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Drug Metabolism & Disposition

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Table of Contents

May 01, 2004; Volume 32,Issue 5

Short Communication

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    CYTOCHROME P450 2C8 (CYP2C8)-MEDIATED HYDROXYLATION OF AN ENDOTHELIN ETA RECEPTOR ANTAGONIST IN HUMAN LIVER MICROSOMES
    Bennett Ma, Raju Subramanian, Michael L. Schrag, A. David Rodrigues and Cuyue Tang
    Drug Metabolism and Disposition May 2004, 32 (5) 473-478; DOI: https://doi.org/10.1124/dmd.32.5.473

Articles

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    RENAL TRANSPORT OF ORGANIC COMPOUNDS MEDIATED BY MOUSE ORGANIC ANION TRANSPORTER 3 (MOAT3): FURTHER SUBSTRATE SPECIFICITY OF MOAT3
    Yasuna Kobayashi, Naomi Ohshiro, Ayumi Tsuchiya, Noriko Kohyama, Masayuki Ohbayashi and Toshinori Yamamoto
    Drug Metabolism and Disposition May 2004, 32 (5) 479-483; DOI: https://doi.org/10.1124/dmd.32.5.479
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    THE IMPACT OF CYP2C9 GENETICS AND ORAL CONTRACEPTIVES ON CYTOCHROME P450 2C9 PHENOTYPE
    Mia Sandberg, Inger Johansson, Magnus Christensen, Anders Rane and Erik Eliasson
    Drug Metabolism and Disposition May 2004, 32 (5) 484-489; DOI: https://doi.org/10.1124/dmd.32.5.484
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    IN VITRO METABOLISM OF THE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR, WORTMANNIN, BY CARBONYL REDUCTASE
    Julianne L. Holleran, Julien Fourcade, Merrill J. Egorin, Julie L. Eiseman, Robert A. Parise, Steven M. Musser, Kevin D. White, Joseph M. Covey, Gerald L. Forrest and Su-Shu Pan
    Drug Metabolism and Disposition May 2004, 32 (5) 490-496; DOI: https://doi.org/10.1124/dmd.32.5.490
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    STRONG INHIBITORY EFFECTS OF COMMON TEA CATECHINS AND BIOFLAVONOIDS ON THE O-METHYLATION OF CATECHOL ESTROGENS CATALYZED BY HUMAN LIVER CYTOSOLIC CATECHOL-O-METHYLTRANSFERASE
    Mime Nagai, Allan H. Conney and Bao Ting Zhu
    Drug Metabolism and Disposition May 2004, 32 (5) 497-504; DOI: https://doi.org/10.1124/dmd.32.5.497
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    HYDROLYSIS OF IRINOTECAN AND ITS OXIDATIVE METABOLITES, 7-ETHYL-10-[4-N-(5-AMINOPENTANOIC ACID)-1-PIPERIDINO] CARBONYLOXYCAMPTOTHECIN AND 7-ETHYL-10-[4-(1-PIPERIDINO)-1-AMINO]-CARBONYLOXYCAMPTOTHECIN, BY HUMAN CARBOXYLESTERASES CES1A1, CES2, AND A NEWLY EXPRESSED CARBOXYLESTERASE ISOENZYME, CES3
    Sonal P. Sanghani, Sara K. Quinney, Tyler B. Fredenburg, Wilhelmina I. Davis, Daryl J. Murry and William F. Bosron
    Drug Metabolism and Disposition May 2004, 32 (5) 505-511; DOI: https://doi.org/10.1124/dmd.32.5.505
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    INDUCTION AND INHIBITION OF CYTOCHROMES P450 BY THE ST. JOHN'S WORT CONSTITUENT HYPERFORIN IN HUMAN HEPATOCYTE CULTURES
    Bernard J. Komoroski, Shimin Zhang, Hongbo Cai, J. Matthew Hutzler, Reginald Frye, Timothy S. Tracy, Stephen C. Strom, Thomas Lehmann, Catharina Y. W. Ang, Yan Yan Cui and Raman Venkataramanan
    Drug Metabolism and Disposition May 2004, 32 (5) 512-518; DOI: https://doi.org/10.1124/dmd.32.5.512
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    INFLUX AND EFFLUX TRANSPORT OF H1-ANTAGONIST EPINASTINE ACROSS THE BLOOD-BRAIN BARRIER
    Naoki Ishiguro, Takashi Nozawa, Akiko Tsujihata, Asami Saito, Wataru Kishimoto, Kazutoshi Yokoyama, Takafumi Yotsumoto, Kenji Sakai, Takashi Igarashi and Ikumi Tamai
    Drug Metabolism and Disposition May 2004, 32 (5) 519-524; DOI: https://doi.org/10.1124/dmd.32.5.519
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    ROLE OF Sp1, C/EBPα, HNF3, AND PXR IN THE BASAL- AND XENOBIOTIC-MEDIATED REGULATION OF THE CYP3A4 GENE
    Vincent Bombail, Kevin Taylor, G. Gordon Gibson and Nick Plant
    Drug Metabolism and Disposition May 2004, 32 (5) 525-535; DOI: https://doi.org/10.1124/dmd.32.5.525
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    COMPARATIVE HEPATIC AND EXTRAHEPATIC ENANTIOSELECTIVE SULFOXIDATION OF ALBENDAZOLE AND FENBENDAZOLE IN SHEEP AND CATTLE
    G. Virkel, A. Lifschitz, J. Sallovitz, A. Pis and C. Lanusse
    Drug Metabolism and Disposition May 2004, 32 (5) 536-544; DOI: https://doi.org/10.1124/dmd.32.5.536
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    AMIDE N-GLUCURONIDATION OF MAXIPOST CATALYZED BY UDP-GLUCURONOSYLTRANSFERASE 2B7 IN HUMANS
    Donglu Zhang, Weiping Zhao, Vikram A. Roongta, James G. Mitroka, Lewis J. Klunk and Mingshe Zhu
    Drug Metabolism and Disposition May 2004, 32 (5) 545-551; DOI: https://doi.org/10.1124/dmd.32.5.545
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    COMPARISON OF FRESH AND CRYOPRESERVED RAT HEPATOCYTE SUSPENSIONS FOR THE PREDICTION OF IN VITRO INTRINSIC CLEARANCE
    Sarah J. Griffin and J. Brian Houston
    Drug Metabolism and Disposition May 2004, 32 (5) 552-558; DOI: https://doi.org/10.1124/dmd.32.5.552
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    INFLUENCE OF PHENYLALANINES 77 AND 138 ON THE STEREOSPECIFICITY OF ARYL SULFOTRANSFERASE IV
    Jonathan J. Sheng, Atmaja Saxena and Michael W. Duffel
    Drug Metabolism and Disposition May 2004, 32 (5) 559-565; DOI: https://doi.org/10.1124/dmd.32.5.559
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    PHARMACOKINETICS AND METABOLISM OF LUMIRACOXIB IN HEALTHY MALE SUBJECTS
    James B. Mangold, Helen Gu, Lolita C. Rodriguez, Johanne Bonner, Janet Dickson and Christiane Rordorf
    Drug Metabolism and Disposition May 2004, 32 (5) 566-571; DOI: https://doi.org/10.1124/dmd.32.5.566
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    QUANTITATIVE PREDICTION OF THE IN VIVO INHIBITION OF DIAZEPAM METABOLISM BY OMEPRAZOLE USING RAT LIVER MICROSOMES AND HEPATOCYTES
    Hannah M. Jones, David Hallifax and J. Brian Houston
    Drug Metabolism and Disposition May 2004, 32 (5) 572-580; DOI: https://doi.org/10.1124/dmd.32.5.572
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Drug Metabolism and Disposition: 32 (5)
Drug Metabolism and Disposition
Vol. 32, Issue 5
1 May 2004
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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