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Drug Metabolism & Disposition

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Table of Contents

October 01, 2005; Volume 33,Issue 10

Commentary

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    SEEING THROUGH THE MIST: ABUNDANCE VERSUS PERCENTAGE. COMMENTARY ON METABOLITES IN SAFETY TESTING
    Dennis A. Smith and R. Scott Obach
    Drug Metabolism and Disposition October 2005, 33 (10) 1409-1417; DOI: https://doi.org/10.1124/dmd.105.005041

Short Communications

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    FUNCTIONAL EXPRESSION OF SINUSOIDAL DRUG TRANSPORTERS IN PRIMARY HUMAN AND RAT HEPATOCYTES
    Emilie Jigorel, Marc Le Vee, Claire Boursier-Neyret, Marc Bertrand and Olivier Fardel
    Drug Metabolism and Disposition October 2005, 33 (10) 1418-1422; DOI: https://doi.org/10.1124/dmd.105.004762
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    EXPRESSION OF CYTOCHROME P450 AND OTHER BIOTRANSFORMATION GENES IN FETAL AND ADULT HUMAN NASAL MUCOSA
    Xiuling Zhang, Qing-Yu Zhang, Dazhi Liu, Ting Su, Yan Weng, Guoyu Ling, Ying Chen, Jun Gu, Boris Schilling and Xinxin Ding
    Drug Metabolism and Disposition October 2005, 33 (10) 1423-1428; DOI: https://doi.org/10.1124/dmd.105.005769

Articles

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    PULMONARY BIOACTIVATION OF TRICHLOROETHYLENE TO CHLORAL HYDRATE: RELATIVE CONTRIBUTIONS OF CYP2E1, CYP2F, AND CYP2B1
    Poh-Gek Forkert, R. Michael Baldwin, Brandie Millen, Lawrence H. Lash, David A. Putt, Michael A. Shultz and Kathy S. Collins
    Drug Metabolism and Disposition October 2005, 33 (10) 1429-1437; DOI: https://doi.org/10.1124/dmd.105.005074
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    A SIMPLE SEQUENTIAL INCUBATION METHOD FOR DECONVOLUTING THE COMPLICATED SEQUENTIAL METABOLISM OF CAPRAVIRINE IN HUMANS
    Hai-Zhi Bu, Ping Kang, Ping Zhao, William F. Pool and Ellen Y. Wu
    Drug Metabolism and Disposition October 2005, 33 (10) 1438-1445; DOI: https://doi.org/10.1124/dmd.105.005413
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    OXIDATION OF TAMOXIFEN BY HUMAN FLAVIN-CONTAINING MONOOXYGENASE (FMO) 1 AND FMO3 TO TAMOXIFEN-N-OXIDE AND ITS NOVEL REDUCTION BACK TO TAMOXIFEN BY HUMAN CYTOCHROMES P450 AND HEMOGLOBIN
    Priyanka Parte and David Kupfer
    Drug Metabolism and Disposition October 2005, 33 (10) 1446-1452; DOI: https://doi.org/10.1124/dmd.104.000802
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    GLUTATHIONE TRAPPING TO MEASURE MICROSOMAL OXIDATION OF FURAN TO CIS-2-BUTENE-1,4-DIAL
    Lisa A. Peterson, Meredith E. Cummings, Choua C. Vu and Brock A. Matter
    Drug Metabolism and Disposition October 2005, 33 (10) 1453-1458; DOI: https://doi.org/10.1124/dmd.105.004432
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    METABOLISM OF PIGMENT YELLOW 74 BY RAT AND HUMAN MICROSOMAL PROTEINS
    Yanyan Cui, Mona I. Churchwell, Letha H. Couch, Daniel R. Doerge and Paul C. Howard
    Drug Metabolism and Disposition October 2005, 33 (10) 1459-1465; DOI: https://doi.org/10.1124/dmd.104.003285
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    UDP-GLUCURONOSYLTRANSFERASE ISOFORMS CATALYZING GLUCURONIDATION OF HYDROXY-POLYCHLORINATED BIPHENYLS IN RAT
    Tomo Daidoji, Keisuke Gozu, Hidetomo Iwano, Hiroki Inoue and Hiroshi Yokota
    Drug Metabolism and Disposition October 2005, 33 (10) 1466-1476; DOI: https://doi.org/10.1124/dmd.105.004416
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    CONTRIBUTION OF OATP (ORGANIC ANION-TRANSPORTING POLYPEPTIDE) FAMILY TRANSPORTERS TO THE HEPATIC UPTAKE OF FEXOFENADINE IN HUMANS
    Maki Shimizu, Kaori Fuse, Kazuho Okudaira, Ryuichiro Nishigaki, Kazuya Maeda, Hiroyuki Kusuhara and Yuichi Sugiyama
    Drug Metabolism and Disposition October 2005, 33 (10) 1477-1481; DOI: https://doi.org/10.1124/dmd.105.004622
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    FUNCTIONAL CHARACTERIZATION OF THREE NATURALLY OCCURRING SINGLE NUCLEOTIDE POLYMORPHISMS IN THE CES2 GENE ENCODING CARBOXYLESTERASE 2 (HCE-2)
    Takashi Kubo, Su-Ryang Kim, Kimie Sai, Yoshiro Saito, Toshiharu Nakajima, Kenji Matsumoto, Hirohisa Saito, Kuniaki Shirao, Noboru Yamamoto, Hironobu Minami, Atsushi Ohtsu, Teruhiko Yoshida, Nagahiro Saijo, Yasuo Ohno, Shogo Ozawa and Jun-ichi Sawada
    Drug Metabolism and Disposition October 2005, 33 (10) 1482-1487; DOI: https://doi.org/10.1124/dmd.105.005587
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    PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR PRALMORELIN HYDROCHLORIDE IN RATS
    Risa Nasu, Yoichi Kumagai, Hirokuni Kogetsu, Masayuki Tsujimoto, Hisakazu Ohtani and Yasufumi Sawada
    Drug Metabolism and Disposition October 2005, 33 (10) 1488-1494; DOI: https://doi.org/10.1124/dmd.104.001040
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    HUMAN CYP2D6 AND MOUSE CYP2DS: ORGAN DISTRIBUTION IN A HUMANIZED MOUSE MODEL
    Sharon L. Miksys, Connie Cheung, Frank J. Gonzalez and Rachel F. Tyndale
    Drug Metabolism and Disposition October 2005, 33 (10) 1495-1502; DOI: https://doi.org/10.1124/dmd.105.005488
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    METABOLISM AND DISPOSITION OF IMATINIB MESYLATE IN HEALTHY VOLUNTEERS
    Hans-Peter Gschwind, Ulrike Pfaar, Felix Waldmeier, Markus Zollinger, Claudia Sayer, Peter Zbinden, Michael Hayes, Rolf Pokorny, Michael Seiberling, Monique Ben-Am, Bin Peng and Gerhard Gross
    Drug Metabolism and Disposition October 2005, 33 (10) 1503-1512; DOI: https://doi.org/10.1124/dmd.105.004283
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    AN INVESTIGATION OF HUMAN AND RAT LIVER MICROSOMAL MYCOPHENOLIC ACID GLUCURONIDATION: EVIDENCE FOR A PRINCIPAL ROLE OF UGT1A ENZYMES AND SPECIES DIFFERENCES IN UGT1A SPECIFICITY
    Kristini K. Miles, Stephan T. Stern, Philip C. Smith, Fay K. Kessler, Shazia Ali and Joseph K. Ritter
    Drug Metabolism and Disposition October 2005, 33 (10) 1513-1520; DOI: https://doi.org/10.1124/dmd.105.004663
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    THE SIGNAL TRANSDUCTION PATHWAYS INVOLVED IN HEPATIC CYTOCHROME P450 REGULATION IN THE RAT DURING A LIPOPOLYSACCHARIDE-INDUCED MODEL OF CENTRAL NERVOUS SYSTEM INFLAMMATION
    Dalya Abdulla, Kerry B. Goralski, Elena Garcia Del Busto Cano and Kenneth W. Renton
    Drug Metabolism and Disposition October 2005, 33 (10) 1521-1531; DOI: https://doi.org/10.1124/dmd.105.004564
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    METABOLISM OF N-HYDROXYGUANIDINES (N-HYDROXYDEBRISOQUINE) IN HUMAN AND PORCINE HEPATOCYTES: REDUCTION AND FORMATION OF GLUCURONIDES
    Anja Kristina Froehlich, Ulrich Girreser and Bernd Clement
    Drug Metabolism and Disposition October 2005, 33 (10) 1532-1537; DOI: https://doi.org/10.1124/dmd.105.004572
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    PHARMACOKINETICS AND METABOLISM OF A NEW POTENT ANTIEPILEPTIC DRUG, 2,2,3,3-TETRAMETHYCYCLOPROPANECARBONYLUREA, IN RATS
    Eyal Sobol, Boris Yagen, Ilan Winkler, Malka Britzi, Dan Gibson and Meir Bialer
    Drug Metabolism and Disposition October 2005, 33 (10) 1538-1546; DOI: https://doi.org/10.1124/dmd.105.005637
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    THE BLOOD-BRAIN BARRIER SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER: A MOLECULAR FUNCTIONAL IN VITRO-IN SITU CORRELATION
    Seonghee Park and Patrick J. Sinko
    Drug Metabolism and Disposition October 2005, 33 (10) 1547-1554; DOI: https://doi.org/10.1124/dmd.105.005231
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    PHARMACOKINETICS AND DISPOSITION OF THE KAVALACTONE KAWAIN: INTERACTION WITH KAVA EXTRACT AND KAVALACTONES IN VIVO AND IN VITRO
    James M. Mathews, Amy S. Etheridge, John L. Valentine, Sherry R. Black, Donna P. Coleman, Purvi Patel, James So and Leo T. Burka
    Drug Metabolism and Disposition October 2005, 33 (10) 1555-1563; DOI: https://doi.org/10.1124/dmd.105.004317

Letters to the Editor

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    COMMENT ON “A FRAMESHIFT MUTATION AND ALTERNATE SPLICING IN HUMAN BRAIN GENERATE A FUNCTIONAL FORM OF THE PSEUDOGENE CYTOCHROME P4502D7 THAT DEMETHYLATES CODEINE TO MORPHINE”
    Janelle M. Hoskins, Sharon Marsh and Howard L. McLeod
    Drug Metabolism and Disposition October 2005, 33 (10) 1564-1565; DOI: https://doi.org/10.1124/dmd.105.005736
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    RESPONSE TO COMMENT ON “A FRAMESHIFT MUTATION AND ALTERNATE SPLICING IN HUMAN BRAIN GENERATE A FUNCTIONAL FORM OF THE PSEUDOGENE CYTOCHROME P4502D7 THAT DEMETHYLATES CODEINE TO MORPHINE”
    Harish V. Pai and Vijayalakshmi Ravindranath
    Drug Metabolism and Disposition October 2005, 33 (10) 1566; DOI: https://doi.org/10.1124/dmd.105.006155
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Drug Metabolism and Disposition: 33 (10)
Drug Metabolism and Disposition
Vol. 33, Issue 10
1 Oct 2005
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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