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HYDROLYSIS OF IRINOTECAN AND ITS OXIDATIVE METABOLITES, 7-ETHYL-10-[4-N-(5-AMINOPENTANOIC ACID)-1-PIPERIDINO] CARBONYLOXYCAMPTOTHECIN AND 7-ETHYL-10-[4-(1-PIPERIDINO)-1-AMINO]-CARBONYLOXYCAMPTOTHECIN, BY HUMAN CARBOXYLESTERASES CES1A1, CES2, AND A NEWLY EXPRESSED CARBOXYLESTERASE ISOENZYME, CES3

Sonal P. Sanghani, Sara K. Quinney, Tyler B. Fredenburg, Wilhelmina I. Davis, Daryl J. Murry and William F. Bosron
Drug Metabolism and Disposition May 2004, 32 (5) 505-511; DOI: https://doi.org/10.1124/dmd.32.5.505
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Research ArticleArticle

HYDROLYSIS OF IRINOTECAN AND ITS OXIDATIVE METABOLITES, 7-ETHYL-10-[4-N-(5-AMINOPENTANOIC ACID)-1-PIPERIDINO] CARBONYLOXYCAMPTOTHECIN AND 7-ETHYL-10-[4-(1-PIPERIDINO)-1-AMINO]-CARBONYLOXYCAMPTOTHECIN, BY HUMAN CARBOXYLESTERASES CES1A1, CES2, AND A NEWLY EXPRESSED CARBOXYLESTERASE ISOENZYME, CES3

Sonal P. Sanghani, Sara K. Quinney, Tyler B. Fredenburg, Wilhelmina I. Davis, Daryl J. Murry and William F. Bosron
Drug Metabolism and Disposition May 1, 2004, 32 (5) 505-511; DOI: https://doi.org/10.1124/dmd.32.5.505
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