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GEFITINIB (IRESSA) INHIBITS THE CYP3A4-MEDIATED FORMATION OF 7-ETHYL-10-(4-AMINO-1-PIPERIDINO)CARBONYLOXYCAMPTOTHECIN BUT ACTIVATES THAT OF 7-ETHYL-10-[4-N-(5-AMINOPENTANOIC ACID)-1-PIPERIDINO]CARBONYLOXYCAMPTOTHECIN FROM IRINOTECAN

Ken-ichi Fujita, Yuichi Ando, Masaru Narabayashi, Toshimichi Miya, Fumio Nagashima, Wataru Yamamoto, Keiji Kodama, Kazuhiro Araki, Hisashi Endo and Yasutsuna Sasaki
Drug Metabolism and Disposition December 2005, 33 (12) 1785-1790; DOI: https://doi.org/10.1124/dmd.105.006205

Article Information

vol. 33 no. 12 1785-1790
DOI 
https://doi.org/10.1124/dmd.105.006205
PubMed 
16123050
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 22, 2005
  • Accepted August 25, 2005
  • Published online November 23, 2005.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ken-ichi Fujita,
  2. Yuichi Ando,
  3. Masaru Narabayashi,
  4. Toshimichi Miya,
  5. Fumio Nagashima,
  6. Wataru Yamamoto,
  7. Keiji Kodama,
  8. Kazuhiro Araki,
  9. Hisashi Endo and
  10. Yasutsuna Sasaki
  1. Department of Clinical Oncology, Saitama Medical School, Saitama, Japan
  1. Address correspondence to:
    Dr. Ken-ichi Fujita, Department of Clinical Oncology, Saitama Medical School, 38 Morohongou, Moroyama-cho, Iruma-gun, Saitama, 350-0495, Japan. E-mail: fujitak{at}saitama-med.ac.jp
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Research ArticleArticle

GEFITINIB (IRESSA) INHIBITS THE CYP3A4-MEDIATED FORMATION OF 7-ETHYL-10-(4-AMINO-1-PIPERIDINO)CARBONYLOXYCAMPTOTHECIN BUT ACTIVATES THAT OF 7-ETHYL-10-[4-N-(5-AMINOPENTANOIC ACID)-1-PIPERIDINO]CARBONYLOXYCAMPTOTHECIN FROM IRINOTECAN

Ken-ichi Fujita, Yuichi Ando, Masaru Narabayashi, Toshimichi Miya, Fumio Nagashima, Wataru Yamamoto, Keiji Kodama, Kazuhiro Araki, Hisashi Endo and Yasutsuna Sasaki
Drug Metabolism and Disposition December 1, 2005, 33 (12) 1785-1790; DOI: https://doi.org/10.1124/dmd.105.006205
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