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Drug Metabolism & Disposition

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Table of Contents

December 01, 2005; Volume 33,Issue 12

Editor's Note

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    James R. Halpert
    Drug Metabolism and Disposition December 2005, 33 (12) 1759; DOI: https://doi.org/10.1124/dmd.33.12.1759

Short Communications

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    NICOTINE AND 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-BUTANONE METABOLISM BY CYTOCHROME P450 2B6
    Kari E. Dicke, Sara M. Skrlin and Sharon E. Murphy
    Drug Metabolism and Disposition December 2005, 33 (12) 1760-1764; DOI: https://doi.org/10.1124/dmd.105.006718
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    TRANSAMINATION IN THE METABOLISM OF THE NEPHROTOXICANT N-(3,5-DICHLOROPHENYL)SUCCINIMIDE IN RATS
    Donghui Cui, Gary O. Rankin and Peter J. Harvison
    Drug Metabolism and Disposition December 2005, 33 (12) 1765-1770; DOI: https://doi.org/10.1124/dmd.105.006593

Articles

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    MODULATION OF HUMAN CYTOCHROME P450 1B1 EXPRESSION BY 2,4,3′,5′-TETRAMETHOXYSTILBENE
    Young-Jin Chun, Sang-Kwang Lee and Mie Young Kim
    Drug Metabolism and Disposition December 2005, 33 (12) 1771-1776; DOI: https://doi.org/10.1124/dmd.105.006502
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    DISPOSITION OF FLAVONOIDS VIA RECYCLING: COMPARISON OF INTESTINAL VERSUS HEPATIC DISPOSITION
    Jun Chen, Stephen Wang, Xiaobin Jia, Susan Bajimaya, Huimin Lin, Vincent H. Tam and Ming Hu
    Drug Metabolism and Disposition December 2005, 33 (12) 1777-1784; DOI: https://doi.org/10.1124/dmd.105.003673
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    GEFITINIB (IRESSA) INHIBITS THE CYP3A4-MEDIATED FORMATION OF 7-ETHYL-10-(4-AMINO-1-PIPERIDINO)CARBONYLOXYCAMPTOTHECIN BUT ACTIVATES THAT OF 7-ETHYL-10-[4-N-(5-AMINOPENTANOIC ACID)-1-PIPERIDINO]CARBONYLOXYCAMPTOTHECIN FROM IRINOTECAN
    Ken-ichi Fujita, Yuichi Ando, Masaru Narabayashi, Toshimichi Miya, Fumio Nagashima, Wataru Yamamoto, Keiji Kodama, Kazuhiro Araki, Hisashi Endo and Yasutsuna Sasaki
    Drug Metabolism and Disposition December 2005, 33 (12) 1785-1790; DOI: https://doi.org/10.1124/dmd.105.006205
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    INVOLVEMENT OF URIC ACID TRANSPORTER IN INCREASED RENAL CLEARANCE OF THE XANTHINE OXIDASE INHIBITOR OXYPURINOL INDUCED BY A URICOSURIC AGENT, BENZBROMARONE
    Takashi Iwanaga, Daisuke Kobayashi, Masamichi Hirayama, Tomoji Maeda and Ikumi Tamai
    Drug Metabolism and Disposition December 2005, 33 (12) 1791-1795; DOI: https://doi.org/10.1124/dmd.105.006056
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    GLYCOSIDATION OF AN ENDOTHELIN ETA RECEPTOR ANTAGONIST AND DICLOFENAC IN HUMAN LIVER MICROSOMES: AGLYCONE-DEPENDENT UDP-SUGAR SELECTIVITY
    Cuyue Tang and Bennett Ma
    Drug Metabolism and Disposition December 2005, 33 (12) 1796-1802; DOI: https://doi.org/10.1124/dmd.105.005801
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    SIMULTANEOUS MEASUREMENT OF 23 ISOFORMS FROM THE HUMAN CYTOCHROME P450 FAMILIES 1 TO 3 BY QUANTITATIVE REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION
    Igor Girault, Nathalie Rougier, Christophe Chesné, Rosette Lidereau, Philippe Beaune, Ivan Bieche and Isabelle de Waziers
    Drug Metabolism and Disposition December 2005, 33 (12) 1803-1810; DOI: https://doi.org/10.1124/dmd.105.005173
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    CYP2A6 AND CYP2B6 ARE INVOLVED IN NORNICOTINE FORMATION FROM NICOTINE IN HUMANS: INTERINDIVIDUAL DIFFERENCES IN THESE CONTRIBUTIONS
    Hiroyuki Yamanaka, Miki Nakajima, Tatsuki Fukami, Haruko Sakai, Akiko Nakamura, Miki Katoh, Masataka Takamiya, Yasuhiro Aoki and Tsuyoshi Yokoi
    Drug Metabolism and Disposition December 2005, 33 (12) 1811-1818; DOI: https://doi.org/10.1124/dmd.105.006254
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    PATHWAYS OF CARBAMAZEPINE BIOACTIVATION IN VITRO: II. THE ROLE OF HUMAN CYTOCHROME P450 ENZYMES IN THE FORMATION OF 2-HYDROXYIMINOSTILBENE
    Robin E. Pearce, Jack P. Uetrecht and J. Steven Leeder
    Drug Metabolism and Disposition December 2005, 33 (12) 1819-1826; DOI: https://doi.org/10.1124/dmd.105.004861
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    ROLE OF THE NUCLEAR RECEPTOR PREGNANE X RECEPTOR IN ACETAMINOPHEN HEPATOTOXICITY
    Kristina K. Wolf, Sheryl G. Wood, Jane A. Hunt, Brooke W. Walton-Strong, Kazuto Yasuda, Lubin Lan, Su X. Duan, Qin Hao, Steven A. Wrighton, Elizabeth H. Jeffery, Ronald M. Evans, Juliana G. Szakacs, Lisa L. von Moltke, David J. Greenblatt, Michael H. Court, Erin G. Schuetz, Peter R. Sinclair and Jacqueline F. Sinclair
    Drug Metabolism and Disposition December 2005, 33 (12) 1827-1836; DOI: https://doi.org/10.1124/dmd.105.005256
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    OXIDATION OF CAFFEINE BY CYP1A2: ISOTOPE EFFECTS AND METABOLIC SWITCHING
    Kelly A. Regal, Kent L. Kunze, Raimund M. Peter and Sidney D. Nelson
    Drug Metabolism and Disposition December 2005, 33 (12) 1837-1844; DOI: https://doi.org/10.1124/dmd.105.006031
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    FUNCTIONAL CHARACTERIZATION OF HUMAN MONOCARBOXYLATE TRANSPORTER 6 (SLC16A5)
    Yuichi Murakami, Noriko Kohyama, Yasuna Kobayashi, Masayuki Ohbayashi, Hisakazu Ohtani, Yasufumi Sawada and Toshinori Yamamoto
    Drug Metabolism and Disposition December 2005, 33 (12) 1845-1851; DOI: https://doi.org/10.1124/dmd.105.005264
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    PREDICTION OF METABOLIC CLEARANCE USING CRYOPRESERVED HUMAN HEPATOCYTES: KINETIC CHARACTERISTICS FOR FIVE BENZODIAZEPINES
    David Hallifax, Helen C. Rawden, Nancy Hakooz and J. Brian Houston
    Drug Metabolism and Disposition December 2005, 33 (12) 1852-1858; DOI: https://doi.org/10.1124/dmd.105.005389
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    EFFECT OF PROPIVERINE ON CYTOCHROME P450 ENZYMES: A COCKTAIL INTERACTION STUDY IN HEALTHY VOLUNTEERS
    D. Tomalik-Scharte, A. Jetter, M. Kinzig-Schippers, A. Skott, F. Sörgel, T. Klaassen, D. Kasel, S. Harlfinger, O. Doroshyenko, D. Frank, J. Kirchheiner, M. Bräter, K. Richter, T. Gramatté and U. Fuhr
    Drug Metabolism and Disposition December 2005, 33 (12) 1859-1866; DOI: https://doi.org/10.1124/dmd.105.005272
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    BIOACTIVATION OF 4-METHYLPHENOL (p-CRESOL) VIA CYTOCHROME P450-MEDIATED AROMATIC OXIDATION IN HUMAN LIVER MICROSOMES
    Zhengyin Yan, H. Marlon Zhong, Noureddine Maher, Rhoda Torres, Gregory C. Leo, Gary W. Caldwell and Norman Huebert
    Drug Metabolism and Disposition December 2005, 33 (12) 1867-1876; DOI: https://doi.org/10.1124/dmd.105.006387
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    SATURATION TOXICOKINETICS OF THIOACETAMIDE: ROLE IN INITIATION OF LIVER INJURY
    Jaya Chilakapati, Kartik Shankar, Midhun C. Korrapati, Ronald A. Hill and Harihara M. Mehendale
    Drug Metabolism and Disposition December 2005, 33 (12) 1877-1885; DOI: https://doi.org/10.1124/dmd.105.005520
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    UNUSUAL DEHYDROXYLATION OF ANTIMICROBIAL AMIDOXIME PRODRUGS BY CYTOCHROME b5 AND NADH CYTOCHROME b5 REDUCTASE
    Janelle Y. Saulter, Joseph R. Kurian, Lauren A. Trepanier, Richard R. Tidwell, Arlene S. Bridges, David W. Boykin, Chad E. Stephens, Mariappan Anbazhagan and James Edwin Hall
    Drug Metabolism and Disposition December 2005, 33 (12) 1886-1893; DOI: https://doi.org/10.1124/dmd.105.005017
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    SPECIES DIFFERENCES IN THE ELIMINATION OF A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR AGONIST HIGHLIGHTED BY OXIDATIVE METABOLISM OF ITS ACYL GLUCURONIDE
    Christopher J. Kochansky, Yuan-Qing Xia, Sui Wang, Brian Cato, Mellissa Creighton, Stella H. Vincent, Ronald B. Franklin and James R. Reed
    Drug Metabolism and Disposition December 2005, 33 (12) 1894-1904; DOI: https://doi.org/10.1124/dmd.105.004010
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    FUNCTIONAL ANALYSIS OF THREE CYP1A2 VARIANTS FOUND IN A JAPANESE POPULATION
    Yoshiro Saito, Nobumitsu Hanioka, Keiko Maekawa, Takashi Isobe, Yumi Tsuneto, Ryosuke Nakamura, Akiko Soyama, Shogo Ozawa, Toshiko Tanaka-Kagawa, Hideto Jinno, Shizuo Narimatsu and Jun-ichi Sawada
    Drug Metabolism and Disposition December 2005, 33 (12) 1905-1910; DOI: https://doi.org/10.1124/dmd.105.005819
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    HYDROLYSIS OF ANGIOTENSIN II RECEPTOR BLOCKER PRODRUG OLMESARTAN MEDOXOMIL BY HUMAN SERUM ALBUMIN AND IDENTIFICATION OF ITS CATALYTIC ACTIVE SITES
    Shen-Feng Ma, Makoto Anraku, Yasunori Iwao, Keishi Yamasaki, Ulrich Kragh-Hansen, Noriyuki Yamaotsu, Shuichi Hirono, Toshihiko Ikeda and Masaki Otagiri
    Drug Metabolism and Disposition December 2005, 33 (12) 1911-1919; DOI: https://doi.org/10.1124/dmd.105.006163

Accelerated Communication

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    HUMAN IN VITRO GLUTATHIONYL AND PROTEIN ADDUCTS OF CARBAMAZEPINE-10,11-EPOXIDE, A STABLE AND PHARMACOLOGICALLY ACTIVE METABOLITE OF CARBAMAZEPINE
    Hai-Zhi Bu, Ping Kang, Alan J. Deese, Ping Zhao and William F. Pool
    Drug Metabolism and Disposition December 2005, 33 (12) 1920-1924; DOI: https://doi.org/10.1124/dmd.105.006866

Errata

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    CORRECTIONS TO “HUMAN UDP-GLUCURONOSYLTRANSFERASES: ISOFORM SELECTIVITY AND KINETICS OF 4-METHYLUMBELLIFERONE AND 1-NAPHTHOL GLUCURONIDATION, EFFECTS OF ORGANIC SOLVENTS, AND INHIBITION BY DICLOFENAC AND PROBENECID”
    Drug Metabolism and Disposition December 2005, 33 (12) 1925-1926; DOI: https://doi.org/10.1124/dmd.33.12.1925
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    CORRECTION TO “SUPPRESSION OF CYTOCHROME P450 2C11 BY AROMATIC HYDROCARBONS: MECHANISTIC INSIGHTS FROM STUDIES OF THE 5′-FLANKING REGION OF THE CYP2C11 GENE”
    Drug Metabolism and Disposition December 2005, 33 (12) 1927; DOI: https://doi.org/10.1124/dmd.33.12.1927
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Drug Metabolism and Disposition: 33 (12)
Drug Metabolism and Disposition
Vol. 33, Issue 12
1 Dec 2005
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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