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Drug Metabolism & Disposition

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Table of Contents

May 01, 2005; Volume 33,Issue 5

MINIREVIEWS

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    METABOLISM-BASED DRUG-DRUG INTERACTIONS: WHAT DETERMINES INDIVIDUAL VARIABILITY IN CYTOCHROME P450 INDUCTION?
    Cuyue Tang, Jiunn H. Lin and Anthony Y. H. Lu
    Drug Metabolism and Disposition May 2005, 33 (5) 603-613; DOI: https://doi.org/10.1124/dmd.104.003236

Short Communications

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    TRANSPORT OF ANTHELMINTIC BENZIMIDAZOLE DRUGS BY BREAST CANCER RESISTANCE PROTEIN (BCRP/ABCG2)
    Gracia Merino, Johan W. Jonker, Els Wagenaar, Mivis M. Pulido, Antonio J. Molina, Ana I. Alvarez and Alfred H. Schinkel
    Drug Metabolism and Disposition May 2005, 33 (5) 614-618; DOI: https://doi.org/10.1124/dmd.104.003319
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    POSSIBLE INVOLVEMENT OF ORGANIC ANION TRANSPORTER 2 ON THE INTERACTION OF THEOPHYLLINE WITH ERYTHROMYCIN IN THE HUMAN LIVER
    Yasuna Kobayashi, Ryoko Sakai, Naomi Ohshiro, Masayuki Ohbayashi, Noriko Kohyama and Toshinori Yamamoto
    Drug Metabolism and Disposition May 2005, 33 (5) 619-622; DOI: https://doi.org/10.1124/dmd.104.003301

Articles

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    TISSUE DISTRIBUTION AND RECEPTOR-MEDIATED CLEARANCE OF ANTI-CD11A ANTIBODY IN MICE
    Greg P. Coffey, Judith A. Fox, Susanne Pippig, Susan Palmieri, Barbara Reitz, Michelle Gonzales, Anahid Bakshi, Josette Padilla-Eagar and Paul J. Fielder
    Drug Metabolism and Disposition May 2005, 33 (5) 623-629; DOI: https://doi.org/10.1124/dmd.104.002584
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    FUNCTIONAL CHARACTERIZATION OF FIVE NOVEL CYP2C8 VARIANTS, G171S, R186X, R186G, K247R, AND K383N, FOUND IN A JAPANESE POPULATION
    Hiroyuki Hichiya, Toshiko Tanaka-Kagawa, Akiko Soyama, Hideto Jinno, Satoru Koyano, Noriko Katori, Erika Matsushima, Shigehisa Uchiyama, Hiroshi Tokunaga, Hideo Kimura, Narihiro Minami, Masaaki Katoh, Kenji Sugai, Yu-ichi Goto, Tomohide Tamura, Noboru Yamamoto, Yuichiro Ohe, Hideo Kunitoh, Hiroshi Nokihara, Teruhiko Yoshida, Hironobu Minami, Nagahiro Saijo, Masanori Ando, Shogo Ozawa, Yoshiro Saito and Jun-ichi Sawada
    Drug Metabolism and Disposition May 2005, 33 (5) 630-636; DOI: https://doi.org/10.1124/dmd.105.003830
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    EXPRESSION, LOCALIZATION, AND FUNCTIONAL CHARACTERISTICS OF BREAST CANCER RESISTANCE PROTEIN IN CACO-2 CELLS
    Cindy Q. Xia, Ning Liu, David Yang, Gerald Miwa and Liang-Shang Gan
    Drug Metabolism and Disposition May 2005, 33 (5) 637-643; DOI: https://doi.org/10.1124/dmd.104.003442
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    EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME P450 3A (CYP3A) AND CARBAMAZEPINE PHARMACOKINETICS IN RATS
    Muneaki Hidaka, Manabu Okumura, Ken-ichi Fujita, Tetsuya Ogikubo, Keishi Yamasaki, Tomomi Iwakiri, Nao Setoguchi and Kazuhiko Arimori
    Drug Metabolism and Disposition May 2005, 33 (5) 644-648; DOI: https://doi.org/10.1124/dmd.104.002824
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    MOLECULAR CLONING, BACULOVIRUS EXPRESSION, AND TISSUE DISTRIBUTION OF THE ZEBRAFISH ALDEHYDE DEHYDROGENASE 2
    Natalie Lassen, Tia Estey, Robert L. Tanguay, Aglaia Pappa, Mark J. Reimers and Vasilis Vasiliou
    Drug Metabolism and Disposition May 2005, 33 (5) 649-656; DOI: https://doi.org/10.1124/dmd.104.002964
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    BIOSYNTHESIS OF DOBUTAMINE MONOGLUCURONIDES AND GLUCURONIDATION OF DOBUTAMINE BY RECOMBINANT HUMAN UDP-GLUCURONOSYLTRANSFERASES
    Anna Alonen, Olli Aitio, Kati Hakala, Leena Luukkanen, Moshe Finel and Risto Kostiainen
    Drug Metabolism and Disposition May 2005, 33 (5) 657-663; DOI: https://doi.org/10.1124/dmd.104.002139
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    DIFFERENTIAL MECHANISM-BASED INHIBITION OF CYP3A4 AND CYP3A5 BY VERAPAMIL
    Ying-Hong Wang, David R. Jones and Stephen D. Hall
    Drug Metabolism and Disposition May 2005, 33 (5) 664-671; DOI: https://doi.org/10.1124/dmd.104.001834
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    UDP-GLUCURONOSYLTRANSFERASE 1A4 POLYMORPHISMS IN A JAPANESE POPULATION AND KINETICS OF CLOZAPINE GLUCURONIDATION
    Asami Mori, Yoshihiro Maruo, Masaru Iwai, Hiroshi Sato and Yoshihiro Takeuchi
    Drug Metabolism and Disposition May 2005, 33 (5) 672-675; DOI: https://doi.org/10.1124/dmd.104.002576
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    HEPATIC UPTAKE OF THE NOVEL ANTIFUNGAL AGENT CASPOFUNGIN
    Punam Sandhu, Wooin Lee, Xin Xu, Brenda F. Leake, Masayo Yamazaki, Julie A. Stone, Jiunn H. Lin, Paul G. Pearson and Richard B. Kim
    Drug Metabolism and Disposition May 2005, 33 (5) 676-682; DOI: https://doi.org/10.1124/dmd.104.003244
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    RENAL-SELECTIVE DELIVERY AND ANGIOTENSIN-CONVERTING ENZYME INHIBITION BY SUBCUTANEOUSLY ADMINISTERED CAPTOPRIL-LYSOZYME
    Jai Prakash, Annemiek M. van Loenen-Weemaes, Marijke Haas, Johannes H. Proost, Dirk K. F. Meijer, Frits Moolenaar, Klaas Poelstra and Robbert J. Kok
    Drug Metabolism and Disposition May 2005, 33 (5) 683-688; DOI: https://doi.org/10.1124/dmd.104.002808
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    IN VITRO METABOLISM STUDY OF BUPRENORPHINE: EVIDENCE FOR NEW METABOLIC PATHWAYS
    Nicolas Picard, Thierry Cresteil, Nassim Djebli and Pierre Marquet
    Drug Metabolism and Disposition May 2005, 33 (5) 689-695; DOI: https://doi.org/10.1124/dmd.105.003681

Erratum

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    CORRECTION TO “BIOACTIVATION OF THE NONTRICYCLIC ANTIDEPRESSANT NEFAZODONE TO A REACTIVE QUINONEIMINE SPECIES IN HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROME P450 3A4”
    Drug Metabolism and Disposition May 2005, 33 (5) 696; DOI: https://doi.org/10.1124/dmd.33.5.
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Drug Metabolism and Disposition: 33 (5)
Drug Metabolism and Disposition
Vol. 33, Issue 5
1 May 2005
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  • MINIREVIEWS
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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