Table of Contents

Articles

• You have access

  FUNCTIONAL ANALYSIS OF THE HUMAN VARIANTS OF BREAST CANCER RESISTANCE PROTEIN: I206L, N590Y, AND D620N

  R. Robert Vethanayagam, Honggang Wang, Anshul Gupta, Yi Zhang, Fred Lewis, Jashvant D. Unadkat and Qingcheng Mao

  Drug Metabolism and Disposition June 2005, 33 (6) 697-705; DOI: https://doi.org/10.1124/dmd.105.003657
• You have access

  DETECTION OF A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES

  Zhengyin Yan, Jian Li, Norman Huebert, Gary W. Caldwell, Yanming Du and Hua Zhong

  Drug Metabolism and Disposition June 2005, 33 (6) 706-713; DOI: https://doi.org/10.1124/dmd.104.003095
• You have access

  CHARACTERIZATION OF TESTOSTERONE 11β-HYDROXYLATION CATALYZED BY HUMAN LIVER MICROSOMAL CYTOCHROMES P450

  Man Ho Choi, Paul L. Skipper, John S. Wishnok and Steven R. Tannenbaum

  Drug Metabolism and Disposition June 2005, 33 (6) 714-718; DOI: https://doi.org/10.1124/dmd.104.003327
• You have access

  METABOLISM OF THE CARDIOPROTECTIVE DRUG DEXRAZOXANE AND ONE OF ITS METABOLITES BY ISOLATED RAT MYOCYTES, HEPATOCYTES, AND BLOOD

  Patricia E. Schroeder, Gu-Qi Wang, Frank J. Burczynski and Brian B. Hasinoff

  Drug Metabolism and Disposition June 2005, 33 (6) 719-725; DOI: https://doi.org/10.1124/dmd.104.003186
• You have access

  NONLINEAR PHARMACOKINETICS OF PROPAFENONE IN RATS AND HUMANS: APPLICATION OF A SUBSTRATE DEPLETION ASSAY USING HEPATOCYTES FOR ASSESSMENT OF NONLINEARITY

  Hiroshi Komura and Masahiro Iwaki

  Drug Metabolism and Disposition June 2005, 33 (6) 726-732; DOI: https://doi.org/10.1124/dmd.104.002550
• You have access

  METABOLIC ACTIVATION OF PIOGLITAZONE IDENTIFIED FROM RAT AND HUMAN LIVER MICROSOMES AND FRESHLY ISOLATED HEPATOCYTES

  T. M. Baughman, R. A. Graham, K. Wells-Knecht, I. S. Silver, L. O. Tyler, M. Wells-Knecht and Z. Zhao

  Drug Metabolism and Disposition June 2005, 33 (6) 733-738; DOI: https://doi.org/10.1124/dmd.104.002683
• You have access

  THE DISTRIBUTION, METABOLISM, AND ELIMINATION OF CLOFARABINE IN RATS

  Peter L. Bonate, Larry Arthaud, John Stuhler, Phyllis Yerino, Randall J. Press and James Q. Rose

  Drug Metabolism and Disposition June 2005, 33 (6) 739-748; DOI: https://doi.org/10.1124/dmd.104.002592
• You have access

  ROLE OF CYP2C9 AND ITS VARIANTS (CYP2C9^*3 AND CYP2C9^*13) IN THE METABOLISM OF LORNOXICAM IN HUMANS

  Yingjie Guo, Yifan Zhang, Ying Wang, Xiaoyan Chen, Dayong Si, Dafang Zhong, J. Paul Fawcett and Hui Zhou

  Drug Metabolism and Disposition June 2005, 33 (6) 749-753; DOI: https://doi.org/10.1124/dmd.105.003616
• You have access

  IN VIVO INDUCTION OF HUMAN CYTOCHROME P450 ENZYMES EXPRESSED IN CHIMERIC MICE WITH HUMANIZED LIVER

  Miki Katoh, Tomohito Matsui, Miki Nakajima, Chise Tateno, Yoshinori Soeno, Toru Horie, Kazuhide Iwasaki, Katsutoshi Yoshizato and Tsuyoshi Yokoi

  Drug Metabolism and Disposition June 2005, 33 (6) 754-763; DOI: https://doi.org/10.1124/dmd.104.002600
• You have access

  ATAZANAVIR: EFFECTS ON P-GLYCOPROTEIN TRANSPORT AND CYP3A METABOLISM IN VITRO

  Elke S. Perloff, Su X. Duan, Paul R. Skolnik, David J. Greenblatt and Lisa L. von Moltke

  Drug Metabolism and Disposition June 2005, 33 (6) 764-770; DOI: https://doi.org/10.1124/dmd.104.002931
• You have access

  HUMAN METABOLISM OF THE PROTEASOME INHIBITOR BORTEZOMIB: IDENTIFICATION OF CIRCULATING METABOLITES

  Teresa Pekol, J. Scott Daniels, Jason Labutti, Ian Parsons, Darrell Nix, Elizabeth Baronas, Frank Hsieh, Liang-Shang Gan and Gerald Miwa

  Drug Metabolism and Disposition June 2005, 33 (6) 771-777; DOI: https://doi.org/10.1124/dmd.104.002956
• You have access

  METABOLISM OF 2α-PROPOXY-1α,25-DIHYDROXYVITAMIN D₃ AND 2α-(3-HYDROXYPROPOXY)-1α,25-DIHYDROXYVITAMIN D₃ BY HUMAN CYP27A1 AND CYP24A1

  Daisuke Abe, Toshiyuki Sakaki, Tatsuya Kusudo, Atsushi Kittaka, Nozomi Saito, Yoshitomo Suhara, Toshie Fujishima, Hiroaki Takayama, Hiromi Hamamoto, Masaki Kamakura, Miho Ohta and Kuniyo Inouye

  Drug Metabolism and Disposition June 2005, 33 (6) 778-784; DOI: https://doi.org/10.1124/dmd.104.003038
• You have access

  SPECIES- AND DISPOSITION MODEL-DEPENDENT METABOLISM OF RALOXIFENE IN GUT AND LIVER: ROLE OF UGT1A10

  Eun Ju Jeong, Yong Liu, Huimin Lin and Ming Hu

  Drug Metabolism and Disposition June 2005, 33 (6) 785-794; DOI: https://doi.org/10.1124/dmd.104.001883
• You have access

  THE NATURALLY OCCURRING CYTOCHROME P450 (P450) 2B6 K262R MUTANT OF P450 2B6 EXHIBITS ALTERATIONS IN SUBSTRATE METABOLISM AND INACTIVATION

  Namandjé N. Bumpus, Chitra Sridar, Ute M. Kent and Paul F. Hollenberg

  Drug Metabolism and Disposition June 2005, 33 (6) 795-802; DOI: https://doi.org/10.1124/dmd.105.003749
• You have access

  ACYL GLUCURONIDATION OF FLUOROQUINOLONE ANTIBIOTICS BY THE UDP-GLUCURONOSYLTRANSFERASE 1A SUBFAMILY IN HUMAN LIVER MICROSOMES

  Masaya Tachibana, Makoto Tanaka, Yasuhiro Masubuchi and Toshiharu Horie

  Drug Metabolism and Disposition June 2005, 33 (6) 803-811; DOI: https://doi.org/10.1124/dmd.104.003178
• You have access

  DETERMINATION OF DRUG GLUCURONIDATION AND UDP-GLUCURONOSYLTRANSFERASE SELECTIVITY USING A 96-WELL RADIOMETRIC ASSAY

  Annalise Di Marco, Michelle D'Antoni, Silvia Attaccalite, Pietro Carotenuto and Ralph Laufer

  Drug Metabolism and Disposition June 2005, 33 (6) 812-819; DOI: https://doi.org/10.1124/dmd.105.004333
• You have access

  IMPACT OF ENDOTOXIN-INDUCED CHANGES IN P-GLYCOPROTEIN EXPRESSION ON DISPOSITION OF DOXORUBICIN IN MICE

  Georgy Hartmann, Vessela Vassileva and Micheline Piquette-Miller

  Drug Metabolism and Disposition June 2005, 33 (6) 820-828; DOI: https://doi.org/10.1124/dmd.104.002568
• You have access

  ENZYME-SELECTIVE EFFECTS OF NITRIC OXIDE ON AFFINITY AND MAXIMUM VELOCITY OF VARIOUS RAT CYTOCHROMES P450

  Ragini Vuppugalla and Reza Mehvar

  Drug Metabolism and Disposition June 2005, 33 (6) 829-836; DOI: https://doi.org/10.1124/dmd.105.003848
• You have access

  IMPACT OF PARALLEL PATHWAYS OF DRUG ELIMINATION AND MULTIPLE CYTOCHROME P450 INVOLVEMENT ON DRUG-DRUG INTERACTIONS: CYP2D6 PARADIGM

  Kiyomi Ito, David Hallifax, R. Scott Obach and J. Brian Houston

  Drug Metabolism and Disposition June 2005, 33 (6) 837-844; DOI: https://doi.org/10.1124/dmd.105.003715
• You have access

  IN VITRO-IN VIVO EXTRAPOLATION OF CYP2D6 INACTIVATION BY PAROXETINE: PREDICTION OF NONSTATIONARY PHARMACOKINETICS AND DRUG INTERACTION MAGNITUDE

  Karthik Venkatakrishnan and R. Scott Obach

  Drug Metabolism and Disposition June 2005, 33 (6) 845-852; DOI: https://doi.org/10.1124/dmd.105.004077
• You have access

  EVALUATION OF TIME-DEPENDENT INACTIVATION OF CYP3A IN CRYOPRESERVED HUMAN HEPATOCYTES

  Ping Zhao, Kent L. Kunze and Caroline A. Lee

  Drug Metabolism and Disposition June 2005, 33 (6) 853-861; DOI: https://doi.org/10.1124/dmd.104.002832
• You have access

  MINIPIG CYTOCHROME P450 2E1: COMPARISON WITH HUMAN ENZYME

  Jana Baranová, Eva Anzenbacherová, Pavel Anzenbacher and Pavel Souček

  Drug Metabolism and Disposition June 2005, 33 (6) 862-865; DOI: https://doi.org/10.1124/dmd.104.003392
• You have access

  CYTOCHROME P450 3A4 IS THE MAJOR ENZYME RESPONSIBLE FOR THE METABOLISM OF LAQUINIMOD, A NOVEL IMMUNOMODULATOR

  Helén Tuvesson, Ingrid Hallin, Robert Persson, Birgitta Sparre, Per Olov Gunnarsson and Janeric Seidegård

  Drug Metabolism and Disposition June 2005, 33 (6) 866-872; DOI: https://doi.org/10.1124/dmd.104.002238