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Research ArticleArticle

CYP2B6, CYP3A4, AND CYP2C19 ARE RESPONSIBLE FOR THE IN VITRO N-DEMETHYLATION OF MEPERIDINE IN HUMAN LIVER MICROSOMES

Jacqueline Ramírez, Federico Innocenti, Erin G. Schuetz, David A. Flockhart, Mary V. Relling, Raymond Santucci and Mark J. Ratain
Drug Metabolism and Disposition September 2004, 32 (9) 930-936;

Article Information

vol. 32 no. 9 930-936
PubMed 
15319333
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 23, 2004
  • Accepted May 27, 2004
  • Published online August 18, 2004.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jacqueline Ramírez,
  2. Federico Innocenti,
  3. Erin G. Schuetz,
  4. David A. Flockhart,
  5. Mary V. Relling,
  6. Raymond Santucci and
  7. Mark J. Ratain
  1. Department of Medicine, University of Chicago, Chicago, Illinois (J.R., R.S.); Department of Medicine, Cancer Research Center, Committee on Clinical Pharmacology and Pharmacogenomicsg, University of Chicago, Chicago, Illinois (F.I., M.J.R.); Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (E.G.S., M.V.R.); and Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana (D.A.F.)
  1. Address correspondence to:
    Dr. Mark J. Ratain, University of Chicago, Department of Medicine, Section of Hematology-Oncology, 5841 S. Maryland Avenue, MC2115, Chicago, IL 60637. E-mail: mratain{at}medicine.bsd.uchicago.edu
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Research ArticleArticle

CYP2B6, CYP3A4, AND CYP2C19 ARE RESPONSIBLE FOR THE IN VITRO N-DEMETHYLATION OF MEPERIDINE IN HUMAN LIVER MICROSOMES

Jacqueline Ramírez, Federico Innocenti, Erin G. Schuetz, David A. Flockhart, Mary V. Relling, Raymond Santucci and Mark J. Ratain
Drug Metabolism and Disposition September 1, 2004, 32 (9) 930-936;
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