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Research ArticleArticle

THE SYSTEMIC EXPOSURE OF AN N-METHYL-d-ASPARTATE RECEPTOR ANTAGONIST IS LIMITED IN MICE BY THE P-GLYCOPROTEIN AND BREAST CANCER RESISTANCE PROTEIN EFFLUX TRANSPORTERS

Joseph W. Polli, Todd M. Baughman, Joan E. Humphreys, Kelly H. Jordan, Angela L. Mote, Lindsey O. Webster, Robert J. Barnaby, Giovanni Vitulli, Luigina Bertolotti, Kevin D. Read and Cosette J. Serabjit-Singh
Drug Metabolism and Disposition July 2004, 32 (7) 722-726; DOI: https://doi.org/10.1124/dmd.32.7.722

Article Information

vol. 32 no. 7 722-726
DOI 
https://doi.org/10.1124/dmd.32.7.722
PubMed 
15205387
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 30, 2004
  • Accepted April 5, 2004
  • Published online June 17, 2004.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Joseph W. Polli,
  2. Todd M. Baughman,
  3. Joan E. Humphreys,
  4. Kelly H. Jordan,
  5. Angela L. Mote,
  6. Lindsey O. Webster,
  7. Robert J. Barnaby1,
  8. Giovanni Vitulli,
  9. Luigina Bertolotti,
  10. Kevin D. Read and
  11. Cosette J. Serabjit-Singh
  1. Preclinical DMPK (J.W.P., J.E.H., K.H.J., L.O.W., C.J.S.-S.) and Drug Discovery DMPK (T.M.B., A.L.M.), GlaxoSmithKline, Research Triangle Park, North Carolina; and Drug Discovery DMPK (R.J.B., G.V., K.D.R.) and Preclinical DMPK (L.B.), GlaxoSmithKline, Verona, Italy
  1. Address correspondence to:
    Dr. Joseph W. Polli, GlaxoSmithKline, Inc., P.O. Box 13398, Room: MAI.A2213, Research Triangle Park, NC 27709. E-mail: joseph.w.polli{at}gsk.com
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Research ArticleArticle

THE SYSTEMIC EXPOSURE OF AN N-METHYL-d-ASPARTATE RECEPTOR ANTAGONIST IS LIMITED IN MICE BY THE P-GLYCOPROTEIN AND BREAST CANCER RESISTANCE PROTEIN EFFLUX TRANSPORTERS

Joseph W. Polli, Todd M. Baughman, Joan E. Humphreys, Kelly H. Jordan, Angela L. Mote, Lindsey O. Webster, Robert J. Barnaby, Giovanni Vitulli, Luigina Bertolotti, Kevin D. Read and Cosette J. Serabjit-Singh
Drug Metabolism and Disposition July 1, 2004, 32 (7) 722-726; DOI: https://doi.org/10.1124/dmd.32.7.722
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