Table of Contents

Articles

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  MODULATION OF HUMAN CYTOCHROME P450 1B1 EXPRESSION BY 2,4,3′,5′-TETRAMETHOXYSTILBENE

  Young-Jin Chun, Sang-Kwang Lee and Mie Young Kim

  Drug Metabolism and Disposition December 2005, 33 (12) 1771-1776; DOI: https://doi.org/10.1124/dmd.105.006502
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  DISPOSITION OF FLAVONOIDS VIA RECYCLING: COMPARISON OF INTESTINAL VERSUS HEPATIC DISPOSITION

  Jun Chen, Stephen Wang, Xiaobin Jia, Susan Bajimaya, Huimin Lin, Vincent H. Tam and Ming Hu

  Drug Metabolism and Disposition December 2005, 33 (12) 1777-1784; DOI: https://doi.org/10.1124/dmd.105.003673
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  GEFITINIB (IRESSA) INHIBITS THE CYP3A4-MEDIATED FORMATION OF 7-ETHYL-10-(4-AMINO-1-PIPERIDINO)CARBONYLOXYCAMPTOTHECIN BUT ACTIVATES THAT OF 7-ETHYL-10-[4-N-(5-AMINOPENTANOIC ACID)-1-PIPERIDINO]CARBONYLOXYCAMPTOTHECIN FROM IRINOTECAN

  Ken-ichi Fujita, Yuichi Ando, Masaru Narabayashi, Toshimichi Miya, Fumio Nagashima, Wataru Yamamoto, Keiji Kodama, Kazuhiro Araki, Hisashi Endo and Yasutsuna Sasaki

  Drug Metabolism and Disposition December 2005, 33 (12) 1785-1790; DOI: https://doi.org/10.1124/dmd.105.006205
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  INVOLVEMENT OF URIC ACID TRANSPORTER IN INCREASED RENAL CLEARANCE OF THE XANTHINE OXIDASE INHIBITOR OXYPURINOL INDUCED BY A URICOSURIC AGENT, BENZBROMARONE

  Takashi Iwanaga, Daisuke Kobayashi, Masamichi Hirayama, Tomoji Maeda and Ikumi Tamai

  Drug Metabolism and Disposition December 2005, 33 (12) 1791-1795; DOI: https://doi.org/10.1124/dmd.105.006056
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  GLYCOSIDATION OF AN ENDOTHELIN ET_A RECEPTOR ANTAGONIST AND DICLOFENAC IN HUMAN LIVER MICROSOMES: AGLYCONE-DEPENDENT UDP-SUGAR SELECTIVITY

  Cuyue Tang and Bennett Ma

  Drug Metabolism and Disposition December 2005, 33 (12) 1796-1802; DOI: https://doi.org/10.1124/dmd.105.005801
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  SIMULTANEOUS MEASUREMENT OF 23 ISOFORMS FROM THE HUMAN CYTOCHROME P450 FAMILIES 1 TO 3 BY QUANTITATIVE REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION

  Igor Girault, Nathalie Rougier, Christophe Chesné, Rosette Lidereau, Philippe Beaune, Ivan Bieche and Isabelle de Waziers

  Drug Metabolism and Disposition December 2005, 33 (12) 1803-1810; DOI: https://doi.org/10.1124/dmd.105.005173
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  CYP2A6 AND CYP2B6 ARE INVOLVED IN NORNICOTINE FORMATION FROM NICOTINE IN HUMANS: INTERINDIVIDUAL DIFFERENCES IN THESE CONTRIBUTIONS

  Hiroyuki Yamanaka, Miki Nakajima, Tatsuki Fukami, Haruko Sakai, Akiko Nakamura, Miki Katoh, Masataka Takamiya, Yasuhiro Aoki and Tsuyoshi Yokoi

  Drug Metabolism and Disposition December 2005, 33 (12) 1811-1818; DOI: https://doi.org/10.1124/dmd.105.006254
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  PATHWAYS OF CARBAMAZEPINE BIOACTIVATION IN VITRO: II. THE ROLE OF HUMAN CYTOCHROME P450 ENZYMES IN THE FORMATION OF 2-HYDROXYIMINOSTILBENE

  Robin E. Pearce, Jack P. Uetrecht and J. Steven Leeder

  Drug Metabolism and Disposition December 2005, 33 (12) 1819-1826; DOI: https://doi.org/10.1124/dmd.105.004861
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  ROLE OF THE NUCLEAR RECEPTOR PREGNANE X RECEPTOR IN ACETAMINOPHEN HEPATOTOXICITY

  Kristina K. Wolf, Sheryl G. Wood, Jane A. Hunt, Brooke W. Walton-Strong, Kazuto Yasuda, Lubin Lan, Su X. Duan, Qin Hao, Steven A. Wrighton, Elizabeth H. Jeffery, Ronald M. Evans, Juliana G. Szakacs, Lisa L. von Moltke, David J. Greenblatt, Michael H. Court, Erin G. Schuetz, Peter R. Sinclair and Jacqueline F. Sinclair

  Drug Metabolism and Disposition December 2005, 33 (12) 1827-1836; DOI: https://doi.org/10.1124/dmd.105.005256
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  OXIDATION OF CAFFEINE BY CYP1A2: ISOTOPE EFFECTS AND METABOLIC SWITCHING

  Kelly A. Regal, Kent L. Kunze, Raimund M. Peter and Sidney D. Nelson

  Drug Metabolism and Disposition December 2005, 33 (12) 1837-1844; DOI: https://doi.org/10.1124/dmd.105.006031
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  FUNCTIONAL CHARACTERIZATION OF HUMAN MONOCARBOXYLATE TRANSPORTER 6 (SLC16A5)

  Yuichi Murakami, Noriko Kohyama, Yasuna Kobayashi, Masayuki Ohbayashi, Hisakazu Ohtani, Yasufumi Sawada and Toshinori Yamamoto

  Drug Metabolism and Disposition December 2005, 33 (12) 1845-1851; DOI: https://doi.org/10.1124/dmd.105.005264
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  PREDICTION OF METABOLIC CLEARANCE USING CRYOPRESERVED HUMAN HEPATOCYTES: KINETIC CHARACTERISTICS FOR FIVE BENZODIAZEPINES

  David Hallifax, Helen C. Rawden, Nancy Hakooz and J. Brian Houston

  Drug Metabolism and Disposition December 2005, 33 (12) 1852-1858; DOI: https://doi.org/10.1124/dmd.105.005389
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  EFFECT OF PROPIVERINE ON CYTOCHROME P450 ENZYMES: A COCKTAIL INTERACTION STUDY IN HEALTHY VOLUNTEERS

  D. Tomalik-Scharte, A. Jetter, M. Kinzig-Schippers, A. Skott, F. Sörgel, T. Klaassen, D. Kasel, S. Harlfinger, O. Doroshyenko, D. Frank, J. Kirchheiner, M. Bräter, K. Richter, T. Gramatté and U. Fuhr

  Drug Metabolism and Disposition December 2005, 33 (12) 1859-1866; DOI: https://doi.org/10.1124/dmd.105.005272
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  BIOACTIVATION OF 4-METHYLPHENOL (p-CRESOL) VIA CYTOCHROME P450-MEDIATED AROMATIC OXIDATION IN HUMAN LIVER MICROSOMES

  Zhengyin Yan, H. Marlon Zhong, Noureddine Maher, Rhoda Torres, Gregory C. Leo, Gary W. Caldwell and Norman Huebert

  Drug Metabolism and Disposition December 2005, 33 (12) 1867-1876; DOI: https://doi.org/10.1124/dmd.105.006387
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  SATURATION TOXICOKINETICS OF THIOACETAMIDE: ROLE IN INITIATION OF LIVER INJURY

  Jaya Chilakapati, Kartik Shankar, Midhun C. Korrapati, Ronald A. Hill and Harihara M. Mehendale

  Drug Metabolism and Disposition December 2005, 33 (12) 1877-1885; DOI: https://doi.org/10.1124/dmd.105.005520
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  UNUSUAL DEHYDROXYLATION OF ANTIMICROBIAL AMIDOXIME PRODRUGS BY CYTOCHROME b₅ AND NADH CYTOCHROME b₅ REDUCTASE

  Janelle Y. Saulter, Joseph R. Kurian, Lauren A. Trepanier, Richard R. Tidwell, Arlene S. Bridges, David W. Boykin, Chad E. Stephens, Mariappan Anbazhagan and James Edwin Hall

  Drug Metabolism and Disposition December 2005, 33 (12) 1886-1893; DOI: https://doi.org/10.1124/dmd.105.005017
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  SPECIES DIFFERENCES IN THE ELIMINATION OF A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR AGONIST HIGHLIGHTED BY OXIDATIVE METABOLISM OF ITS ACYL GLUCURONIDE

  Christopher J. Kochansky, Yuan-Qing Xia, Sui Wang, Brian Cato, Mellissa Creighton, Stella H. Vincent, Ronald B. Franklin and James R. Reed

  Drug Metabolism and Disposition December 2005, 33 (12) 1894-1904; DOI: https://doi.org/10.1124/dmd.105.004010
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  FUNCTIONAL ANALYSIS OF THREE CYP1A2 VARIANTS FOUND IN A JAPANESE POPULATION

  Yoshiro Saito, Nobumitsu Hanioka, Keiko Maekawa, Takashi Isobe, Yumi Tsuneto, Ryosuke Nakamura, Akiko Soyama, Shogo Ozawa, Toshiko Tanaka-Kagawa, Hideto Jinno, Shizuo Narimatsu and Jun-ichi Sawada

  Drug Metabolism and Disposition December 2005, 33 (12) 1905-1910; DOI: https://doi.org/10.1124/dmd.105.005819
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  HYDROLYSIS OF ANGIOTENSIN II RECEPTOR BLOCKER PRODRUG OLMESARTAN MEDOXOMIL BY HUMAN SERUM ALBUMIN AND IDENTIFICATION OF ITS CATALYTIC ACTIVE SITES

  Shen-Feng Ma, Makoto Anraku, Yasunori Iwao, Keishi Yamasaki, Ulrich Kragh-Hansen, Noriyuki Yamaotsu, Shuichi Hirono, Toshihiko Ikeda and Masaki Otagiri

  Drug Metabolism and Disposition December 2005, 33 (12) 1911-1919; DOI: https://doi.org/10.1124/dmd.105.006163