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Drug Metabolism & Disposition

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Table of Contents

September 01, 2004; Volume 32,Issue 9

Short Communications

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    CERAMIDE, AN APOPTOTIC RHEOSTAT, INHIBITS CCAAT/ENHANCER BINDING PROTEIN-β AND NF-E2-RELATED FACTOR-2 ACTIVATION: THE ROLE IN GLUTATHIONE S-TRANSFERASE A2 GENE REPRESSION
    I-Na Park, Il Je Cho and Sang Geon Kim
    Drug Metabolism and Disposition September 2004, 32 (9) 893-897;
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    IMPAIRED RENAL EXCRETION OF 6-HYDROXY-5,7-DIMETHYL-2-METHYLAMINO-4-(3-PYRIDYLMETHYL) BENZOTHIAZOLE (E3040) SULFATE IN BREAST CANCER RESISTANCE PROTEIN (BCRP1/ABCG2) KNOCKOUT MICE
    Naomi Mizuno, Michiko Suzuki, Hiroyuki Kusuhara, Hiroshi Suzuki, Kenji Takeuchi, Takuro Niwa, Johan W. Jonker and Yuichi Sugiyama
    Drug Metabolism and Disposition September 2004, 32 (9) 898-901;
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    ALTERED PHARMACOKINETICS OF OMEPRAZOLE IN CYSTIC FIBROSIS KNOCKOUT MICE RELATIVE TO WILD-TYPE MICE
    Melanie N. Tallman, Shazia Y. Ali and Philip C. Smith
    Drug Metabolism and Disposition September 2004, 32 (9) 902-905;
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    GREEN TEA (CAMELLIA SINENSIS) EXTRACT DOES NOT ALTER CYTOCHROME P450 3A4 OR 2D6 ACTIVITY IN HEALTHY VOLUNTEERS
    Jennifer L. Donovan, Kenneth D. Chavin, C. Lindsay Devane, Robin M. Taylor, Jun-Sheng Wang, Ying Ruan and John S. Markowitz
    Drug Metabolism and Disposition September 2004, 32 (9) 906-908; DOI: https://doi.org/10.1124/dmd.104.000083

Articles

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    DIFFERENCES IN THE PHARMACOKINETICS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR AGONISTS IN GENETICALLY OBESE ZUCKER AND SPRAGUE-DAWLEY RATS: IMPLICATIONS OF DECREASED GLUCURONIDATION IN OBESE ZUCKER RATS
    Mi-Sook Kim, Sui Wang, Zhongzhou Shen, Christopher J. Kochansky, John R. Strauss, Ronald B. Franklin and Stella H. Vincent
    Drug Metabolism and Disposition September 2004, 32 (9) 909-914;
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    ENANTIOSELECTIVITY OF CARBONYL REDUCTION OF 4-METHYLNITROSAMINO-1-(3-PYRIDYL)-1-BUTANONE BY TISSUE FRACTIONS FROM HUMAN AND RAT AND BY ENZYMES ISOLATED FROM HUMAN LIVER
    Ursula Breyer-Pfaff, Hans-Jörg Martin, Michael Ernst and Edmund Maser
    Drug Metabolism and Disposition September 2004, 32 (9) 915-922;
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    PHARMACOKINETICS AND METABOLISM OF TESAGLITAZAR, A NOVEL DUAL-ACTING PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α/γ AGONIST, AFTER A SINGLE ORAL AND INTRAVENOUS DOSE IN HUMANS
    H. Ericsson, B. Hamrén, S. Bergstrand, M. Elebring, L. Fryklund, M. Heijer and K. P. Öhman
    Drug Metabolism and Disposition September 2004, 32 (9) 923-929;
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    CYP2B6, CYP3A4, AND CYP2C19 ARE RESPONSIBLE FOR THE IN VITRO N-DEMETHYLATION OF MEPERIDINE IN HUMAN LIVER MICROSOMES
    Jacqueline Ramírez, Federico Innocenti, Erin G. Schuetz, David A. Flockhart, Mary V. Relling, Raymond Santucci and Mark J. Ratain
    Drug Metabolism and Disposition September 2004, 32 (9) 930-936;
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    EVALUATION OF A NOVEL IN VITRO CACO-2 HEPATOCYTE HYBRID SYSTEM FOR PREDICTING IN VIVO ORAL BIOAVAILABILITY
    Yau Yi Lau, Yung-Hsiang Chen, Tong-tong Liu, Cheng Li, Xiaoming Cui, Ronald E. White and K.-C. Cheng
    Drug Metabolism and Disposition September 2004, 32 (9) 937-942;
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    IDENTIFICATION OF AN N-METHYL-4-PHENYLPYRIDINIUM-LIKE METABOLITE OF THE ANTIDIARRHEAL AGENT LOPERAMIDE IN HUMAN LIVER MICROSOMES: UNDERLYING REASON(S) FOR THE LACK OF NEUROTOXICITY DESPITE THE BIOACTIVATION EVENT
    Amit S. Kalgutkar and Hang T. Nguyen
    Drug Metabolism and Disposition September 2004, 32 (9) 943-952;
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    KINETIC CHARACTERIZATION OF P-GLYCOPROTEIN-MEDIATED EFFLUX OF RHODAMINE 6G IN THE INTACT RABBIT LUNG
    David L. Roerig, Said H. Audi and Susan B. Ahlf
    Drug Metabolism and Disposition September 2004, 32 (9) 953-958; DOI: https://doi.org/10.1124/dmd.104.000042
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    STRAIN DIFFERENCES IN DIAZEPAM METABOLISM AT ITS THREE METABOLIC SITES IN SPRAGUE-DAWLEY, BROWN NORWAY, DARK AGOUTI, AND WISTAR STRAIN RATS
    Konomu Saito, Noriaki Sakai, Hyung-Sub Kim, Mayumi Ishizuka, Akio Kazusaka and Shoichi Fujita
    Drug Metabolism and Disposition September 2004, 32 (9) 959-965;
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    SELECTIVE REDUCTION OF N-OXIDES TO AMINES: APPLICATION TO DRUG METABOLISM
    Palaniappan Kulanthaivel, Robert J. Barbuch, Rita S. Davidson, Ping Yi, Gregory A. Rener, Edward L. Mattiuz, Chad E. Hadden, Lawrence A. Goodwin and William J. Ehlhardt
    Drug Metabolism and Disposition September 2004, 32 (9) 966-972;
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    SUBSTRATE DEPLETION APPROACH FOR DETERMINING IN VITRO METABOLIC CLEARANCE: TIME DEPENDENCIES IN HEPATOCYTE AND MICROSOMAL INCUBATIONS
    Hannah M. Jones and J. Brian Houston
    Drug Metabolism and Disposition September 2004, 32 (9) 973-982; DOI: https://doi.org/10.1124/dmd.104.000125
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    EFFECT OF POLY(ETHYLENE IMINE) MOLECULAR WEIGHT AND PEGYLATION ON ORGAN DISTRIBUTION AND PHARMACOKINETICS OF POLYPLEXES WITH OLIGODEOXYNUCLEOTIDES IN MICE
    Dagmar Fischer, Berit Osburg, Holger Petersen, Thomas Kissel and Ulrich Bickel
    Drug Metabolism and Disposition September 2004, 32 (9) 983-992;
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    KINETICS AND REGULATION OF CYTOCHROME P450-MEDIATED ETOPOSIDE METABOLISM
    Xiaoliang Zhuo, Naiyu Zheng, Carolyn A. Felix and Ian A. Blair
    Drug Metabolism and Disposition September 2004, 32 (9) 993-1000;
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    STEREOCHEMICAL ANALYSIS OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE AND ITS MAIN METABOLITES IN HUMAN SAMPLES INCLUDING THE CATECHOL-TYPE METABOLITE (3,4-DIHYDROXYMETHAMPHETAMINE)
    Nieves Pizarro, Magí Farré, Mitona Pujadas, Ana Ma͢ Peiró, Pere N Roset, Jesús Joglar and Rafael de la Torre
    Drug Metabolism and Disposition September 2004, 32 (9) 1001-1007;
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    EFFECT OF PROTOTYPICAL INDUCING AGENTS ON P-GLYCOPROTEIN AND CYP3A EXPRESSION IN MOUSE TISSUES
    Christopher J. Matheny, Rabia Y. Ali, Xiaodong Yang and Gary M. Pollack
    Drug Metabolism and Disposition September 2004, 32 (9) 1008-1014;
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    IN VITRO METABOLISM OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL) PHENYL]METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α/γ AGONIST. I. ROLE OF CYTOCHROME P450, METHYLTRANSFERASES, FLAVIN MONOOXYGENASES, AND ESTERASES
    Bindhu V. Karanam, Cornelis E.C.A. Hop, David Q. Liu, Mike Wallace, Dennis Dean, Hiroya Satoh, Masakatsu Komuro, Katsuya Awano and Stella H. Vincent
    Drug Metabolism and Disposition September 2004, 32 (9) 1015-1022; DOI: https://doi.org/10.1124/dmd.104.000034
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    IN VITRO METABOLISM OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL)-PHENYL] METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α/γ AGONIST. II. IDENTIFICATION OF METABOLITES BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
    David Q. Liu, Bindhu V. Karanam, George A. Doss, Rick R. Sidler, Stella H. Vincent and Cornelis E.C.A. Hop
    Drug Metabolism and Disposition September 2004, 32 (9) 1023-1031; DOI: https://doi.org/10.1124/dmd.104.000059
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    BIOACTIVATION OF 1,1-DICHLOROETHYLENE TO ITS EPOXIDE BY CYP2E1 AND CYP2F ENZYMES
    Andrea C. Simmonds, Christopher A. Reilly, R. Michael Baldwin, Burhan I. Ghanayem, Diane L. Lanza, Garold S. Yost, Kathy S. Collins and Poh-Gek Forkert
    Drug Metabolism and Disposition September 2004, 32 (9) 1032-1039;
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    CARRIER-MEDIATED UPTAKE OF H2-RECEPTOR ANTAGONISTS BY THE RAT CHOROID PLEXUS: INVOLVEMENT OF RAT ORGANIC ANION TRANSPORTER 3
    Yoshinori Nagata, Hiroyuki Kusuhara, Shuichi Hirono, Hitoshi Endou and Yuichi Sugiyama
    Drug Metabolism and Disposition September 2004, 32 (9) 1040-1047;
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    SINGLE NUCLEOTIDE POLYMORPHISMS AND HAPLOTYPE FREQUENCIES OF UGT2B4 AND UGT2B7 IN A JAPANESE POPULATION
    Mayumi Saeki, Yoshiro Saito, Hideto Jinno, Toshiko Tanaka-Kagawa, Akiko Ohno, Shogo Ozawa, Kazuyuki Ueno, Shiro Kamakura, Naoyuki Kamatani, Kazuo Komamura, Masafumi Kitakaze and Jun-ichi Sawada
    Drug Metabolism and Disposition September 2004, 32 (9) 1048-1054;

Erratum

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    CORRECTION TO “GLUCURONIDATION OF THE OXIDATIVE CYTOCHROME P450-MEDIATED PHENOLIC METABOLITES OF THE ENDOCRINE DISRUPTOR PESTICIDE: METHOXYCHLOR BY HUMAN HEPATIC UDP-GLUCURONOSYL TRANSFERASES”
    Drug Metabolism and Disposition September 2004, 32 (9) 1055;
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Drug Metabolism and Disposition: 32 (9)
Drug Metabolism and Disposition
Vol. 32, Issue 9
1 Sep 2004
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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