Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Research ArticleArticle

BISPHENOL A GLUCURONIDATION AND EXCRETION IN LIVER OF PREGNANT AND NONPREGNANT FEMALE RATS

Hiroki Inoue, Akio Tsuruta, Satoko Kudo, Takako Ishii, Yusuke Fukushima, Hidetomo Iwano, Hiroshi Yokota and Seiyu Kato
Drug Metabolism and Disposition January 2005, 33 (1) 55-59; DOI: https://doi.org/10.1124/dmd.104.001537
Hiroki Inoue
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Akio Tsuruta
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Satoko Kudo
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Takako Ishii
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yusuke Fukushima
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hidetomo Iwano
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hiroshi Yokota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Seiyu Kato
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

In male rats challenged with the environmental estrogen bisphenol A, the compound is highly glucuronidated in the liver and is excreted largely into the bile. Given that in pregnancy the microsomal glucuronidation toward bisphenol A is attenuated, we hypothesized that elimination of bisphenol A from the liver may be reduced in pregnancy. This study was conducted to trace the elimination of bisphenol A in female rats, especially in pregnancy. In Sprague-Dawley rats, 1.5 μmol of bisphenol A was perfused into the liver via the portal vein. In both the male and the nonpregnant female, the infused bisphenol A was glucuronidated, then the resultant glucuronide was excreted mainly into the bile. In pregnant rats, however, bilious excretion of bisphenol A glucuronide was 60% of that observed in nonpregnant rats, and venous excretion increased reciprocally. During 1-h perfusion, total excretion of the glucuronide from the liver of male, nonpregnant female, and pregnant rats was 889.5 ± 69.6, 1256.7 ± 54.8, and 1038.8 ± 33.3 nmoles, respectively. In Eisai hyperbilirubinemic rats (EHBR), perfusion of the liver with bisphenol A enabled us to determine that multidrug resistance-associated protein (MRP)2-mediating transport is the mechanism behind excretion of the glucuronide into the bile. The expression of MRP2 has been reported to be noticeably reduced in pregnancy. These results suggest that bisphenol A elimination by hepatic glucuronidation is slightly less in pregnancy than in non-pregnancy and that in pregnancy, more bisphenol A glucuronide is eliminated to the vein because of reduced MRP2 expression.

Footnotes

  • This work was partially supported by Northern Advancement Center for Science and Technology and by a Grant-in-Aid to Cooperative Research from Rakuno Gakuen University.

  • doi:10.1124/dmd.104.001537.

  • ABBREVIATIONS: bisphenol A, 2,2-bis[4-hydroxyphenyl]propane; MRP, multidrug resistance-associated protein; HPLC, high performance liquid chromatograph; HPLC, high performance liquid chromatography; EHBR, Eisai hyperbilirubinemic rat; UGT, UDP-glucuronosyltransferase.

    • Received July 20, 2004.
    • Accepted October 1, 2004.
  • The American Society for Pharmacology and Experimental Therapeutics
View Full Text

 

DMD articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 33 (1)
Drug Metabolism and Disposition
Vol. 33, Issue 1
1 Jan 2005
  • Table of Contents
  • About the Cover
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
BISPHENOL A GLUCURONIDATION AND EXCRETION IN LIVER OF PREGNANT AND NONPREGNANT FEMALE RATS
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

BISPHENOL A GLUCURONIDATION AND EXCRETION IN LIVER OF PREGNANT AND NONPREGNANT FEMALE RATS

Hiroki Inoue, Akio Tsuruta, Satoko Kudo, Takako Ishii, Yusuke Fukushima, Hidetomo Iwano, Hiroshi Yokota and Seiyu Kato
Drug Metabolism and Disposition January 1, 2005, 33 (1) 55-59; DOI: https://doi.org/10.1124/dmd.104.001537

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

BISPHENOL A GLUCURONIDATION AND EXCRETION IN LIVER OF PREGNANT AND NONPREGNANT FEMALE RATS

Hiroki Inoue, Akio Tsuruta, Satoko Kudo, Takako Ishii, Yusuke Fukushima, Hidetomo Iwano, Hiroshi Yokota and Seiyu Kato
Drug Metabolism and Disposition January 1, 2005, 33 (1) 55-59; DOI: https://doi.org/10.1124/dmd.104.001537
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Warfarin PBPK Model with TMDD Mechanism
  • Identification of payload-containing catabolites of ADCs
  • PK Interactions of Licorice with Cytochrome P450s
Show more Articles

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics