Pearson, James J. DeVoss, Sandra E. Graham and Elizabeth M. J. Gillam

Drug Metabolism and Disposition April 2004, 32 (4) 431-436; DOI: https://doi.org/10.1124/dmd.32.4.431
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ENDOTOXIN-MEDIATED DISTURBANCE OF HEPATIC CYTOCHROME P450 FUNCTION AND DEVELOPMENT OF ENDOTOXIN TOLERANCE IN THE RAT MODEL OF DEXTRAN SULFATE SODIUM-INDUCED EXPERIMENTAL COLITIS
Yasuhiro Masubuchi and Toshiharu Horie

Drug Metabolism and Disposition April 2004, 32 (4) 437-441; DOI: https://doi.org/10.1124/dmd.32.4.437
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INCORPORATION OF AN OXYGEN FROM WATER INTO TROGLITAZONE QUINONE BY CYTOCHROME P450 AND MYELOPEROXIDASE
Kan He, Rasmy E. Talaat and Thomas F. Woolf

Drug Metabolism and Disposition April 2004, 32 (4) 442-446; DOI: https://doi.org/10.1124/dmd.32.4.442
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QUANTITATIVE CONTRIBUTION OF CYP2D6 AND CYP3A TO OXYCODONE METABOLISM IN HUMAN LIVER AND INTESTINAL MICROSOMES
Bojan Lalovic, Brian Phillips, Linda L. Risler, William Howald and Danny D. Shen

Drug Metabolism and Disposition April 2004, 32 (4) 447-454; DOI: https://doi.org/10.1124/dmd.32.4.447
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AMINO ACID RESIDUE ILE211 IS ESSENTIAL FOR THE ENZYMATIC ACTIVITY OF HUMAN UDP-GLUCURONOSYLTRANSFERASE 1A10 (UGT1A10)
Isabelle Martineau, André Tchernof and Alain Bélanger

Drug Metabolism and Disposition April 2004, 32 (4) 455-459; DOI: https://doi.org/10.1124/dmd.32.4.455
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THE EFFECT OF CIMETIDINE ON DEXTROMETHORPHAN O-DEMETHYLASE ACTIVITY OF HUMAN LIVER MICROSOMES AND RECOMBINANT CYP2D6
Maria Madeira, Marc Levine, Thomas K. H. Chang, Ahmad Mirfazaelian and Gail D. Bellward

Drug Metabolism and Disposition April 2004, 32 (4) 460-467; DOI: https://doi.org/10.1124/dmd.32.4.460
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KEY STRUCTURAL FEATURES OF LIGANDS FOR ACTIVATION OF HUMAN PREGNANE X RECEPTOR
Kaoru Kobayashi, Saeko Yamagami, Tomoaki Higuchi, Masakiyo Hosokawa and Kan Chiba

Drug Metabolism and Disposition April 2004, 32 (4) 468-472; DOI: https://doi.org/10.1124/dmd.32.4.468

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