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ALTERED AZT (3′-AZIDO-3′-DEOXYTHYMIDINE) GLUCURONIDATION KINETICS IN LIVER MICROSOMES AS AN EXPLANATION FOR UNDERPREDICTION OF IN VIVO CLEARANCE: COMPARISON TO HEPATOCYTES AND EFFECT OF INCUBATION ENVIRONMENT

Juntyma J. Engtrakul, Robert S. Foti, Timothy J. Strelevitz and Michael B. Fisher
Drug Metabolism and Disposition November 2005, 33 (11) 1621-1627; DOI: https://doi.org/10.1124/dmd.105.005058

Article Information

vol. 33 no. 11 1621-1627
DOI 
https://doi.org/10.1124/dmd.105.005058
PubMed 
16049128
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 7, 2005
  • Accepted July 22, 2005
  • Published online October 26, 2005.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Juntyma J. Engtrakul,
  2. Robert S. Foti,
  3. Timothy J. Strelevitz and
  4. Michael B. Fisher
  1. Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Groton, Connecticut
  1. Address correspondence to:
    Michael B. Fisher, Pfizer Inc., PGRD, Eastern Point Rd., Groton, CT 06340. E-mail: michael_fisher{at}groton.pfizer.com
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Research ArticleArticle

ALTERED AZT (3′-AZIDO-3′-DEOXYTHYMIDINE) GLUCURONIDATION KINETICS IN LIVER MICROSOMES AS AN EXPLANATION FOR UNDERPREDICTION OF IN VIVO CLEARANCE: COMPARISON TO HEPATOCYTES AND EFFECT OF INCUBATION ENVIRONMENT

Juntyma J. Engtrakul, Robert S. Foti, Timothy J. Strelevitz and Michael B. Fisher
Drug Metabolism and Disposition November 1, 2005, 33 (11) 1621-1627; DOI: https://doi.org/10.1124/dmd.105.005058
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