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Drug Metabolism & Disposition

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Table of Contents

August 01, 2004; Volume 32,Issue 8

Short Communications

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    THE MAIN ROLE OF UGT1A9 IN THE HEPATIC METABOLISM OF MYCOPHENOLIC ACID AND THE EFFECTS OF NATURALLY OCCURRING VARIANTS
    Olivier Bernard and Chantal Guillemette
    Drug Metabolism and Disposition August 2004, 32 (8) 775-778; DOI: https://doi.org/10.1124/dmd.32.8.775
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    LEVOTHYROXINE UP-REGULATES P-GLYCOPROTEIN INDEPENDENT OF THE PREGNANE X RECEPTOR
    Tim Mitin, Lisa L. von Moltke, Michael H. Court and David J. Greenblatt
    Drug Metabolism and Disposition August 2004, 32 (8) 779-782; DOI: https://doi.org/10.1124/dmd.32.8.779
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    INSECT REPELLANT INTERACTIONS: SUNSCREENS ENHANCE DEET (N,N-DIETHYL-M-TOLUAMIDE) ABSORPTION
    Edward A. Ross, Kathleen A. Savage, Luke J. Utley and Ian R. Tebbett
    Drug Metabolism and Disposition August 2004, 32 (8) 783-785; DOI: https://doi.org/10.1124/dmd.32.8.783

Articles

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    EFFECTS OF PROTEIN CALORIE MALNUTRITION ON THE PHARMACOKINETICS OF KETAMINE IN RATS
    Marion L. Williams, Donald E. Mager, Heli Parenteau, Girish Gudi, Timothy S. Tracy, Mike Mulheran and Irving W. Wainer
    Drug Metabolism and Disposition August 2004, 32 (8) 786-793; DOI: https://doi.org/10.1124/dmd.32.8.786
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    THE HEPATIC PHARMACOKINETICS OF DOXORUBICIN AND LIPOSOMAL DOXORUBICIN
    Sarah N. Hilmer, Victoria C. Cogger, Michael Muller and David G. Le Couteur
    Drug Metabolism and Disposition August 2004, 32 (8) 794-799; DOI: https://doi.org/10.1124/dmd.32.8.794
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    INTERACTION OF TRIAZOLAM AND KETOCONAZOLE IN P-GLYCOPROTEIN-DEFICIENT MICE
    Lisa L. von Moltke, Brian W. Granda, Jeffrey M. Grassi, Michael D. Perloff, Daesety Vishnuvardhan and David J. Greenblatt
    Drug Metabolism and Disposition August 2004, 32 (8) 800-804; DOI: https://doi.org/10.1124/dmd.32.8.800
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    INHIBITION OF MURINE CYTOCHROME P4501A BY TACRINE: IN VITRO STUDIES
    Joanna Z. Peng, Rory P. Remmel and Ronald J. Sawchuk
    Drug Metabolism and Disposition August 2004, 32 (8) 805-812; DOI: https://doi.org/10.1124/dmd.32.8.805
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    HUMAN PLACENTAL GLUCURONIDATION AND TRANSPORT OF 3′AZIDO-3′-DEOXYTHYMIDINE AND URIDINE DIPHOSPHATE GLUCURONIC ACID
    Abby C. Collier, Jeffrey A. Keelan, Pierre E. van Zijl, James W. Paxton, Murray D. Mitchell and Malcolm D. Tingle
    Drug Metabolism and Disposition August 2004, 32 (8) 813-820; DOI: https://doi.org/10.1124/dmd.32.8.813
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    COMPARISON OF INHIBITORY EFFECTS OF THE PROTON PUMP-INHIBITING DRUGS OMEPRAZOLE, ESOMEPRAZOLE, LANSOPRAZOLE, PANTOPRAZOLE, AND RABEPRAZOLE ON HUMAN CYTOCHROME P450 ACTIVITIES
    Xue-Qing Li, Tommy B. Andersson, Marie Ahlström and Lars Weidolf
    Drug Metabolism and Disposition August 2004, 32 (8) 821-827; DOI: https://doi.org/10.1124/dmd.32.8.821
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    INHIBITORY EFFECTS OF POMELO ON THE METABOLISM OF TACROLIMUS AND THE ACTIVITIES OF CYP3A4 AND P-GLYCOPROTEIN
    Kanoko Egashira, Hisakazu Ohtani, Suwako Itoh, Noriko Koyabu, Masayuki Tsujimoto, Hideyasu Murakami and Yasufumi Sawada
    Drug Metabolism and Disposition August 2004, 32 (8) 828-833; DOI: https://doi.org/10.1124/dmd.32.8.828
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    EFFECT OF DEXAMETHASONE TREATMENT ON THE EXPRESSION AND FUNCTION OF TRANSPORT PROTEINS IN SANDWICH-CULTURED RAT HEPATOCYTES
    Ryan Z. Turncliff, Peter J. Meier and Kim L. R. Brouwer
    Drug Metabolism and Disposition August 2004, 32 (8) 834-839; DOI: https://doi.org/10.1124/dmd.32.8.834
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    METABOLISM OF RETINOIDS AND ARACHIDONIC ACID BY HUMAN AND MOUSE CYTOCHROME P450 1B1
    Dharamainder Choudhary, Ingela Jansson, Ivaylo Stoilov, Mansoor Sarfarazi and John B. Schenkman
    Drug Metabolism and Disposition August 2004, 32 (8) 840-847; DOI: https://doi.org/10.1124/dmd.32.8.840
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    IN VITRO AND IN VIVO METABOLISM OF A POTENT AND SELECTIVE INTEGRIN αvβ3 ANTAGONIST IN RATS, DOGS, AND MONKEYS
    Donghui Cui, Raju Subramanian, Magang Shou, Xiao Yu, Michael A. Wallace, Matthew P. Braun, Byron H. Arison, James A. Yergey and Thomayant Prueksaritanont
    Drug Metabolism and Disposition August 2004, 32 (8) 848-861; DOI: https://doi.org/10.1124/dmd.32.8.848
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    EVALUATION OF 5-HYDROXYTRYPTOPHOL AND OTHER ENDOGENOUS SEROTONIN (5-HYDROXYTRYPTAMINE) ANALOGS AS SUBSTRATES FOR UDP-GLUCURONOSYLTRANSFERASE 1A6
    Soundararajan Krishnaswamy, Qin Hao, Lisa L. von Moltke, David J. Greenblatt and Michael H. Court
    Drug Metabolism and Disposition August 2004, 32 (8) 862-869; DOI: https://doi.org/10.1124/dmd.32.8.862
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    SEQUENTIAL METABOLISM OF 2,3,7-TRICHLORODIBENZO-P-DIOXIN (2,3,7-triCDD) BY CYTOCHROME P450 AND UDP-GLUCURONOSYLTRANSFERASE IN HUMAN LIVER MICROSOMES
    Noriyuki Kasai, Toshiyuki Sakaki, Raku Shinkyo, Shin-ichi Ikushiro, Takashi Iyanagi, Maya Kamao, Toshio Okano, Miho Ohta and Kuniyo Inouye
    Drug Metabolism and Disposition August 2004, 32 (8) 870-875; DOI: https://doi.org/10.1124/dmd.32.8.870
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    NADPH-DEPENDENT FORMATION OF POLAR AND NONPOLAR ESTROGEN METABOLITES FOLLOWING INCUBATIONS OF 17β-ESTRADIOL WITH HUMAN LIVER MICROSOMES
    Anthony J. Lee and Bao Ting Zhu
    Drug Metabolism and Disposition August 2004, 32 (8) 876-883; DOI: https://doi.org/10.1124/dmd.32.8.876
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    MODELING THE IN VITRO INTRINSIC CLEARANCE OF THE SLOWLY METABOLIZED COMPOUND TOLBUTAMIDE DETERMINED IN SANDWICH-CULTURED RAT HEPATOCYTES
    Nicoline Treijtel, Arjan Barendregt, Andreas P. Freidig, Bas J. Blaauboer and Jan C. H. van Eijkeren
    Drug Metabolism and Disposition August 2004, 32 (8) 884-891; DOI: https://doi.org/10.1124/dmd.32.8.884
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Drug Metabolism and Disposition: 32 (8)
Drug Metabolism and Disposition
Vol. 32, Issue 8
1 Aug 2004
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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