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Research ArticleArticle

FORMATION OF TAMOXIFEN-DNA ADDUCTS VIA O-SULFONATION, NOT O-ACETYLATION, OF α-HYDROXYTAMOXIFEN IN RAT AND HUMAN LIVERS

Sung Yeon Kim, Y. R. Santosh Laxmi, Naomi Suzuki, Kenichiro Ogura, Tadashi Watabe, Michael W. Duffel and Shinya Shibutani
Drug Metabolism and Disposition November 2005, 33 (11) 1673-1678; DOI: https://doi.org/10.1124/dmd.105.005330

Article Information

vol. 33 no. 11 1673-1678
DOI 
https://doi.org/10.1124/dmd.105.005330
PubMed 
16099924
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 26, 2005
  • Accepted August 11, 2005
  • Published online October 26, 2005.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sung Yeon Kim,
  2. Y. R. Santosh Laxmi,
  3. Naomi Suzuki,
  4. Kenichiro Ogura,
  5. Tadashi Watabe,
  6. Michael W. Duffel and
  7. Shinya Shibutani
  1. Laboratory of Chemical Biology, Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York (S.Y.K., Y.R.S.L., N.S., S.S.); Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji-shi, Tokyo, Japan (K.O., T.W.); and Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa (M.W.D.)
  1. Address correspondence to:
    Shinya Shibutani, Department of Pharmacological Sciences, State University of New York at Stony Brook, 1 Nicolls Road, Stony Brook, NY 11794-8651. E-mail address: shinya{at}pharm.stonybrook.edu
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Research ArticleArticle

FORMATION OF TAMOXIFEN-DNA ADDUCTS VIA O-SULFONATION, NOT O-ACETYLATION, OF α-HYDROXYTAMOXIFEN IN RAT AND HUMAN LIVERS

Sung Yeon Kim, Y. R. Santosh Laxmi, Naomi Suzuki, Kenichiro Ogura, Tadashi Watabe, Michael W. Duffel and Shinya Shibutani
Drug Metabolism and Disposition November 1, 2005, 33 (11) 1673-1678; DOI: https://doi.org/10.1124/dmd.105.005330
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