Table of Contents

Articles

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  MALATHION BIOACTIVATION IN THE HUMAN LIVER: THE CONTRIBUTION OF DIFFERENT CYTOCHROME P450 ISOFORMS

  Franca M. Buratti, Alessandra D'Aniello, Maria Teresa Volpe, Annarita Meneguz and Emanuela Testai

  Drug Metabolism and Disposition March 2005, 33 (3) 295-302; DOI: https://doi.org/10.1124/dmd.104.001693
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  METABOLISM OF ALFENTANIL BY CYTOCHROME P4503A (CYP3A) ENZYMES

  Theresa Mariero Klees, Pamela Sheffels, Ola Dale and Evan D. Kharasch

  Drug Metabolism and Disposition March 2005, 33 (3) 303-311; DOI: https://doi.org/10.1124/dmd.104.002709
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  MECHANISMS OF ARSENITE-MEDIATED DECREASES IN BENZO[K]FLUORANTHENE-INDUCED HUMAN CYTOCHROME P4501A1 LEVELS IN HEPG2 CELLS

  Erin E. Bessette, Michael J. Fasco, Brian T. Pentecost and Laurence S. Kaminsky

  Drug Metabolism and Disposition March 2005, 33 (3) 312-320; DOI: https://doi.org/10.1124/dmd.104.002212
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  NEW 4-ARYL-1,4-DIHYDROPYRIDINES AND 4-ARYLPYRIDINES AS P-GLYCOPROTEIN INHIBITORS

  Xiao-fei Zhou, Linping Zhang, Elaine Tseng, Elizabeth Scott-Ramsay, Jerome J. Schentag, Robert A. Coburn and Marilyn E. Morris

  Drug Metabolism and Disposition March 2005, 33 (3) 321-328; DOI: https://doi.org/10.1124/dmd.104.002089
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  PHARMACOKINETICS OF TACROLIMUS AND MYCOPHENOLIC ACID ARE ALTERED, BUT RECOVER AT DIFFERENT TIMES DURING HEPATIC REGENERATION IN RATS

  Hui Tian, Junhai Ou, Stephen C. Strom and Raman Venkataramanan

  Drug Metabolism and Disposition March 2005, 33 (3) 329-335; DOI: https://doi.org/10.1124/dmd.104.002287
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  HUMAN CYTOCHROME P450 2S1: LACK OF ACTIVITY IN THE METABOLIC ACTIVATION OF SEVERAL CIGARETTE SMOKE CARCINOGENS AND IN THE METABOLISM OF NICOTINE

  Shou-Lin Wang, Xiao-Yang He and Jun-Yan Hong

  Drug Metabolism and Disposition March 2005, 33 (3) 336-340; DOI: https://doi.org/10.1124/dmd.104.002923
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  FLAVONOIDS CHRYSIN AND BENZOFLAVONE, POTENT BREAST CANCER RESISTANCE PROTEIN INHIBITORS, HAVE NO SIGNIFICANT EFFECT ON TOPOTECAN PHARMACOKINETICS IN RATS OR MDR1A/1B (–/–) MICE

  Shuzhong Zhang, Xiaodong Wang, Kazuko Sagawa and Marilyn E. Morris

  Drug Metabolism and Disposition March 2005, 33 (3) 341-348; DOI: https://doi.org/10.1124/dmd.104.002501
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  DEVELOPMENT AND VALIDATION OF A HIGH-THROUGHPUT RADIOMETRIC CYP3A4/5 INHIBITION ASSAY USING TRITIATED TESTOSTERONE

  Annalise Di Marco, Isabella Marcucci, Maria Verdirame, José Pérez, Manuel Sanchez, Fernando Peláez, Ashok Chaudhary and Ralph Laufer

  Drug Metabolism and Disposition March 2005, 33 (3) 349-358; DOI: https://doi.org/10.1124/dmd.104.002873
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  DEVELOPMENT AND VALIDATION OF A HIGH-THROUGHPUT RADIOMETRIC CYP2C9 INHIBITION ASSAY USING TRITIATED DICLOFENAC

  Annalise Di Marco, Isabella Marcucci, Ashok Chaudhary, Marina Taliani and Ralph Laufer

  Drug Metabolism and Disposition March 2005, 33 (3) 359-364; DOI: https://doi.org/10.1124/dmd.104.002915
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  tert-BUTYLHYDROQUINONE IS A NOVEL ARYL HYDROCARBON RECEPTOR LIGAND

  Negar Gharavi and Ayman O. S. El-Kadi

  Drug Metabolism and Disposition March 2005, 33 (3) 365-372; DOI: https://doi.org/10.1124/dmd.104.002253
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  COMPARATIVE METABOLISM OF POLYCHLORINATED BIPHENYLS AND TISSUE DISTRIBUTION OF PERSISTENT METABOLITES IN RATS, HAMSTERS, AND GUINEA PIGS

  Koichi Haraguchi, Nobuyuki Koga and Yoshihisa Kato

  Drug Metabolism and Disposition March 2005, 33 (3) 373-380; DOI: https://doi.org/10.1124/dmd.104.002444
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  RELATIONSHIPS AMONG PLASMA [2-¹³C]URACIL CONCENTRATIONS, BREATH ¹³CO₂ EXPIRATION, AND DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) ACTIVITY IN THE LIVER IN NORMAL AND DPD-DEFICIENT DOGS

  Makoto Inada, Yukihiro Hirao, Toshihisa Koga, Minoru Itose, Jun-ichi Kunizaki, Takefumi Shimizu and Hitoshi Sato

  Drug Metabolism and Disposition March 2005, 33 (3) 381-387; DOI: https://doi.org/10.1124/dmd.104.001032
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  ASSESSMENT OF DRUG INTERACTIONS IN HEPATOBILIARY TRANSPORT USING RHODAMINE 123 IN SANDWICH-CULTURED RAT HEPATOCYTES

  Pieter P. Annaert and Kim L. R. Brouwer

  Drug Metabolism and Disposition March 2005, 33 (3) 388-394; DOI: https://doi.org/10.1124/dmd.104.001669
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  IN VITRO AND IN VIVO EVALUATION OF THE METABOLISM AND PHARMACOKINETICS OF SEBACOYL DINALBUPHINE

  Li-Heng Pao, Cheng-Huei Hsiong, Oliver Yoa-Pu Hu, Jhi-Jung Wang and Shung-Tai Ho

  Drug Metabolism and Disposition March 2005, 33 (3) 395-402; DOI: https://doi.org/10.1124/dmd.104.002451
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  REGIOSELECTIVE GLUCURONIDATION OF DENOPAMINE: MARKED SPECIES DIFFERENCES AND IDENTIFICATION OF HUMAN UDP-GLUCURONOSYLTRANSFERASE ISOFORM

  Hidefumi Kaji and Toshiyuki Kume

  Drug Metabolism and Disposition March 2005, 33 (3) 403-412; DOI: https://doi.org/10.1124/dmd.104.002667
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  SELECTIVE INHIBITION OF HUMAN CYTOCHROME P4502C8 BY MONTELUKAST

  Robert L. Walsky, R. Scott Obach, Emily A. Gaman, Jean-Paul R. Gleeson and William R. Proctor

  Drug Metabolism and Disposition March 2005, 33 (3) 413-418; DOI: https://doi.org/10.1124/dmd.104.002766
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  THE BINDING OF DRUGS TO HEPATOCYTES AND ITS RELATIONSHIP TO PHYSICOCHEMICAL PROPERTIES

  Rupert P. Austin, Patrick Barton, Sarfraz Mohmed and Robert J. Riley

  Drug Metabolism and Disposition March 2005, 33 (3) 419-425; DOI: https://doi.org/10.1124/dmd.104.002436
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  DO MEN AND WOMEN DIFFER IN PROXIMAL SMALL INTESTINAL CYP3A OR P-GLYCOPROTEIN EXPRESSION?

  Mary F. Paine, Shana S. Ludington, Mei-Ling Chen, Paul W. Stewart, Shiew-Mei Huang and Paul B. Watkins

  Drug Metabolism and Disposition March 2005, 33 (3) 426-433; DOI: https://doi.org/10.1124/dmd.104.002469
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  ROLE OF ORGANIC ANION TRANSPORTER OATP1B1 (OATP-C) IN HEPATIC UPTAKE OF IRINOTECAN AND ITS ACTIVE METABOLITE, 7-ETHYL-10-HYDROXYCAMPTOTHECIN: IN VITRO EVIDENCE AND EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISMS

  Takashi Nozawa, Hironobu Minami, Shigeki Sugiura, Akira Tsuji and Ikumi Tamai

  Drug Metabolism and Disposition March 2005, 33 (3) 434-439; DOI: https://doi.org/10.1124/dmd.104.001909
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  SATURABLE DISTRIBUTION OF TACRINE INTO THE STRIATAL EXTRACELLULAR FLUID OF THE RAT: EVIDENCE OF INVOLVEMENT OF MULTIPLE ORGANIC CATION TRANSPORTERS IN THE TRANSPORT

  Jong-Hyuk Sung, Kyung-Ha Yu, Jin-Sun Park, Takashi Tsuruo, Dae-Duk Kim, Chang-Koo Shim and Suk-Jae Chung

  Drug Metabolism and Disposition March 2005, 33 (3) 440-448; DOI: https://doi.org/10.1124/dmd.104.002220
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  THE CYP2E1-HUMANIZED TRANSGENIC MOUSE: ROLE OF CYP2E1 IN ACETAMINOPHEN HEPATOTOXICITY

  Connie Cheung, Ai-Ming Yu, Jerrold M. Ward, Kristopher W. Krausz, Taro E. Akiyama, Lionel Feigenbaum and Frank J. Gonzalez

  Drug Metabolism and Disposition March 2005, 33 (3) 449-457; DOI: https://doi.org/10.1124/dmd.104.002402
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  RACIAL VARIABILITY IN HAPLOTYPE FREQUENCIES OF UGT1A1 AND GLUCURONIDATION ACTIVITY OF A NOVEL SINGLE NUCLEOTIDE POLYMORPHISM 686C> T (P229L) FOUND IN AN AFRICAN-AMERICAN

  Nahoko Kaniwa, Kouichi Kurose, Hideto Jinno, Toshiko Tanaka-Kagawa, Yoshiro Saito, Mayumi Saeki, Jun-ichi Sawada, Masahiro Tohkin and Ryuichi Hasegawa

  Drug Metabolism and Disposition March 2005, 33 (3) 458-465; DOI: https://doi.org/10.1124/dmd.104.001800
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  CYTOCHROME P450-MEDIATED OXIDATION OF GLUCURONIDE DERIVATIVES: EXAMPLE OF ESTRADIOL-17β-GLUCURONIDE OXIDATION TO 2-HYDROXY-ESTRADIOL-17β-GLUCURONIDE BY CYP 2C8

  M. Delaforge, A. Pruvost, L. Perrin and F. André

  Drug Metabolism and Disposition March 2005, 33 (3) 466-473; DOI: https://doi.org/10.1124/dmd.104.002097