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HYDROLYSIS OF IRINOTECAN AND ITS OXIDATIVE METABOLITES, 7-ETHYL-10-[4-N-(5-AMINOPENTANOIC ACID)-1-PIPERIDINO] CARBONYLOXYCAMPTOTHECIN AND 7-ETHYL-10-[4-(1-PIPERIDINO)-1-AMINO]-CARBONYLOXYCAMPTOTHECIN, BY HUMAN CARBOXYLESTERASES CES1A1, CES2, AND A NEWLY EXPRESSED CARBOXYLESTERASE ISOENZYME, CES3

Sonal P. Sanghani, Sara K. Quinney, Tyler B. Fredenburg, Wilhelmina I. Davis, Daryl J. Murry and William F. Bosron
Drug Metabolism and Disposition May 2004, 32 (5) 505-511; DOI: https://doi.org/10.1124/dmd.32.5.505

Article Information

vol. 32 no. 5 505-511
DOI 
https://doi.org/10.1124/dmd.32.5.505
PubMed 
15100172
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 24, 2003
  • Accepted February 4, 2004
  • Published online April 20, 2004.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sonal P. Sanghani,
  2. Sara K. Quinney,
  3. Tyler B. Fredenburg,
  4. Wilhelmina I. Davis,
  5. Daryl J. Murry and
  6. William F. Bosron
  1. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana (S.P.S., T.B.F., W.I.D., W.F.B.); Purdue University, School of Pharmacy and Pharmacal Sciences, Department of Pharmacy Practice, Indianapolis, Indiana (S.K.Q.); and University of Iowa, College of Pharmacy, Iowa City, Iowa (D.J.M.)
  1. Address correspondence to:
    William F. Bosron, Biotechnology Research and Training Center, Indiana University School of Medicine, 1345 W. 16th Street, Room L3-304, Indianapolis IN 46202. E-mail: wbosron{at}iupui.edu
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Research ArticleArticle

HYDROLYSIS OF IRINOTECAN AND ITS OXIDATIVE METABOLITES, 7-ETHYL-10-[4-N-(5-AMINOPENTANOIC ACID)-1-PIPERIDINO] CARBONYLOXYCAMPTOTHECIN AND 7-ETHYL-10-[4-(1-PIPERIDINO)-1-AMINO]-CARBONYLOXYCAMPTOTHECIN, BY HUMAN CARBOXYLESTERASES CES1A1, CES2, AND A NEWLY EXPRESSED CARBOXYLESTERASE ISOENZYME, CES3

Sonal P. Sanghani, Sara K. Quinney, Tyler B. Fredenburg, Wilhelmina I. Davis, Daryl J. Murry and William F. Bosron
Drug Metabolism and Disposition May 1, 2004, 32 (5) 505-511; DOI: https://doi.org/10.1124/dmd.32.5.505
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