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Article CommentaryCommentary

THE ROLES OF TRANSPORTERS AND ENZYMES IN HEPATIC DRUG PROCESSING

Lichuan Liu and K. Sandy Pang
Drug Metabolism and Disposition January 2005, 33 (1) 1-9; DOI: https://doi.org/10.1124/dmd.104.001149
Lichuan Liu
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K. Sandy Pang
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Article Information

vol. 33 no. 1 1-9
DOI 
https://doi.org/10.1124/dmd.104.001149
PubMed 
15466164

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 21, 2004
  • Accepted September 28, 2004
  • Published online December 17, 2004.

Article Versions

  • Earlier version (October 1, 2004 - 10:50).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Lichuan Liu and
  2. K. Sandy Pang
  1. Department of Pharmaceutical Sciences, Faculty of Pharmacy (L.L., K.S.P.), and Department of Pharmacology, Faculty of Medicine (K.S.P.), University of Toronto, Toronto, Ontario, Canada
  1. Address correspondence to:
    Dr. K. S. Pang, Faculty of Pharmacy, University of Toronto, 19 Russell Street, Toronto, ON, Canada M5S 3G2. E-mail: ks.pang{at}utoronto.ca
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Drug Metabolism and Disposition: 33 (1)
Drug Metabolism and Disposition
Vol. 33, Issue 1
1 Jan 2005
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Article CommentaryCommentary

THE ROLES OF TRANSPORTERS AND ENZYMES IN HEPATIC DRUG PROCESSING

Lichuan Liu and K. Sandy Pang
Drug Metabolism and Disposition January 1, 2005, 33 (1) 1-9; DOI: https://doi.org/10.1124/dmd.104.001149

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Article CommentaryCommentary

THE ROLES OF TRANSPORTERS AND ENZYMES IN HEPATIC DRUG PROCESSING

Lichuan Liu and K. Sandy Pang
Drug Metabolism and Disposition January 1, 2005, 33 (1) 1-9; DOI: https://doi.org/10.1124/dmd.104.001149
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  • Article
    • Abstract
    • Theory
    • Improved CLefflux, CLint,sec, and CLint,met Estimates for Physiological Modeling
    • Dynamics of Secretory and Metabolic Intrinsic Clearances and Basolateral Influx and Efflux Clearances on Hepatic Metabolic and Excretory Clearances
    • Liver Tissue Concentration Profiles
    • Effects of the Secretion, the Influx and Efflux Clearances, and Saturable Metabolism on Hepatic Clearance and Metabolite Formation
    • Literature Reports
    • Concluding Remarks
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