Drug Metabolism and Disposition: 33 (10)

October 01, 2005; Volume 33,Issue 10

Commentary

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SEEING THROUGH THE MIST: ABUNDANCE VERSUS PERCENTAGE. COMMENTARY ON METABOLITES IN SAFETY TESTING
Dennis A. Smith and R. Scott Obach

Drug Metabolism and Disposition October 2005, 33 (10) 1409-1417; DOI: https://doi.org/10.1124/dmd.105.005041

Short Communications

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FUNCTIONAL EXPRESSION OF SINUSOIDAL DRUG TRANSPORTERS IN PRIMARY HUMAN AND RAT HEPATOCYTES
Emilie Jigorel, Marc Le Vee, Claire Boursier-Neyret, Marc Bertrand and Olivier Fardel

Drug Metabolism and Disposition October 2005, 33 (10) 1418-1422; DOI: https://doi.org/10.1124/dmd.105.004762
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EXPRESSION OF CYTOCHROME P450 AND OTHER BIOTRANSFORMATION GENES IN FETAL AND ADULT HUMAN NASAL MUCOSA
Xiuling Zhang, Qing-Yu Zhang, Dazhi Liu, Ting Su, Yan Weng, Guoyu Ling, Ying Chen, Jun Gu, Boris Schilling and Xinxin Ding

Drug Metabolism and Disposition October 2005, 33 (10) 1423-1428; DOI: https://doi.org/10.1124/dmd.105.005769

Articles

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PULMONARY BIOACTIVATION OF TRICHLOROETHYLENE TO CHLORAL HYDRATE: RELATIVE CONTRIBUTIONS OF CYP2E1, CYP2F, AND CYP2B1
Poh-Gek Forkert, R. Michael Baldwin, Brandie Millen, Lawrence H. Lash, David A. Putt, Michael A. Shultz and Kathy S. Collins

Drug Metabolism and Disposition October 2005, 33 (10) 1429-1437; DOI: https://doi.org/10.1124/dmd.105.005074
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A SIMPLE SEQUENTIAL INCUBATION METHOD FOR DECONVOLUTING THE COMPLICATED SEQUENTIAL METABOLISM OF CAPRAVIRINE IN HUMANS
Hai-Zhi Bu, Ping Kang, Ping Zhao, William F. Pool and Ellen Y. Wu

Drug Metabolism and Disposition October 2005, 33 (10) 1438-1445; DOI: https://doi.org/10.1124/dmd.105.005413
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OXIDATION OF TAMOXIFEN BY HUMAN FLAVIN-CONTAINING MONOOXYGENASE (FMO) 1 AND FMO3 TO TAMOXIFEN-N-OXIDE AND ITS NOVEL REDUCTION BACK TO TAMOXIFEN BY HUMAN CYTOCHROMES P450 AND HEMOGLOBIN
Priyanka Parte and David Kupfer

Drug Metabolism and Disposition October 2005, 33 (10) 1446-1452; DOI: https://doi.org/10.1124/dmd.104.000802
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GLUTATHIONE TRAPPING TO MEASURE MICROSOMAL OXIDATION OF FURAN TO CIS-2-BUTENE-1,4-DIAL
Lisa A. Peterson, Meredith E. Cummings, Choua C. Vu and Brock A. Matter

Drug Metabolism and Disposition October 2005, 33 (10) 1453-1458; DOI: https://doi.org/10.1124/dmd.105.004432
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METABOLISM OF PIGMENT YELLOW 74 BY RAT AND HUMAN MICROSOMAL PROTEINS
Yanyan Cui, Mona I. Churchwell, Letha H. Couch, Daniel R. Doerge and Paul C. Howard

Drug Metabolism and Disposition October 2005, 33 (10) 1459-1465; DOI: https://doi.org/10.1124/dmd.104.003285
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UDP-GLUCURONOSYLTRANSFERASE ISOFORMS CATALYZING GLUCURONIDATION OF HYDROXY-POLYCHLORINATED BIPHENYLS IN RAT
Tomo Daidoji, Keisuke Gozu, Hidetomo Iwano, Hiroki Inoue and Hiroshi Yokota

Drug Metabolism and Disposition October 2005, 33 (10) 1466-1476; DOI: https://doi.org/10.1124/dmd.105.004416
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CONTRIBUTION OF OATP (ORGANIC ANION-TRANSPORTING POLYPEPTIDE) FAMILY TRANSPORTERS TO THE HEPATIC UPTAKE OF FEXOFENADINE IN HUMANS
Maki Shimizu, Kaori Fuse, Kazuho Okudaira, Ryuichiro Nishigaki, Kazuya Maeda, Hiroyuki Kusuhara and Yuichi Sugiyama

Drug Metabolism and Disposition October 2005, 33 (10) 1477-1481; DOI: https://doi.org/10.1124/dmd.105.004622
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FUNCTIONAL CHARACTERIZATION OF THREE NATURALLY OCCURRING SINGLE NUCLEOTIDE POLYMORPHISMS IN THE CES2 GENE ENCODING CARBOXYLESTERASE 2 (HCE-2)
Takashi Kubo, Su-Ryang Kim, Kimie Sai, Yoshiro Saito, Toshiharu Nakajima, Kenji Matsumoto, Hirohisa Saito, Kuniaki Shirao, Noboru Yamamoto, Hironobu Minami, Atsushi Ohtsu, Teruhiko Yoshida, Nagahiro Saijo, Yasuo Ohno, Shogo Ozawa and Jun-ichi Sawada

Drug Metabolism and Disposition October 2005, 33 (10) 1482-1487; DOI: https://doi.org/10.1124/dmd.105.005587
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PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR PRALMORELIN HYDROCHLORIDE IN RATS
Risa Nasu, Yoichi Kumagai, Hirokuni Kogetsu, Masayuki Tsujimoto, Hisakazu Ohtani and Yasufumi Sawada

Drug Metabolism and Disposition October 2005, 33 (10) 1488-1494; DOI: https://doi.org/10.1124/dmd.104.001040
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HUMAN CYP2D6 AND MOUSE CYP2DS: ORGAN DISTRIBUTION IN A HUMANIZED MOUSE MODEL
Sharon L. Miksys, Connie Cheung, Frank J. Gonzalez and Rachel F. Tyndale

Drug Metabolism and Disposition October 2005, 33 (10) 1495-1502; DOI: https://doi.org/10.1124/dmd.105.005488
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METABOLISM AND DISPOSITION OF IMATINIB MESYLATE IN HEALTHY VOLUNTEERS
Hans-Peter Gschwind, Ulrike Pfaar, Felix Waldmeier, Markus Zollinger, Claudia Sayer, Peter Zbinden, Michael Hayes, Rolf Pokorny, Michael Seiberling, Monique Ben-Am, Bin Peng and Gerhard Gross

Drug Metabolism and Disposition October 2005, 33 (10) 1503-1512; DOI: https://doi.org/10.1124/dmd.105.004283
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AN INVESTIGATION OF HUMAN AND RAT LIVER MICROSOMAL MYCOPHENOLIC ACID GLUCURONIDATION: EVIDENCE FOR A PRINCIPAL ROLE OF UGT1A ENZYMES AND SPECIES DIFFERENCES IN UGT1A SPECIFICITY
Kristini K. Miles, Stephan T. Stern, Philip C. Smith, Fay K. Kessler, Shazia Ali and Joseph K. Ritter

Drug Metabolism and Disposition October 2005, 33 (10) 1513-1520; DOI: https://doi.org/10.1124/dmd.105.004663
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THE SIGNAL TRANSDUCTION PATHWAYS INVOLVED IN HEPATIC CYTOCHROME P450 REGULATION IN THE RAT DURING A LIPOPOLYSACCHARIDE-INDUCED MODEL OF CENTRAL NERVOUS SYSTEM INFLAMMATION
Dalya Abdulla, Kerry B. Goralski, Elena Garcia Del Busto Cano and Kenneth W. Renton

Drug Metabolism and Disposition October 2005, 33 (10) 1521-1531; DOI: https://doi.org/10.1124/dmd.105.004564
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METABOLISM OF N-HYDROXYGUANIDINES (N-HYDROXYDEBRISOQUINE) IN HUMAN AND PORCINE HEPATOCYTES: REDUCTION AND FORMATION OF GLUCURONIDES
Anja Kristina Froehlich, Ulrich Girreser and Bernd Clement

Drug Metabolism and Disposition October 2005, 33 (10) 1532-1537; DOI: https://doi.org/10.1124/dmd.105.004572
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PHARMACOKINETICS AND METABOLISM OF A NEW POTENT ANTIEPILEPTIC DRUG, 2,2,3,3-TETRAMETHYCYCLOPROPANECARBONYLUREA, IN RATS
Eyal Sobol, Boris Yagen, Ilan Winkler, Malka Britzi, Dan Gibson and Meir Bialer

Drug Metabolism and Disposition October 2005, 33 (10) 1538-1546; DOI: https://doi.org/10.1124/dmd.105.005637
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THE BLOOD-BRAIN BARRIER SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER: A MOLECULAR FUNCTIONAL IN VITRO-IN SITU CORRELATION
Seonghee Park and Patrick J. Sinko

Drug Metabolism and Disposition October 2005, 33 (10) 1547-1554; DOI: https://doi.org/10.1124/dmd.105.005231
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PHARMACOKINETICS AND DISPOSITION OF THE KAVALACTONE KAWAIN: INTERACTION WITH KAVA EXTRACT AND KAVALACTONES IN VIVO AND IN VITRO
James M. Mathews, Amy S. Etheridge, John L. Valentine, Sherry R. Black, Donna P. Coleman, Purvi Patel, James So and Leo T. Burka

Drug Metabolism and Disposition October 2005, 33 (10) 1555-1563; DOI: https://doi.org/10.1124/dmd.105.004317

Letters to the Editor

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COMMENT ON “A FRAMESHIFT MUTATION AND ALTERNATE SPLICING IN HUMAN BRAIN GENERATE A FUNCTIONAL FORM OF THE PSEUDOGENE CYTOCHROME P4502D7 THAT DEMETHYLATES CODEINE TO MORPHINE”
Janelle M. Hoskins, Sharon Marsh and Howard L. McLeod

Drug Metabolism and Disposition October 2005, 33 (10) 1564-1565; DOI: https://doi.org/10.1124/dmd.105.005736
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RESPONSE TO COMMENT ON “A FRAMESHIFT MUTATION AND ALTERNATE SPLICING IN HUMAN BRAIN GENERATE A FUNCTIONAL FORM OF THE PSEUDOGENE CYTOCHROME P4502D7 THAT DEMETHYLATES CODEINE TO MORPHINE”
Harish V. Pai and Vijayalakshmi Ravindranath

Drug Metabolism and Disposition October 2005, 33 (10) 1566; DOI: https://doi.org/10.1124/dmd.105.006155

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