Table of Contents

Articles

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  PULMONARY BIOACTIVATION OF TRICHLOROETHYLENE TO CHLORAL HYDRATE: RELATIVE CONTRIBUTIONS OF CYP2E1, CYP2F, AND CYP2B1

  Poh-Gek Forkert, R. Michael Baldwin, Brandie Millen, Lawrence H. Lash, David A. Putt, Michael A. Shultz and Kathy S. Collins

  Drug Metabolism and Disposition October 2005, 33 (10) 1429-1437; DOI: https://doi.org/10.1124/dmd.105.005074
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  A SIMPLE SEQUENTIAL INCUBATION METHOD FOR DECONVOLUTING THE COMPLICATED SEQUENTIAL METABOLISM OF CAPRAVIRINE IN HUMANS

  Hai-Zhi Bu, Ping Kang, Ping Zhao, William F. Pool and Ellen Y. Wu

  Drug Metabolism and Disposition October 2005, 33 (10) 1438-1445; DOI: https://doi.org/10.1124/dmd.105.005413
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  OXIDATION OF TAMOXIFEN BY HUMAN FLAVIN-CONTAINING MONOOXYGENASE (FMO) 1 AND FMO3 TO TAMOXIFEN-N-OXIDE AND ITS NOVEL REDUCTION BACK TO TAMOXIFEN BY HUMAN CYTOCHROMES P450 AND HEMOGLOBIN

  Priyanka Parte and David Kupfer

  Drug Metabolism and Disposition October 2005, 33 (10) 1446-1452; DOI: https://doi.org/10.1124/dmd.104.000802
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  GLUTATHIONE TRAPPING TO MEASURE MICROSOMAL OXIDATION OF FURAN TO CIS-2-BUTENE-1,4-DIAL

  Lisa A. Peterson, Meredith E. Cummings, Choua C. Vu and Brock A. Matter

  Drug Metabolism and Disposition October 2005, 33 (10) 1453-1458; DOI: https://doi.org/10.1124/dmd.105.004432
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  METABOLISM OF PIGMENT YELLOW 74 BY RAT AND HUMAN MICROSOMAL PROTEINS

  Yanyan Cui, Mona I. Churchwell, Letha H. Couch, Daniel R. Doerge and Paul C. Howard

  Drug Metabolism and Disposition October 2005, 33 (10) 1459-1465; DOI: https://doi.org/10.1124/dmd.104.003285
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  UDP-GLUCURONOSYLTRANSFERASE ISOFORMS CATALYZING GLUCURONIDATION OF HYDROXY-POLYCHLORINATED BIPHENYLS IN RAT

  Tomo Daidoji, Keisuke Gozu, Hidetomo Iwano, Hiroki Inoue and Hiroshi Yokota

  Drug Metabolism and Disposition October 2005, 33 (10) 1466-1476; DOI: https://doi.org/10.1124/dmd.105.004416
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  CONTRIBUTION OF OATP (ORGANIC ANION-TRANSPORTING POLYPEPTIDE) FAMILY TRANSPORTERS TO THE HEPATIC UPTAKE OF FEXOFENADINE IN HUMANS

  Maki Shimizu, Kaori Fuse, Kazuho Okudaira, Ryuichiro Nishigaki, Kazuya Maeda, Hiroyuki Kusuhara and Yuichi Sugiyama

  Drug Metabolism and Disposition October 2005, 33 (10) 1477-1481; DOI: https://doi.org/10.1124/dmd.105.004622
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  FUNCTIONAL CHARACTERIZATION OF THREE NATURALLY OCCURRING SINGLE NUCLEOTIDE POLYMORPHISMS IN THE CES2 GENE ENCODING CARBOXYLESTERASE 2 (HCE-2)

  Takashi Kubo, Su-Ryang Kim, Kimie Sai, Yoshiro Saito, Toshiharu Nakajima, Kenji Matsumoto, Hirohisa Saito, Kuniaki Shirao, Noboru Yamamoto, Hironobu Minami, Atsushi Ohtsu, Teruhiko Yoshida, Nagahiro Saijo, Yasuo Ohno, Shogo Ozawa and Jun-ichi Sawada

  Drug Metabolism and Disposition October 2005, 33 (10) 1482-1487; DOI: https://doi.org/10.1124/dmd.105.005587
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  PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR PRALMORELIN HYDROCHLORIDE IN RATS

  Risa Nasu, Yoichi Kumagai, Hirokuni Kogetsu, Masayuki Tsujimoto, Hisakazu Ohtani and Yasufumi Sawada

  Drug Metabolism and Disposition October 2005, 33 (10) 1488-1494; DOI: https://doi.org/10.1124/dmd.104.001040
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  HUMAN CYP2D6 AND MOUSE CYP2DS: ORGAN DISTRIBUTION IN A HUMANIZED MOUSE MODEL

  Sharon L. Miksys, Connie Cheung, Frank J. Gonzalez and Rachel F. Tyndale

  Drug Metabolism and Disposition October 2005, 33 (10) 1495-1502; DOI: https://doi.org/10.1124/dmd.105.005488
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  METABOLISM AND DISPOSITION OF IMATINIB MESYLATE IN HEALTHY VOLUNTEERS

  Hans-Peter Gschwind, Ulrike Pfaar, Felix Waldmeier, Markus Zollinger, Claudia Sayer, Peter Zbinden, Michael Hayes, Rolf Pokorny, Michael Seiberling, Monique Ben-Am, Bin Peng and Gerhard Gross

  Drug Metabolism and Disposition October 2005, 33 (10) 1503-1512; DOI: https://doi.org/10.1124/dmd.105.004283
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  AN INVESTIGATION OF HUMAN AND RAT LIVER MICROSOMAL MYCOPHENOLIC ACID GLUCURONIDATION: EVIDENCE FOR A PRINCIPAL ROLE OF UGT1A ENZYMES AND SPECIES DIFFERENCES IN UGT1A SPECIFICITY

  Kristini K. Miles, Stephan T. Stern, Philip C. Smith, Fay K. Kessler, Shazia Ali and Joseph K. Ritter

  Drug Metabolism and Disposition October 2005, 33 (10) 1513-1520; DOI: https://doi.org/10.1124/dmd.105.004663
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  THE SIGNAL TRANSDUCTION PATHWAYS INVOLVED IN HEPATIC CYTOCHROME P450 REGULATION IN THE RAT DURING A LIPOPOLYSACCHARIDE-INDUCED MODEL OF CENTRAL NERVOUS SYSTEM INFLAMMATION

  Dalya Abdulla, Kerry B. Goralski, Elena Garcia Del Busto Cano and Kenneth W. Renton

  Drug Metabolism and Disposition October 2005, 33 (10) 1521-1531; DOI: https://doi.org/10.1124/dmd.105.004564
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  METABOLISM OF N-HYDROXYGUANIDINES (N-HYDROXYDEBRISOQUINE) IN HUMAN AND PORCINE HEPATOCYTES: REDUCTION AND FORMATION OF GLUCURONIDES

  Anja Kristina Froehlich, Ulrich Girreser and Bernd Clement

  Drug Metabolism and Disposition October 2005, 33 (10) 1532-1537; DOI: https://doi.org/10.1124/dmd.105.004572
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  PHARMACOKINETICS AND METABOLISM OF A NEW POTENT ANTIEPILEPTIC DRUG, 2,2,3,3-TETRAMETHYCYCLOPROPANECARBONYLUREA, IN RATS

  Eyal Sobol, Boris Yagen, Ilan Winkler, Malka Britzi, Dan Gibson and Meir Bialer

  Drug Metabolism and Disposition October 2005, 33 (10) 1538-1546; DOI: https://doi.org/10.1124/dmd.105.005637
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  THE BLOOD-BRAIN BARRIER SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER: A MOLECULAR FUNCTIONAL IN VITRO-IN SITU CORRELATION

  Seonghee Park and Patrick J. Sinko

  Drug Metabolism and Disposition October 2005, 33 (10) 1547-1554; DOI: https://doi.org/10.1124/dmd.105.005231
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  PHARMACOKINETICS AND DISPOSITION OF THE KAVALACTONE KAWAIN: INTERACTION WITH KAVA EXTRACT AND KAVALACTONES IN VIVO AND IN VITRO

  James M. Mathews, Amy S. Etheridge, John L. Valentine, Sherry R. Black, Donna P. Coleman, Purvi Patel, James So and Leo T. Burka

  Drug Metabolism and Disposition October 2005, 33 (10) 1555-1563; DOI: https://doi.org/10.1124/dmd.105.004317