COMPARISON OF INHIBITORY EFFECTS OF THE PROTON PUMP-INHIBITING DRUGS OMEPRAZOLE, ESOMEPRAZOLE, LANSOPRAZOLE, PANTOPRAZOLE, AND RABEPRAZOLE ON HUMAN CYTOCHROME P450 ACTIVITIES

Address correspondence to:
Dr. Lars Weidolf, DMPK and Bioanalytical Chemistry, AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden. E-mail: lars.weidolf{at}astrazeneca.com.

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	Abstract	Full	Pdf
Jul 2004	117	144	150
Aug 2004	109	219	172
Sep 2004	110	198	102
Oct 2004	98	164	74
Nov 2004	81	120	54
Dec 2004	51	119	43
Jan 2005	74	126	54
Feb 2005	66	158	55
Mar 2005	57	180	71
Apr 2005	67	181	55
May 2005	69	187	43
Jun 2005	88	145	32
Jul 2005	64	148	30
Aug 2005	52	159	107
Sep 2005	51	184	121
Oct 2005	54	176	115
Nov 2005	46	195	100
Dec 2005	33	121	93
Jan 2006	80	200	110
Feb 2006	58	162	68
Mar 2006	58	157	79
Apr 2006	35	133	71
May 2006	36	150	74
Jun 2006	46	121	69
Jul 2006	49	103	59
Aug 2006	90	102	82
Sep 2006	52	117	85
Oct 2006	62	106	82
Nov 2006	77	108	88
Dec 2006	57	92	78
Jan 2007	71	112	104
Feb 2007	64	119	111
Mar 2007	86	98	104
Apr 2007	85	140	96
May 2007	77	106	94
Jun 2007	70	97	85
Jul 2007	77	113	86
Aug 2007	72	90	60
Sep 2007	85	101	73
Oct 2007	76	129	78
Nov 2007	62	108	75
Dec 2007	41	79	45
Jan 2008	49	107	73
Feb 2008	44	111	69
Mar 2008	58	115	79
Apr 2008	77	108	75
May 2008	69	95	56
Jun 2008	45	95	70
Jul 2008	65	107	64
Aug 2008	81	78	71
Sep 2008	57	82	78
Oct 2008	68	82	72
Nov 2008	92	84	105
Dec 2008	69	76	65
Jan 2009	103	92	106
Feb 2009	140	226	281
Mar 2009	159	287	368
Apr 2009	155	246	289
May 2009	150	209	222
Jun 2009	180	226	254
Jul 2009	178	188	189
Aug 2009	169	231	224
Sep 2009	186	218	186
Oct 2009	193	171	164
Nov 2009	162	159	174
Dec 2009	163	116	147
Jan 2010	293	160	170
Feb 2010	331	176	206
Mar 2010	419	212	227
Apr 2010	351	146	165
May 2010	334	185	190
Jun 2010	335	183	154
Jul 2010	326	167	149
Aug 2010	302	153	132
Sep 2010	323	221	159
Oct 2010	362	216	160
Nov 2010	305	231	167
Dec 2010	229	139	108
Jan 2011	311	190	164
Feb 2011	300	196	127
Mar 2011	362	184	172
Apr 2011	306	168	158
May 2011	322	192	133
Jun 2011	287	189	170
Jul 2011	297	163	171
Aug 2011	354	221	212
Sep 2011	459	278	232
Oct 2011	432	329	196
Nov 2011	410	338	192
Dec 2011	345	275	167
Jan 2012	375	409	187
Feb 2012	347	465	158
Mar 2012	373	440	230
Apr 2012	341	372	153
May 2012	391	394	204
Jun 2012	331	332	171
Jul 2012	308	374	171
Aug 2012	256	308	142
Sep 2012	273	386	192
Oct 2012	378	448	189
Nov 2012	328	398	173
Dec 2012	295	386	135
Jan 2013	316	379	161
Feb 2013	278	375	124
Mar 2013	229	345	143
Apr 2013	259	473	189
May 2013	285	412	156
Jun 2013	230	364	142
Jul 2013	253	400	131
Aug 2013	204	432	111
Sep 2013	530	394	160
Oct 2013	877	378	147
Nov 2013	768	414	145
Dec 2013	269	431	134
Jan 2014	298	498	152
Feb 2014	211	514	159
Mar 2014	322	630	213
Apr 2014	302	566	197
May 2014	305	621	159
Jun 2014	214	702	159
Jul 2014	141	605	159
Aug 2014	125	662	148
Sep 2014	83	666	144
Oct 2014	125	473	139
Nov 2014	103	680	133
Dec 2014	67	574	119
Jan 2015	110	647	118
Feb 2015	243	503	155
Mar 2015	337	623	192
Apr 2015	282	496	172
May 2015	256	588	147
Jun 2015	241	491	150
Jul 2015	247	511	148
Aug 2015	223	382	110
Sep 2015	214	440	149
Oct 2015	261	413	141
Nov 2015	317	432	158
Dec 2015	258	422	101
Jan 2016	273	435	150
Feb 2016	198	417	125
Mar 2016	280	433	144
Apr 2016	251	470	137
May 2016	304	586	141
Jun 2016	244	401	145
Jul 2016	234	378	153
Aug 2016	229	395	130
Sep 2016	204	273	107
Oct 2016	189	275	130
Nov 2016	177	269	151
Dec 2016	159	247	92
Jan 2017	176	299	98
Feb 2017	158	406	154
Mar 2017	174	298	148
Apr 2017	181	192	99
May 2017	176	195	121
Jun 2017	117	177	127
Jul 2017	151	175	121
Aug 2017	126	245	141
Sep 2017	131	265	121
Oct 2017	168	281	123
Nov 2017	172	389	128
Dec 2017	118	210	91
Jan 2018	148	225	118
Feb 2018	162	212	93
Mar 2018	177	274	117
Apr 2018	130	253	124
May 2018	95	227	100
Jun 2018	80	234	88
Jul 2018	94	156	183
Aug 2018	91	153	118
Sep 2018	105	195	102
Oct 2018	127	232	138
Nov 2018	122	184	152
Dec 2018	350	52	59
Jan 2019	351	20	21
Feb 2019	346	17	13
Mar 2019	309	21	19
Apr 2019	314	14	7
May 2019	301	20	14
Jun 2019	236	18	19
Jul 2019	253	26	21
Aug 2019	224	18	18
Sep 2019	297	18	17
Oct 2019	353	23	21
Nov 2019	254	14	25
Dec 2019	253	23	18
Jan 2020	238	11	13
Feb 2020	179	24	13
Mar 2020	198	19	19
Apr 2020	241	11	8
May 2020	271	14	11
Jun 2020	169	15	12
Jul 2020	167	13	9
Aug 2020	169	10	11
Sep 2020	158	7	11
Oct 2020	209	20	28
Nov 2020	239	19	12
Dec 2020	210	21	14
Jan 2021	146	38	8
Feb 2021	193	30	10
Mar 2021	336	27	17
Apr 2021	235	28	22
May 2021	256	26	10
Jun 2021	227	36	19
Jul 2021	193	18	11
Aug 2021	202	26	17
Sep 2021	211	17	10
Oct 2021	124	8	6