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Research ArticleArticle

INDUCTION AND INHIBITION OF CYTOCHROMES P450 BY THE ST. JOHN'S WORT CONSTITUENT HYPERFORIN IN HUMAN HEPATOCYTE CULTURES

Bernard J. Komoroski, Shimin Zhang, Hongbo Cai, J. Matthew Hutzler, Reginald Frye, Timothy S. Tracy, Stephen C. Strom, Thomas Lehmann, Catharina Y. W. Ang, Yan Yan Cui and Raman Venkataramanan
Drug Metabolism and Disposition May 2004, 32 (5) 512-518; DOI: https://doi.org/10.1124/dmd.32.5.512

Article Information

vol. 32 no. 5 512-518
DOI 
https://doi.org/10.1124/dmd.32.5.512
PubMed 
15100173
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 7, 2003
  • Accepted February 5, 2004
  • Published online April 20, 2004.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Bernard J. Komoroski,
  2. Shimin Zhang,
  3. Hongbo Cai,
  4. J. Matthew Hutzler1,
  5. Reginald Frye2,
  6. Timothy S. Tracy3,
  7. Stephen C. Strom,
  8. Thomas Lehmann,
  9. Catharina Y. W. Ang,
  10. Yan Yan Cui and
  11. Raman Venkataramanan
  1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh (B.J.K., S.Z., R.F., R.V.), and Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania (H.C., S.C.S., T.L., R.V.); West Virginia University, School of Pharmacy, Morgantown, West Virginia (M.H., T.S.T.); and Division of Chemistry, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas (C.Y.W.A., Y.Y.C.)
  1. Address correspondence to:
    Dr. Raman Venkataramanan, 718 Salk Hall, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261. E-mail: rv{at}pitt.edu
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Research ArticleArticle

INDUCTION AND INHIBITION OF CYTOCHROMES P450 BY THE ST. JOHN'S WORT CONSTITUENT HYPERFORIN IN HUMAN HEPATOCYTE CULTURES

Bernard J. Komoroski, Shimin Zhang, Hongbo Cai, J. Matthew Hutzler, Reginald Frye, Timothy S. Tracy, Stephen C. Strom, Thomas Lehmann, Catharina Y. W. Ang, Yan Yan Cui and Raman Venkataramanan
Drug Metabolism and Disposition May 1, 2004, 32 (5) 512-518; DOI: https://doi.org/10.1124/dmd.32.5.512
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