Drug Metabolism and Disposition: 33 (11)

November 01, 2005; Volume 33,Issue 11

Commentary

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IMPACT OF CYP2C9 GENOTYPE ON PHARMACOKINETICS: ARE ALL CYCLOOXYGENASE INHIBITORS THE SAME?
A. David Rodrigues

Drug Metabolism and Disposition November 2005, 33 (11) 1567-1575; DOI: https://doi.org/10.1124/dmd.105.006452

Short Communications

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INTERACTION OF PROGESTINS WITH THE HUMAN MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2 (MRP2)
Heike Lindenmaier, Melanie Becker, Walter Emil Haefeli and Johanna Weiss

Drug Metabolism and Disposition November 2005, 33 (11) 1576-1579; DOI: https://doi.org/10.1124/dmd.105.005314
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EXTRACTS AND KAVALACTONES OF PIPER METHYSTICUM G. FORST (KAVA-KAVA) INHIBIT P-GLYCOPROTEIN IN VITRO
Johanna Weiss, Alexandra Sauer, Andreas Frank and Matthias Unger

Drug Metabolism and Disposition November 2005, 33 (11) 1580-1583; DOI: https://doi.org/10.1124/dmd.105.005892
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MODULATION OF P-GLYCOPROTEIN EXPRESSION IN HYPERTHYROID RAT TISSUES
Naoki Nishio, Toshiya Katsura, Kayoko Ashida, Masahiro Okuda and Ken-ichi Inui

Drug Metabolism and Disposition November 2005, 33 (11) 1584-1587; DOI: https://doi.org/10.1124/dmd.105.004770
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ANTI-AIDS AGENTS 65: INVESTIGATION OF THE IN VITRO OXIDATIVE METABOLISM OF 3′,4′-DI-O-(–)-CAMPHANOYL-(+)-CIS-KHELLACTONE DERIVATIVES AS POTENT ANTI-HIV AGENTS
Madoka Suzuki, Yutai Li, Philip C. Smith, James A. Swenberg, David E. Martin, Susan L. Morris-Natschke and Kuo-Hsiung Lee

Drug Metabolism and Disposition November 2005, 33 (11) 1588-1592; DOI: https://doi.org/10.1124/dmd.105.004218
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DISPOSITION OF ORAL AND INTRAVENOUS PRAVASTATIN IN MRP2-DEFICIENT TR^– RATS
Kari T. Kivistö, Olaf Grisk, Ute Hofmann, Konrad Meissner, Klaus-Uwe Möritz, Christoph Ritter, Katja A. Arnold, Dieter Lutjöohann, Klaus von Bergmann, Ingrid Klöting, Michel Eichelbaum and Heyo K. Kroemer

Drug Metabolism and Disposition November 2005, 33 (11) 1593-1596; DOI: https://doi.org/10.1124/dmd.105.006262
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ESTROUS CYCLE ALTERS NAPHTHALENE METABOLISM IN FEMALE MOUSE AIRWAYS
Rhonda L. Stelck, Gregory L. Baker, Katherine M. Sutherland and Laura S. Van Winkle

Drug Metabolism and Disposition November 2005, 33 (11) 1597-1602; DOI: https://doi.org/10.1124/dmd.105.005124
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LOCALIZATION AND mRNA EXPRESSION OF CYP3A AND P-GLYCOPROTEIN IN HUMAN DUODENUM AS A FUNCTION OF AGE
May Fakhoury, Catherine Litalien, Yves Medard, Hélène Cavé, Nadia Ezzahir, Michel Peuchmaur and Evelyne Jacqz-Aigrain

Drug Metabolism and Disposition November 2005, 33 (11) 1603-1607; DOI: https://doi.org/10.1124/dmd.105.005611

Articles

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DECREASE IN SERUM THYROXINE LEVEL BY PHENOBARBITAL IN RATS IS NOT NECESSARILY DEPENDENT ON INCREASE IN HEPATIC UDP-GLUCURONOSYLTRANSFERASE
Yoshihisa Kato, Hiroshi Suzuki, Shinichi Ikushiro, Shizuo Yamada and Masakuni Degawa

Drug Metabolism and Disposition November 2005, 33 (11) 1608-1612; DOI: https://doi.org/10.1124/dmd.105.005744
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CHARACTERIZATION OF RAT SMALL INTESTINAL AND COLON PRECISION-CUT SLICES AS AN IN VITRO SYSTEM FOR DRUG METABOLISM AND INDUCTION STUDIES
Esther G. van de Kerkhof, Inge A. M. de Graaf, Marina H. de Jager, Dirk K. F. Meijer and Geny M. M. Groothuis

Drug Metabolism and Disposition November 2005, 33 (11) 1613-1620; DOI: https://doi.org/10.1124/dmd.105.005686
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ALTERED AZT (3′-AZIDO-3′-DEOXYTHYMIDINE) GLUCURONIDATION KINETICS IN LIVER MICROSOMES AS AN EXPLANATION FOR UNDERPREDICTION OF IN VIVO CLEARANCE: COMPARISON TO HEPATOCYTES AND EFFECT OF INCUBATION ENVIRONMENT
Juntyma J. Engtrakul, Robert S. Foti, Timothy J. Strelevitz and Michael B. Fisher

Drug Metabolism and Disposition November 2005, 33 (11) 1621-1627; DOI: https://doi.org/10.1124/dmd.105.005058
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IN VITRO METABOLISM OF THE CALMODULIN ANTAGONIST DY-9760e (3-[2-[4-(3-CHLORO-2-METHYLPHENYL)-1-PIPERAZINYL]ETHYL]-5,6-DIMETHOXY-1-(4-IMIDAZOLYLMETHYL)-1H-INDAZOLE DIHYDROCHLORIDE 3.5 HYDRATE) BY HUMAN LIVER MICROSOMES: INVOLVEMENT OF CYTOCHROMES P450 IN ATYPICAL KINETICS AND POTENTIAL DRUG INTERACTIONS
Shuko Tachibana, Yuko Fujimaki, Hiroyuki Yokoyama, Osamu Okazaki and Ken-ichi Sudo

Drug Metabolism and Disposition November 2005, 33 (11) 1628-1636; DOI: https://doi.org/10.1124/dmd.105.004903
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AUTOMATED ASSESSMENT OF TIME-DEPENDENT INHIBITION OF HUMAN CYTOCHROME P450 ENZYMES USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY ANALYSIS
Anthony Atkinson, Jane R. Kenny and Ken Grime

Drug Metabolism and Disposition November 2005, 33 (11) 1637-1647; DOI: https://doi.org/10.1124/dmd.105.005579
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METABOLISM OF MYOSMINE IN WISTAR RATS
Wolfgang Zwickenpflug, Stefan Tyroller and Elmar Richter

Drug Metabolism and Disposition November 2005, 33 (11) 1648-1656; DOI: https://doi.org/10.1124/dmd.104.003087
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IMPORTANCE OF CYP2D3 IN POLYMORPHISM OF DIAZEPAM P-HYDROXYLATION IN RATS
Noriaki Sakai, Konomu Saito, Hyung-Sub Kim, Akio Kazusaka, Mayumi Ishizuka, Yoshihiko Funae and Shoichi Fujita

Drug Metabolism and Disposition November 2005, 33 (11) 1657-1660; DOI: https://doi.org/10.1124/dmd.105.004242
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THE DECREASE IN LEVEL OF SERUM THYROXINE BY 2,2′,4,5,5′-PENTACHLOROBIPHENYL IN RATS AND MICE: NO CORRELATION WITH FORMATION OF METHYLSULFONYL METABOLITES
Yoshihisa Kato, Koichi Haraguchi, Tomoaki Yamazaki, Ryohei Kimura, Nobuyuki Koga, Shizuo Yamada and Masakuni Degawa

Drug Metabolism and Disposition November 2005, 33 (11) 1661-1665; DOI: https://doi.org/10.1124/dmd.105.006189
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FLAVONOIDS AS A NOVEL CLASS OF HUMAN ORGANIC ANION-TRANSPORTING POLYPEPTIDE OATP1B1 (OATP-C) MODULATORS
Xiaodong Wang, Allan W. Wolkoff and Marilyn E. Morris

Drug Metabolism and Disposition November 2005, 33 (11) 1666-1672; DOI: https://doi.org/10.1124/dmd.105.005926
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FORMATION OF TAMOXIFEN-DNA ADDUCTS VIA O-SULFONATION, NOT O-ACETYLATION, OF α-HYDROXYTAMOXIFEN IN RAT AND HUMAN LIVERS
Sung Yeon Kim, Y. R. Santosh Laxmi, Naomi Suzuki, Kenichiro Ogura, Tadashi Watabe, Michael W. Duffel and Shinya Shibutani

Drug Metabolism and Disposition November 2005, 33 (11) 1673-1678; DOI: https://doi.org/10.1124/dmd.105.005330
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FUNCTIONAL ASSESSMENT OF MULTIPLE P-GLYCOPROTEIN (P-GP) PROBE SUBSTRATES: INFLUENCE OF CELL LINE AND MODULATOR CONCENTRATION ON P-GP ACTIVITY
Mitchell E. Taub, Lalitha Podila, Diane Ely and Iliana Almeida

Drug Metabolism and Disposition November 2005, 33 (11) 1679-1687; DOI: https://doi.org/10.1124/dmd.105.005421
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BIOTRANSFORMATION OF A GABA_A RECEPTOR PARTIAL AGONIST IN SPRAGUE-DAWLEY RATS AND CYNOMOLGUS MONKEYS: IDENTIFICATION OF TWO UNIQUE N-CARBAMOYL METABOLITES
Christopher L. Shaffer, Mithat Gunduz, Thomas N. O'Connell, R. Scott Obach and Shiyin Yee

Drug Metabolism and Disposition November 2005, 33 (11) 1688-1699; DOI: https://doi.org/10.1124/dmd.105.004630
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PREDICTION OF CYP2C9-MEDIATED DRUG-DRUG INTERACTIONS: A COMPARISON USING DATA FROM RECOMBINANT ENZYMES AND HUMAN HEPATOCYTES
Dermot F. McGinnity, James Tucker, Steve Trigg and Robert J. Riley

Drug Metabolism and Disposition November 2005, 33 (11) 1700-1707; DOI: https://doi.org/10.1124/dmd.105.005884
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BIOTRANSFORMATION OF DERAMCICLANE IN PRIMARY HEPATOCYTES OF RAT, MOUSE, RABBIT, DOG, AND HUMAN
Katalin Monostory, Krisztina Kőhalmy, Krisztina Ludányi, Gábor Czira, Sándor Holly, László Vereczkey, Iván Ürmös, Imre Klebovich and László Kóbori

Drug Metabolism and Disposition November 2005, 33 (11) 1708-1716; DOI: https://doi.org/10.1124/dmd.105.003764
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ROLE OF CYP2E1 IN DERAMCICLANE METABOLISM
Katalin Monostory, Krisztina Köhalmy, Eszter Hazai, László Vereczkey and László Kóbori

Drug Metabolism and Disposition November 2005, 33 (11) 1717-1722; DOI: https://doi.org/10.1124/dmd.105.003772
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RELATIVE CONTRIBUTIONS OF THE FIVE MAJOR HUMAN CYTOCHROMES P450, 1A2, 2C9, 2C19, 2D6, AND 3A4, TO THE HEPATIC METABOLISM OF THE PROTEASOME INHIBITOR BORTEZOMIB
Vinita Uttamsingh, Chuang Lu, Gerald Miwa and Liang-Shang Gan

Drug Metabolism and Disposition November 2005, 33 (11) 1723-1728; DOI: https://doi.org/10.1124/dmd.105.005710
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IN VITRO INHIBITION OF UDP GLUCURONOSYLTRANSFERASES BY ATAZANAVIR AND OTHER HIV PROTEASE INHIBITORS AND THE RELATIONSHIP OF THIS PROPERTY TO IN VIVO BILIRUBIN GLUCURONIDATION
Donglu Zhang, Theodore J. Chando, Donald W. Everett, Christopher J. Patten, Shangara S. Dehal and W. Griffith Humphreys

Drug Metabolism and Disposition November 2005, 33 (11) 1729-1739; DOI: https://doi.org/10.1124/dmd.105.005447
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HEPATIC, EXTRAHEPATIC, MICROSOMAL, AND MITOCHONDRIAL ACTIVATION OF THE N-HYDROXYLATED PRODRUGS BENZAMIDOXIME, GUANOXABENZ, AND RO 48-3656 ([[1-[(2S)-2-[[4-[(HYDROXYAMINO)IMINOMETHYL]BENZOYL]AMINO]-1-OXOPROPYL]-4-PIPERIDINYL]OXY]-ACETIC ACID)
Bernd Clement, Sabine Mau, Stephanie Deters and Antje Havemeyer

Drug Metabolism and Disposition November 2005, 33 (11) 1740-1747; DOI: https://doi.org/10.1124/dmd.105.005249
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QUANTITATION OF BISPHENOL A AND BISPHENOL A GLUCURONIDE IN BIOLOGICAL SAMPLES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
Wolfgang Völkel, Nataly Bittner and Wolfgang Dekant

Drug Metabolism and Disposition November 2005, 33 (11) 1748-1757; DOI: https://doi.org/10.1124/dmd.105.005454

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