Table of Contents

Articles

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  DIFFERENCES IN THE PHARMACOKINETICS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR AGONISTS IN GENETICALLY OBESE ZUCKER AND SPRAGUE-DAWLEY RATS: IMPLICATIONS OF DECREASED GLUCURONIDATION IN OBESE ZUCKER RATS

  Mi-Sook Kim, Sui Wang, Zhongzhou Shen, Christopher J. Kochansky, John R. Strauss, Ronald B. Franklin and Stella H. Vincent

  Drug Metabolism and Disposition September 2004, 32 (9) 909-914;
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  ENANTIOSELECTIVITY OF CARBONYL REDUCTION OF 4-METHYLNITROSAMINO-1-(3-PYRIDYL)-1-BUTANONE BY TISSUE FRACTIONS FROM HUMAN AND RAT AND BY ENZYMES ISOLATED FROM HUMAN LIVER

  Ursula Breyer-Pfaff, Hans-Jörg Martin, Michael Ernst and Edmund Maser

  Drug Metabolism and Disposition September 2004, 32 (9) 915-922;
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  PHARMACOKINETICS AND METABOLISM OF TESAGLITAZAR, A NOVEL DUAL-ACTING PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α/γ AGONIST, AFTER A SINGLE ORAL AND INTRAVENOUS DOSE IN HUMANS

  H. Ericsson, B. Hamrén, S. Bergstrand, M. Elebring, L. Fryklund, M. Heijer and K. P. Öhman

  Drug Metabolism and Disposition September 2004, 32 (9) 923-929;
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  CYP2B6, CYP3A4, AND CYP2C19 ARE RESPONSIBLE FOR THE IN VITRO N-DEMETHYLATION OF MEPERIDINE IN HUMAN LIVER MICROSOMES

  Jacqueline Ramírez, Federico Innocenti, Erin G. Schuetz, David A. Flockhart, Mary V. Relling, Raymond Santucci and Mark J. Ratain

  Drug Metabolism and Disposition September 2004, 32 (9) 930-936;
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  EVALUATION OF A NOVEL IN VITRO CACO-2 HEPATOCYTE HYBRID SYSTEM FOR PREDICTING IN VIVO ORAL BIOAVAILABILITY

  Yau Yi Lau, Yung-Hsiang Chen, Tong-tong Liu, Cheng Li, Xiaoming Cui, Ronald E. White and K.-C. Cheng

  Drug Metabolism and Disposition September 2004, 32 (9) 937-942;
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  IDENTIFICATION OF AN N-METHYL-4-PHENYLPYRIDINIUM-LIKE METABOLITE OF THE ANTIDIARRHEAL AGENT LOPERAMIDE IN HUMAN LIVER MICROSOMES: UNDERLYING REASON(S) FOR THE LACK OF NEUROTOXICITY DESPITE THE BIOACTIVATION EVENT

  Amit S. Kalgutkar and Hang T. Nguyen

  Drug Metabolism and Disposition September 2004, 32 (9) 943-952;
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  KINETIC CHARACTERIZATION OF P-GLYCOPROTEIN-MEDIATED EFFLUX OF RHODAMINE 6G IN THE INTACT RABBIT LUNG

  David L. Roerig, Said H. Audi and Susan B. Ahlf

  Drug Metabolism and Disposition September 2004, 32 (9) 953-958; DOI: https://doi.org/10.1124/dmd.104.000042
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  STRAIN DIFFERENCES IN DIAZEPAM METABOLISM AT ITS THREE METABOLIC SITES IN SPRAGUE-DAWLEY, BROWN NORWAY, DARK AGOUTI, AND WISTAR STRAIN RATS

  Konomu Saito, Noriaki Sakai, Hyung-Sub Kim, Mayumi Ishizuka, Akio Kazusaka and Shoichi Fujita

  Drug Metabolism and Disposition September 2004, 32 (9) 959-965;
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  SELECTIVE REDUCTION OF N-OXIDES TO AMINES: APPLICATION TO DRUG METABOLISM

  Palaniappan Kulanthaivel, Robert J. Barbuch, Rita S. Davidson, Ping Yi, Gregory A. Rener, Edward L. Mattiuz, Chad E. Hadden, Lawrence A. Goodwin and William J. Ehlhardt

  Drug Metabolism and Disposition September 2004, 32 (9) 966-972;
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  SUBSTRATE DEPLETION APPROACH FOR DETERMINING IN VITRO METABOLIC CLEARANCE: TIME DEPENDENCIES IN HEPATOCYTE AND MICROSOMAL INCUBATIONS

  Hannah M. Jones and J. Brian Houston

  Drug Metabolism and Disposition September 2004, 32 (9) 973-982; DOI: https://doi.org/10.1124/dmd.104.000125
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  EFFECT OF POLY(ETHYLENE IMINE) MOLECULAR WEIGHT AND PEGYLATION ON ORGAN DISTRIBUTION AND PHARMACOKINETICS OF POLYPLEXES WITH OLIGODEOXYNUCLEOTIDES IN MICE

  Dagmar Fischer, Berit Osburg, Holger Petersen, Thomas Kissel and Ulrich Bickel

  Drug Metabolism and Disposition September 2004, 32 (9) 983-992;
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  KINETICS AND REGULATION OF CYTOCHROME P450-MEDIATED ETOPOSIDE METABOLISM

  Xiaoliang Zhuo, Naiyu Zheng, Carolyn A. Felix and Ian A. Blair

  Drug Metabolism and Disposition September 2004, 32 (9) 993-1000;
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  STEREOCHEMICAL ANALYSIS OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE AND ITS MAIN METABOLITES IN HUMAN SAMPLES INCLUDING THE CATECHOL-TYPE METABOLITE (3,4-DIHYDROXYMETHAMPHETAMINE)

  Nieves Pizarro, Magí Farré, Mitona Pujadas, Ana Ma͢ Peiró, Pere N Roset, Jesús Joglar and Rafael de la Torre

  Drug Metabolism and Disposition September 2004, 32 (9) 1001-1007;
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  EFFECT OF PROTOTYPICAL INDUCING AGENTS ON P-GLYCOPROTEIN AND CYP3A EXPRESSION IN MOUSE TISSUES

  Christopher J. Matheny, Rabia Y. Ali, Xiaodong Yang and Gary M. Pollack

  Drug Metabolism and Disposition September 2004, 32 (9) 1008-1014;
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  IN VITRO METABOLISM OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL) PHENYL]METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α/γ AGONIST. I. ROLE OF CYTOCHROME P450, METHYLTRANSFERASES, FLAVIN MONOOXYGENASES, AND ESTERASES

  Bindhu V. Karanam, Cornelis E.C.A. Hop, David Q. Liu, Mike Wallace, Dennis Dean, Hiroya Satoh, Masakatsu Komuro, Katsuya Awano and Stella H. Vincent

  Drug Metabolism and Disposition September 2004, 32 (9) 1015-1022; DOI: https://doi.org/10.1124/dmd.104.000034
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  IN VITRO METABOLISM OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL)-PHENYL] METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α/γ AGONIST. II. IDENTIFICATION OF METABOLITES BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

  David Q. Liu, Bindhu V. Karanam, George A. Doss, Rick R. Sidler, Stella H. Vincent and Cornelis E.C.A. Hop

  Drug Metabolism and Disposition September 2004, 32 (9) 1023-1031; DOI: https://doi.org/10.1124/dmd.104.000059
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  BIOACTIVATION OF 1,1-DICHLOROETHYLENE TO ITS EPOXIDE BY CYP2E1 AND CYP2F ENZYMES

  Andrea C. Simmonds, Christopher A. Reilly, R. Michael Baldwin, Burhan I. Ghanayem, Diane L. Lanza, Garold S. Yost, Kathy S. Collins and Poh-Gek Forkert

  Drug Metabolism and Disposition September 2004, 32 (9) 1032-1039;
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  CARRIER-MEDIATED UPTAKE OF H₂-RECEPTOR ANTAGONISTS BY THE RAT CHOROID PLEXUS: INVOLVEMENT OF RAT ORGANIC ANION TRANSPORTER 3

  Yoshinori Nagata, Hiroyuki Kusuhara, Shuichi Hirono, Hitoshi Endou and Yuichi Sugiyama

  Drug Metabolism and Disposition September 2004, 32 (9) 1040-1047;
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  SINGLE NUCLEOTIDE POLYMORPHISMS AND HAPLOTYPE FREQUENCIES OF UGT2B4 AND UGT2B7 IN A JAPANESE POPULATION

  Mayumi Saeki, Yoshiro Saito, Hideto Jinno, Toshiko Tanaka-Kagawa, Akiko Ohno, Shogo Ozawa, Kazuyuki Ueno, Shiro Kamakura, Naoyuki Kamatani, Kazuo Komamura, Masafumi Kitakaze and Jun-ichi Sawada

  Drug Metabolism and Disposition September 2004, 32 (9) 1048-1054;