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Drug Metabolism & Disposition

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Table of Contents

July 01, 2004; Volume 32,Issue 7

Short Communications

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    ROLE OF MOUSE CYP2E1 IN THE O-HYDROXYLATION OF P-NITROPHENOL: COMPARISON OF ACTIVITIES IN HEPATIC MICROSOMES FROM CYP2E1(-/-) AND WILD-TYPE MICE
    Kristina K. Wolf, Sheryl G. Wood, Jenna L. Bement, Peter R. Sinclair, Steven A. Wrighton, Elizabeth Jeffery, Frank J. Gonzalez and Jacqueline F. Sinclair
    Drug Metabolism and Disposition July 2004, 32 (7) 681-684; DOI: https://doi.org/10.1124/dmd.32.7.681
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    C-JUN N-TERMINAL KINASE MODULATES 1,25-DIHYDROXYVITAMIN D3-INDUCED CYTOCHROME P450 3A4 GENE EXPRESSION
    Yoko Yasunami, Hirokazu Hara, Tatsunori Iwamura, Tadashi Kataoka and Tetsuo Adachi
    Drug Metabolism and Disposition July 2004, 32 (7) 685-688; DOI: https://doi.org/10.1124/dmd.32.7.685

Articles

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    METABOLISM AND EXCRETION OF CAPRAVIRINE, A NEW NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR, ALONE AND IN COMBINATION WITH RITONAVIR IN HEALTHY VOLUNTEERS
    Hai-Zhi Bu, William F. Pool, Ellen Y. Wu, Susan R. Raber, Michael A. Amantea and Bhasker V. Shetty
    Drug Metabolism and Disposition July 2004, 32 (7) 689-698; DOI: https://doi.org/10.1124/dmd.32.7.689
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    FLUORESCENCE-BASED ASSAYS FOR SCREENING NINE CYTOCHROME P450 (P450) ACTIVITIES IN INTACT CELLS EXPRESSING INDIVIDUAL HUMAN P450 ENZYMES
    M. Teresa Donato, Nuria Jiménez, José V. Castell and M. José Gómez-Lechón
    Drug Metabolism and Disposition July 2004, 32 (7) 699-706; DOI: https://doi.org/10.1124/dmd.32.7.699
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    INVOLVEMENT OF INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR α IN CYP3A11 AND 2C29 DOWN-REGULATION BY BACILLUS CALMETTE-GUÉRIN AND LIPOPOLYSACCHARIDE IN MOUSE LIVER
    Takashi Ashino, Takiko Oguro, Seiji Shioda, Reiko Horai, Masahide Asano, Kenji Sekikawa, Yoichiro Iwakura, Satoshi Numazawa and Takemi Yoshida
    Drug Metabolism and Disposition July 2004, 32 (7) 707-714; DOI: https://doi.org/10.1124/dmd.32.7.707
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    AN EVALUATION OF THE IN VITRO METABOLISM DATA FOR PREDICTING THE CLEARANCE AND DRUG-DRUG INTERACTION POTENTIAL OF CYP2C9 SUBSTRATES
    Tommy B. Andersson, Eva Bredberg, Hans Ericsson and Helena Sjöberg
    Drug Metabolism and Disposition July 2004, 32 (7) 715-721; DOI: https://doi.org/10.1124/dmd.32.7.715
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    THE SYSTEMIC EXPOSURE OF AN N-METHYL-d-ASPARTATE RECEPTOR ANTAGONIST IS LIMITED IN MICE BY THE P-GLYCOPROTEIN AND BREAST CANCER RESISTANCE PROTEIN EFFLUX TRANSPORTERS
    Joseph W. Polli, Todd M. Baughman, Joan E. Humphreys, Kelly H. Jordan, Angela L. Mote, Lindsey O. Webster, Robert J. Barnaby, Giovanni Vitulli, Luigina Bertolotti, Kevin D. Read and Cosette J. Serabjit-Singh
    Drug Metabolism and Disposition July 2004, 32 (7) 722-726; DOI: https://doi.org/10.1124/dmd.32.7.722
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    THE EFFECT OF ISONIAZID ON CYP2E1- AND CYP4A-MEDIATED HYDROXYLATION OF ARACHIDONIC ACID IN THE RAT LIVER AND KIDNEY
    Samuel M. Poloyac, Michael A. Tortorici, Danielle I. Przychodzin, Robert B. Reynolds, Wen Xie, Reginald F. Frye and Michael A. Zemaitis
    Drug Metabolism and Disposition July 2004, 32 (7) 727-733; DOI: https://doi.org/10.1124/dmd.32.7.727
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    LIPOPOLYSACCHARIDE-MEDIATED REGULATION OF HEPATIC TRANSPORTER mRNA LEVELS IN RATS
    Nathan J. Cherrington, Angela L. Slitt, Ning Li and Curtis D. Klaassen
    Drug Metabolism and Disposition July 2004, 32 (7) 734-741; DOI: https://doi.org/10.1124/dmd.32.7.734
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    GLUCURONIDATION OF THE OXIDATIVE CYTOCHROME P450-MEDIATED PHENOLIC METABOLITES OF THE ENDOCRINE DISRUPTOR PESTICIDE: METHOXYCHLOR BY HUMAN HEPATIC UDP-GLUCURONOSYL TRANSFERASES
    Eszter Hazai, Peter V. Gagne and David Kupfer
    Drug Metabolism and Disposition July 2004, 32 (7) 742-751; DOI: https://doi.org/10.1124/dmd.32.7.742
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    MAGNESIUM LITHOSPERMATE B IS EXCRETED RAPIDLY INTO RAT BILE MOSTLY AS METHYLATED METABOLITES, WHICH ARE POTENT ANTIOXIDANTS
    Ying Zhang, Teruaki Akao, Norio Nakamura, Masao Hattori, Xiu-Wei Yang, Chang-Ling Duan and Jian-Xun Liu
    Drug Metabolism and Disposition July 2004, 32 (7) 752-757; DOI: https://doi.org/10.1124/dmd.32.7.752
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    GLUCURONIDATION OF 1-NAPHTHOL AND EXCRETION INTO THE VEIN IN PERFUSED RAT KIDNEY
    Junichi Narukawa, Hiroki Inoue, Seiyu Kato and Hiroshi Yokota
    Drug Metabolism and Disposition July 2004, 32 (7) 758-761; DOI: https://doi.org/10.1124/dmd.32.7.758
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    BIOACTIVATION OF CAPECITABINE IN HUMAN LIVER: INVOLVEMENT OF THE CYTOSOLIC ENZYME ON 5′-DEOXY-5-FLUOROCYTIDINE FORMATION
    Toshiki Tabata, Miki Katoh, Shogo Tokudome, Masakiyo Hosakawa, Kan Chiba, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition July 2004, 32 (7) 762-767; DOI: https://doi.org/10.1124/dmd.32.7.762
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    HUMAN UDP-GLUCURONOSYLTRANSFERASES SHOW ATYPICAL METABOLISM OF MYCOPHENOLIC ACID AND INHIBITION BY CURCUMIN
    Nikhil K. Basu, Labanyamoy Kole, Shigeki Kubota and Ida S. Owens
    Drug Metabolism and Disposition July 2004, 32 (7) 768-773; DOI: https://doi.org/10.1124/dmd.32.7.768
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Drug Metabolism and Disposition: 32 (7)
Drug Metabolism and Disposition
Vol. 32, Issue 7
1 Jul 2004
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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