Drug Metabolism and Disposition: 32 (7)

July 01, 2004; Volume 32,Issue 7

Short Communications

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ROLE OF MOUSE CYP2E1 IN THE O-HYDROXYLATION OF P-NITROPHENOL: COMPARISON OF ACTIVITIES IN HEPATIC MICROSOMES FROM CYP2E1(-/-) AND WILD-TYPE MICE
Kristina K. Wolf, Sheryl G. Wood, Jenna L. Bement, Peter R. Sinclair, Steven A. Wrighton, Elizabeth Jeffery, Frank J. Gonzalez and Jacqueline F. Sinclair

Drug Metabolism and Disposition July 2004, 32 (7) 681-684; DOI: https://doi.org/10.1124/dmd.32.7.681
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C-JUN N-TERMINAL KINASE MODULATES 1,25-DIHYDROXYVITAMIN D₃-INDUCED CYTOCHROME P450 3A4 GENE EXPRESSION
Yoko Yasunami, Hirokazu Hara, Tatsunori Iwamura, Tadashi Kataoka and Tetsuo Adachi

Drug Metabolism and Disposition July 2004, 32 (7) 685-688; DOI: https://doi.org/10.1124/dmd.32.7.685

Articles

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METABOLISM AND EXCRETION OF CAPRAVIRINE, A NEW NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR, ALONE AND IN COMBINATION WITH RITONAVIR IN HEALTHY VOLUNTEERS
Hai-Zhi Bu, William F. Pool, Ellen Y. Wu, Susan R. Raber, Michael A. Amantea and Bhasker V. Shetty

Drug Metabolism and Disposition July 2004, 32 (7) 689-698; DOI: https://doi.org/10.1124/dmd.32.7.689
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FLUORESCENCE-BASED ASSAYS FOR SCREENING NINE CYTOCHROME P450 (P450) ACTIVITIES IN INTACT CELLS EXPRESSING INDIVIDUAL HUMAN P450 ENZYMES
M. Teresa Donato, Nuria Jiménez, José V. Castell and M. José Gómez-Lechón

Drug Metabolism and Disposition July 2004, 32 (7) 699-706; DOI: https://doi.org/10.1124/dmd.32.7.699
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INVOLVEMENT OF INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR α IN CYP3A11 AND 2C29 DOWN-REGULATION BY BACILLUS CALMETTE-GUÉRIN AND LIPOPOLYSACCHARIDE IN MOUSE LIVER
Takashi Ashino, Takiko Oguro, Seiji Shioda, Reiko Horai, Masahide Asano, Kenji Sekikawa, Yoichiro Iwakura, Satoshi Numazawa and Takemi Yoshida

Drug Metabolism and Disposition July 2004, 32 (7) 707-714; DOI: https://doi.org/10.1124/dmd.32.7.707
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AN EVALUATION OF THE IN VITRO METABOLISM DATA FOR PREDICTING THE CLEARANCE AND DRUG-DRUG INTERACTION POTENTIAL OF CYP2C9 SUBSTRATES
Tommy B. Andersson, Eva Bredberg, Hans Ericsson and Helena Sjöberg

Drug Metabolism and Disposition July 2004, 32 (7) 715-721; DOI: https://doi.org/10.1124/dmd.32.7.715
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THE SYSTEMIC EXPOSURE OF AN N-METHYL-d-ASPARTATE RECEPTOR ANTAGONIST IS LIMITED IN MICE BY THE P-GLYCOPROTEIN AND BREAST CANCER RESISTANCE PROTEIN EFFLUX TRANSPORTERS
Joseph W. Polli, Todd M. Baughman, Joan E. Humphreys, Kelly H. Jordan, Angela L. Mote, Lindsey O. Webster, Robert J. Barnaby, Giovanni Vitulli, Luigina Bertolotti, Kevin D. Read and Cosette J. Serabjit-Singh

Drug Metabolism and Disposition July 2004, 32 (7) 722-726; DOI: https://doi.org/10.1124/dmd.32.7.722
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THE EFFECT OF ISONIAZID ON CYP2E1- AND CYP4A-MEDIATED HYDROXYLATION OF ARACHIDONIC ACID IN THE RAT LIVER AND KIDNEY
Samuel M. Poloyac, Michael A. Tortorici, Danielle I. Przychodzin, Robert B. Reynolds, Wen Xie, Reginald F. Frye and Michael A. Zemaitis

Drug Metabolism and Disposition July 2004, 32 (7) 727-733; DOI: https://doi.org/10.1124/dmd.32.7.727
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LIPOPOLYSACCHARIDE-MEDIATED REGULATION OF HEPATIC TRANSPORTER mRNA LEVELS IN RATS
Nathan J. Cherrington, Angela L. Slitt, Ning Li and Curtis D. Klaassen

Drug Metabolism and Disposition July 2004, 32 (7) 734-741; DOI: https://doi.org/10.1124/dmd.32.7.734
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GLUCURONIDATION OF THE OXIDATIVE CYTOCHROME P450-MEDIATED PHENOLIC METABOLITES OF THE ENDOCRINE DISRUPTOR PESTICIDE: METHOXYCHLOR BY HUMAN HEPATIC UDP-GLUCURONOSYL TRANSFERASES
Eszter Hazai, Peter V. Gagne and David Kupfer

Drug Metabolism and Disposition July 2004, 32 (7) 742-751; DOI: https://doi.org/10.1124/dmd.32.7.742
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MAGNESIUM LITHOSPERMATE B IS EXCRETED RAPIDLY INTO RAT BILE MOSTLY AS METHYLATED METABOLITES, WHICH ARE POTENT ANTIOXIDANTS
Ying Zhang, Teruaki Akao, Norio Nakamura, Masao Hattori, Xiu-Wei Yang, Chang-Ling Duan and Jian-Xun Liu

Drug Metabolism and Disposition July 2004, 32 (7) 752-757; DOI: https://doi.org/10.1124/dmd.32.7.752
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GLUCURONIDATION OF 1-NAPHTHOL AND EXCRETION INTO THE VEIN IN PERFUSED RAT KIDNEY
Junichi Narukawa, Hiroki Inoue, Seiyu Kato and Hiroshi Yokota

Drug Metabolism and Disposition July 2004, 32 (7) 758-761; DOI: https://doi.org/10.1124/dmd.32.7.758
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BIOACTIVATION OF CAPECITABINE IN HUMAN LIVER: INVOLVEMENT OF THE CYTOSOLIC ENZYME ON 5′-DEOXY-5-FLUOROCYTIDINE FORMATION
Toshiki Tabata, Miki Katoh, Shogo Tokudome, Masakiyo Hosakawa, Kan Chiba, Miki Nakajima and Tsuyoshi Yokoi

Drug Metabolism and Disposition July 2004, 32 (7) 762-767; DOI: https://doi.org/10.1124/dmd.32.7.762
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HUMAN UDP-GLUCURONOSYLTRANSFERASES SHOW ATYPICAL METABOLISM OF MYCOPHENOLIC ACID AND INHIBITION BY CURCUMIN
Nikhil K. Basu, Labanyamoy Kole, Shigeki Kubota and Ida S. Owens

Drug Metabolism and Disposition July 2004, 32 (7) 768-773; DOI: https://doi.org/10.1124/dmd.32.7.768

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