Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • Log out
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • Log out
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
OtherSymposium Article

TRANSCRIPTIONAL SUPPRESSION OF CYTOCHROME P450 GENES BY ENDOGENOUS AND EXOGENOUS CHEMICALS

David S. Riddick, Chunja Lee, Anahita Bhathena, Yoav E. Timsit, Po-Yung Cheng, Edward T. Morgan, Russell A. Prough, Sharon L. Ripp, Kristy K. Michael Miller, Asmeen Jahan and John Y. L. Chiang
Drug Metabolism and Disposition April 2004, 32 (4) 367-375; DOI: https://doi.org/10.1124/dmd.32.4.367
David S. Riddick
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chunja Lee
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anahita Bhathena
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yoav E. Timsit
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Po-Yung Cheng
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Edward T. Morgan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Russell A. Prough
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sharon L. Ripp
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kristy K. Michael Miller
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Asmeen Jahan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John Y. L. Chiang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

This article is an invited report of a symposium sponsored by the Division for Drug Metabolism of the American Society for Pharmacology and Experimental Therapeutics held at Experimental Biology 2003 in San Diego, California, April 11-15, 2003. Several members of the cytochrome P450 (P450) superfamily are induced after exposure to a variety of chemical signals, and we have gained considerable mechanistic insight into these processes over the past four decades. In addition, the expression of many P450s is suppressed in response to various endogenous and exogenous chemicals; however, relatively little is known about the molecular mechanisms involved. The goal of this symposium was to critically examine our current understanding of molecular mechanisms involved in transcriptional suppression of CYP genes by endogenous and exogenous chemicals. Specific examples were drawn from the following chemical categories: polycyclic and halogenated aromatic hydrocarbon environmental toxicants, inflammatory mediators, the endogenous sterol dehydroepiandrosterone and peroxisome proliferators, and bile acids. Multiple molecular mechanisms are involved in transcriptional suppression, and these processes often involve rather complex cascades of transcription factors and other regulatory proteins. Mechanistic studies of CYP gene suppression can enhance our understanding of how organisms respond to xenobiotics as well as to perturbations in endogenous chemicals involved in maintaining homeostasis.

Footnotes

  • ↵1 Abbreviations used are: P450, cytochrome P450; ADIOL, androst-5-ene-3,17-diol; ADIONE, androst-5-ene-3,17-dione; AHR, aromatic hydrocarbon receptor; BARE, bile acid response element; bp, base pair(s); CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; DHEA, dehydroepiandrosterone; DHEA-S, dehydroepiandrosterone sulfate; DRE, dioxin-responsive element; FTF, α-fetoprotein transcription factor; FXR, farnesoid X receptor; GH, growth hormone; HCA, hyocholic acid; HDCA, hyodeoxycholic acid; HNF, hepatocyte nuclear factor; IκB, inhibitory protein of nuclear factor-κB; IL, interleukin; JNK, cJun N-terminal kinase; LCA, lithocholic acid; LIP, liver-enriched transcriptional inhibitory protein; LPS, bacterial lipopolysaccharide; LXR, liver X receptor; MAPK, mitogen-activated protein kinase; MC, 3-methylcholanthrene; NF-κB, nuclear factor-κB; PAH, polycyclic aromatic hydrocarbon; PCN, pregnenolone 16α-carbonitrile; PPAR, peroxisome proliferator-activated receptor; PXR, pregnane X receptor; SHP, small heterodimer partner; STAT, signal transducer and activator of transcription; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; TF, transcription factor; VDR, vitamin D receptor.

  • Supported in part by Canadian Institutes of Health Research Grant MOP-42399 (D.S.R.), United States Public Health Service Grant DK54774 (R.A.P.), National Research Service Award Fellowship F32 ES05927 (S.L.R.), American Heart Association Predoctoral Fellowship 0110109 (K.K.M.M.), National Institutes of Health Grants DK58379 and DK44442 (J.Y.L.C), and American Heart Association Ohio Valley Affiliates Predoctoral Fellowship and an American Liver Foundation Summer Student Fellowship (A.J.).

    • Received October 7, 2003.
    • Accepted December 19, 2003.
  • The American Society for Pharmacology and Experimental Therapeutics
View Full Text

 

DMD articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 32 (4)
Drug Metabolism and Disposition
Vol. 32, Issue 4
1 Apr 2004
  • Table of Contents
  • About the Cover
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
TRANSCRIPTIONAL SUPPRESSION OF CYTOCHROME P450 GENES BY ENDOGENOUS AND EXOGENOUS CHEMICALS
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
OtherSymposium Article

TRANSCRIPTIONAL SUPPRESSION OF CYTOCHROME P450 GENES BY ENDOGENOUS AND EXOGENOUS CHEMICALS

David S. Riddick, Chunja Lee, Anahita Bhathena, Yoav E. Timsit, Po-Yung Cheng, Edward T. Morgan, Russell A. Prough, Sharon L. Ripp, Kristy K. Michael Miller, Asmeen Jahan and John Y. L. Chiang
Drug Metabolism and Disposition April 1, 2004, 32 (4) 367-375; DOI: https://doi.org/10.1124/dmd.32.4.367

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
OtherSymposium Article

TRANSCRIPTIONAL SUPPRESSION OF CYTOCHROME P450 GENES BY ENDOGENOUS AND EXOGENOUS CHEMICALS

David S. Riddick, Chunja Lee, Anahita Bhathena, Yoav E. Timsit, Po-Yung Cheng, Edward T. Morgan, Russell A. Prough, Sharon L. Ripp, Kristy K. Michael Miller, Asmeen Jahan and John Y. L. Chiang
Drug Metabolism and Disposition April 1, 2004, 32 (4) 367-375; DOI: https://doi.org/10.1124/dmd.32.4.367
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Positive and Negative Transcriptional Regulation of Cytochromes P450 by Polycyclic Aromatic Hydrocarbons (D.S.R., C.L., A.B., Y.E.T.)
    • Down-Regulation of Cytochromes P450 by Inflammatory Mediators (P.-Y.C., E.T.M.).
    • Dehydroepiandrosterone Is Metabolized by and Modulates Expression of Multiple Cytochromes P450 (R.A.P., S.L.R., K.K.M.M.)
    • Bile Acid and Nuclear Receptor Regulation of Cytochrome P450 Gene Transcription (A.J., J.Y.L.C.)
    • Concluding Remarks
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Targeting Drug-Metabolizing Enzymes for Effective Chemoprevention and Chemotherapy
  • GLUCURONIDATION AND THE UDP-GLUCURONOSYLTRANSFERASES IN HEALTH AND DISEASE
Show more SYMPOSIUM ARTICLES

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics