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Drug Metabolism & Disposition

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Table of Contents

April 01, 2005; Volume 33,Issue 4

Commentary

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    Commentary: David Kupfer, Ph.D., 1925–2004
    John Schenkman
    Drug Metabolism and Disposition April 2005, 33 (4) 483; DOI: https://doi.org/10.1124/dmd.105.003582

Short Communication

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    IDENTIFICATION OF A NOVEL GLUTATHIONE ADDUCT OF DICLOFENAC, 4′-HYDROXY-2′-GLUTATHION-DESCHLORO-DICLOFENAC, UPON INCUBATION WITH HUMAN LIVER MICROSOMES
    Li J. Yu, Yue Chen, Michael P. Deninno, Thomas N. O'Connell and Cornelis E. C. A. Hop
    Drug Metabolism and Disposition April 2005, 33 (4) 484-488; DOI: https://doi.org/10.1124/dmd.104.002840

Articles

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    METABOLISM OF MELATONIN BY HUMAN CYTOCHROMES P450
    Xiaochao Ma, Jeffrey R. Idle, Kristopher W. Krausz and Frank J. Gonzalez
    Drug Metabolism and Disposition April 2005, 33 (4) 489-494; DOI: https://doi.org/10.1124/dmd.104.002410
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    TRANSPORT OF THE DOPAMINE D2 AGONIST PRAMIPEXOLE BY RAT ORGANIC CATION TRANSPORTERS OCT1 AND OCT2 IN KIDNEY
    Naoki Ishiguro, Asami Saito, Kazutoshi Yokoyama, Makoto Morikawa, Takashi Igarashi and Ikumi Tamai
    Drug Metabolism and Disposition April 2005, 33 (4) 495-499; DOI: https://doi.org/10.1124/dmd.104.002519
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    CYTOCHROME P450 3A-MEDIATED METABOLISM OF BUSPIRONE IN HUMAN LIVER MICROSOMES
    Mingshe Zhu, Weiping Zhao, Humberto Jimenez, Donglu Zhang, Suresh Yeola, Renke Dai, Nimish Vachharajani and James Mitroka
    Drug Metabolism and Disposition April 2005, 33 (4) 500-507; DOI: https://doi.org/10.1124/dmd.104.000836
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    IN VITRO METABOLISM OF DIARYLPYRAZOLES, A NOVEL GROUP OF CANNABINOID RECEPTOR LIGANDS
    Qiang Zhang, Peng Ma, Weiqun Wang, Richard B. Cole and Guangdi Wang
    Drug Metabolism and Disposition April 2005, 33 (4) 508-517; DOI: https://doi.org/10.1124/dmd.104.001974
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    CITRUS JUICES INHIBIT THE FUNCTION OF HUMAN ORGANIC ANION-TRANSPORTING POLYPEPTIDE OATP-B
    Hiroki Satoh, Fumiaki Yamashita, Masayuki Tsujimoto, Hideyasu Murakami, Noriko Koyabu, Hisakazu Ohtani and Yasufumi Sawada
    Drug Metabolism and Disposition April 2005, 33 (4) 518-523; DOI: https://doi.org/10.1124/dmd.104.002337
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    EXPRESSION AND FUNCTION OF ABCB1 AND ABCG2 IN HUMAN PLACENTAL TISSUE
    Dhanashri Kolwankar, Douglas D. Glover, Joseph A. Ware and Timothy S. Tracy
    Drug Metabolism and Disposition April 2005, 33 (4) 524-529; DOI: https://doi.org/10.1124/dmd.104.002261
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    STRUCTURAL AND ENZYMATIC PARAMETERS THAT DETERMINE ALKYL DEHYDROGENATION/HYDROXYLATION OF CAPSAICINOIDS BY CYTOCHROME P450 ENZYMES
    Christopher A. Reilly and Garold S. Yost
    Drug Metabolism and Disposition April 2005, 33 (4) 530-536; DOI: https://doi.org/10.1124/dmd.104.001214
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    DIFFERENTIAL INTERACTION OF 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE INHIBITORS WITH ABCB1, ABCC2, AND OATP1B1
    Cuiping Chen, Rouchelle J. Mireles, Scott D. Campbell, Jian Lin, Jessica B. Mills, Jinghai J. Xu and Teresa A. Smolarek
    Drug Metabolism and Disposition April 2005, 33 (4) 537-546; DOI: https://doi.org/10.1124/dmd.104.002477
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    FUNCTIONAL INDUCTION AND DE-INDUCTION OF P-GLYCOPROTEIN BY ST. JOHN'S WORT AND ITS INGREDIENTS IN A HUMAN COLON ADENOCARCINOMA CELL LINE
    Run Tian, Noriko Koyabu, Satoshi Morimoto, Yukihiro Shoyama, Hisakazu Ohtani and Yasufumi Sawada
    Drug Metabolism and Disposition April 2005, 33 (4) 547-554; DOI: https://doi.org/10.1124/dmd.104.002485
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    ISOLATION AND IDENTIFICATION OF SEVEN GLUCURONIDE CONJUGATES OF ANDROGRAPHOLIDE IN HUMAN URINE
    Liang Cui, Feng Qiu and Xinsheng Yao
    Drug Metabolism and Disposition April 2005, 33 (4) 555-562; DOI: https://doi.org/10.1124/dmd.104.001958
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    HUMAN LIVER S9 FRACTIONS: METABOLISM OF DEHYDROEPIANDROSTERONE, EPIANDROSTERONE, AND RELATED 7-HYDROXYLATED DERIVATIVES
    Sonia Chalbot and Robert Morfin
    Drug Metabolism and Disposition April 2005, 33 (4) 563-569; DOI: https://doi.org/10.1124/dmd.104.003004
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    CHARACTERIZATION AND PARTIAL PURIFICATION OF THE RAT AND HUMAN ENZYME SYSTEMS ACTIVE IN THE REDUCTION OF N-HYDROXYMELAGATRAN AND BENZAMIDOXIME
    Susanne Andersson, Yvonne Hofmann, Åsa Nordling, Xue-qing Li, Sabina Nivelius, Tommy B. Andersson, Magnus Ingelman-Sundberg and Inger Johansson
    Drug Metabolism and Disposition April 2005, 33 (4) 570-578; DOI: https://doi.org/10.1124/dmd.104.002972
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    EFFECT OF EARLY PHASE ADJUVANT ARTHRITIS ON HEPATIC P450 ENZYMES AND PHARMACOKINETICS OF VERAPAMIL: AN ALTERNATIVE APPROACH TO THE USE OF AN ANIMAL MODEL OF INFLAMMATION FOR PHARMACOKINETIC STUDIES
    Spencer Ling and Fakhreddin Jamali
    Drug Metabolism and Disposition April 2005, 33 (4) 579-586; DOI: https://doi.org/10.1124/dmd.104.002360
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    SPECIES DIFFERENCES IN THE DISPOSITION OF THE CCR5 ANTAGONIST, UK-427,857, A NEW POTENTIAL TREATMENT FOR HIV
    Don K. Walker, Samantha Abel, Pierre Comby, Gary J. Muirhead, Angus N. R. Nedderman and Dennis A. Smith
    Drug Metabolism and Disposition April 2005, 33 (4) 587-595; DOI: https://doi.org/10.1124/dmd.104.002626
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    BUCOLOME, A POTENT BINDING INHIBITOR FOR FUROSEMIDE, ALTERS THE PHARMACOKINETICS AND DIURETIC EFFECT OF FUROSEMIDE: POTENTIAL FOR USE OF BUCOLOME TO RESTORE DIURETIC RESPONSE IN NEPHROTIC SYNDROME
    Norito Takamura, Toru Maruyama, Etsuo Chosa, Keiichi Kawai, Yasuhiro Tsutsumi, Yukie Uryu, Keishi Yamasaki, Tsuneo Deguchi and Masaki Otagiri
    Drug Metabolism and Disposition April 2005, 33 (4) 596-602; DOI: https://doi.org/10.1124/dmd.104.002782
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Drug Metabolism and Disposition: 33 (4)
Drug Metabolism and Disposition
Vol. 33, Issue 4
1 Apr 2005
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  • Commentary
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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