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IN VITRO METABOLISM OF THE CALMODULIN ANTAGONIST DY-9760e (3-[2-[4-(3-CHLORO-2-METHYLPHENYL)-1-PIPERAZINYL]ETHYL]-5,6-DIMETHOXY-1-(4-IMIDAZOLYLMETHYL)-1H-INDAZOLE DIHYDROCHLORIDE 3.5 HYDRATE) BY HUMAN LIVER MICROSOMES: INVOLVEMENT OF CYTOCHROMES P450 IN ATYPICAL KINETICS AND POTENTIAL DRUG INTERACTIONS

Shuko Tachibana, Yuko Fujimaki, Hiroyuki Yokoyama, Osamu Okazaki and Ken-ichi Sudo
Drug Metabolism and Disposition November 2005, 33 (11) 1628-1636; DOI: https://doi.org/10.1124/dmd.105.004903

Article Information

vol. 33 no. 11 1628-1636
DOI 
https://doi.org/10.1124/dmd.105.004903
PubMed 
16049129
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 1, 2005
  • Accepted July 22, 2005
  • Published online October 26, 2005.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Shuko Tachibana,
  2. Yuko Fujimaki,
  3. Hiroyuki Yokoyama,
  4. Osamu Okazaki and
  5. Ken-ichi Sudo
  1. Drug Metabolism and Physicochemistry Research Laboratories, R&D Division, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan (S.T., Y.F., O.O., K.S.); and Mitsubishi Chemical Safety Institute Ltd., Kashima Laboratory, Ibaraki, Japan (H.Y.)
  1. Address correspondence to:
    Shuko Tachibana, Drug Metabolism & Physicochemistry Research Laboratories, R&D Division, Daiichi Pharmaceutical Co., Ltd., 1-16-13, Kita-kasai, Edogawa-ku, Tokyo 134-8630, Japan. E-mail: tachiroq{at}daiichipharm.co.jp
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IN VITRO METABOLISM OF THE CALMODULIN ANTAGONIST DY-9760e (3-[2-[4-(3-CHLORO-2-METHYLPHENYL)-1-PIPERAZINYL]ETHYL]-5,6-DIMETHOXY-1-(4-IMIDAZOLYLMETHYL)-1H-INDAZOLE DIHYDROCHLORIDE 3.5 HYDRATE) BY HUMAN LIVER MICROSOMES: INVOLVEMENT OF CYTOCHROMES P450 IN ATYPICAL KINETICS AND POTENTIAL DRUG INTERACTIONS

Shuko Tachibana, Yuko Fujimaki, Hiroyuki Yokoyama, Osamu Okazaki and Ken-ichi Sudo
Drug Metabolism and Disposition November 1, 2005, 33 (11) 1628-1636; DOI: https://doi.org/10.1124/dmd.105.004903
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