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Drug Metabolism & Disposition

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Table of Contents

June 01, 2005; Volume 33,Issue 6

Articles

  • You have access
    FUNCTIONAL ANALYSIS OF THE HUMAN VARIANTS OF BREAST CANCER RESISTANCE PROTEIN: I206L, N590Y, AND D620N
    R. Robert Vethanayagam, Honggang Wang, Anshul Gupta, Yi Zhang, Fred Lewis, Jashvant D. Unadkat and Qingcheng Mao
    Drug Metabolism and Disposition June 2005, 33 (6) 697-705; DOI: https://doi.org/10.1124/dmd.105.003657
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    DETECTION OF A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES
    Zhengyin Yan, Jian Li, Norman Huebert, Gary W. Caldwell, Yanming Du and Hua Zhong
    Drug Metabolism and Disposition June 2005, 33 (6) 706-713; DOI: https://doi.org/10.1124/dmd.104.003095
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    CHARACTERIZATION OF TESTOSTERONE 11β-HYDROXYLATION CATALYZED BY HUMAN LIVER MICROSOMAL CYTOCHROMES P450
    Man Ho Choi, Paul L. Skipper, John S. Wishnok and Steven R. Tannenbaum
    Drug Metabolism and Disposition June 2005, 33 (6) 714-718; DOI: https://doi.org/10.1124/dmd.104.003327
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    METABOLISM OF THE CARDIOPROTECTIVE DRUG DEXRAZOXANE AND ONE OF ITS METABOLITES BY ISOLATED RAT MYOCYTES, HEPATOCYTES, AND BLOOD
    Patricia E. Schroeder, Gu-Qi Wang, Frank J. Burczynski and Brian B. Hasinoff
    Drug Metabolism and Disposition June 2005, 33 (6) 719-725; DOI: https://doi.org/10.1124/dmd.104.003186
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    NONLINEAR PHARMACOKINETICS OF PROPAFENONE IN RATS AND HUMANS: APPLICATION OF A SUBSTRATE DEPLETION ASSAY USING HEPATOCYTES FOR ASSESSMENT OF NONLINEARITY
    Hiroshi Komura and Masahiro Iwaki
    Drug Metabolism and Disposition June 2005, 33 (6) 726-732; DOI: https://doi.org/10.1124/dmd.104.002550
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    METABOLIC ACTIVATION OF PIOGLITAZONE IDENTIFIED FROM RAT AND HUMAN LIVER MICROSOMES AND FRESHLY ISOLATED HEPATOCYTES
    T. M. Baughman, R. A. Graham, K. Wells-Knecht, I. S. Silver, L. O. Tyler, M. Wells-Knecht and Z. Zhao
    Drug Metabolism and Disposition June 2005, 33 (6) 733-738; DOI: https://doi.org/10.1124/dmd.104.002683
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    THE DISTRIBUTION, METABOLISM, AND ELIMINATION OF CLOFARABINE IN RATS
    Peter L. Bonate, Larry Arthaud, John Stuhler, Phyllis Yerino, Randall J. Press and James Q. Rose
    Drug Metabolism and Disposition June 2005, 33 (6) 739-748; DOI: https://doi.org/10.1124/dmd.104.002592
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    ROLE OF CYP2C9 AND ITS VARIANTS (CYP2C9*3 AND CYP2C9*13) IN THE METABOLISM OF LORNOXICAM IN HUMANS
    Yingjie Guo, Yifan Zhang, Ying Wang, Xiaoyan Chen, Dayong Si, Dafang Zhong, J. Paul Fawcett and Hui Zhou
    Drug Metabolism and Disposition June 2005, 33 (6) 749-753; DOI: https://doi.org/10.1124/dmd.105.003616
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    IN VIVO INDUCTION OF HUMAN CYTOCHROME P450 ENZYMES EXPRESSED IN CHIMERIC MICE WITH HUMANIZED LIVER
    Miki Katoh, Tomohito Matsui, Miki Nakajima, Chise Tateno, Yoshinori Soeno, Toru Horie, Kazuhide Iwasaki, Katsutoshi Yoshizato and Tsuyoshi Yokoi
    Drug Metabolism and Disposition June 2005, 33 (6) 754-763; DOI: https://doi.org/10.1124/dmd.104.002600
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    ATAZANAVIR: EFFECTS ON P-GLYCOPROTEIN TRANSPORT AND CYP3A METABOLISM IN VITRO
    Elke S. Perloff, Su X. Duan, Paul R. Skolnik, David J. Greenblatt and Lisa L. von Moltke
    Drug Metabolism and Disposition June 2005, 33 (6) 764-770; DOI: https://doi.org/10.1124/dmd.104.002931
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    HUMAN METABOLISM OF THE PROTEASOME INHIBITOR BORTEZOMIB: IDENTIFICATION OF CIRCULATING METABOLITES
    Teresa Pekol, J. Scott Daniels, Jason Labutti, Ian Parsons, Darrell Nix, Elizabeth Baronas, Frank Hsieh, Liang-Shang Gan and Gerald Miwa
    Drug Metabolism and Disposition June 2005, 33 (6) 771-777; DOI: https://doi.org/10.1124/dmd.104.002956
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    METABOLISM OF 2α-PROPOXY-1α,25-DIHYDROXYVITAMIN D3 AND 2α-(3-HYDROXYPROPOXY)-1α,25-DIHYDROXYVITAMIN D3 BY HUMAN CYP27A1 AND CYP24A1
    Daisuke Abe, Toshiyuki Sakaki, Tatsuya Kusudo, Atsushi Kittaka, Nozomi Saito, Yoshitomo Suhara, Toshie Fujishima, Hiroaki Takayama, Hiromi Hamamoto, Masaki Kamakura, Miho Ohta and Kuniyo Inouye
    Drug Metabolism and Disposition June 2005, 33 (6) 778-784; DOI: https://doi.org/10.1124/dmd.104.003038
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    SPECIES- AND DISPOSITION MODEL-DEPENDENT METABOLISM OF RALOXIFENE IN GUT AND LIVER: ROLE OF UGT1A10
    Eun Ju Jeong, Yong Liu, Huimin Lin and Ming Hu
    Drug Metabolism and Disposition June 2005, 33 (6) 785-794; DOI: https://doi.org/10.1124/dmd.104.001883
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    THE NATURALLY OCCURRING CYTOCHROME P450 (P450) 2B6 K262R MUTANT OF P450 2B6 EXHIBITS ALTERATIONS IN SUBSTRATE METABOLISM AND INACTIVATION
    Namandjé N. Bumpus, Chitra Sridar, Ute M. Kent and Paul F. Hollenberg
    Drug Metabolism and Disposition June 2005, 33 (6) 795-802; DOI: https://doi.org/10.1124/dmd.105.003749
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    ACYL GLUCURONIDATION OF FLUOROQUINOLONE ANTIBIOTICS BY THE UDP-GLUCURONOSYLTRANSFERASE 1A SUBFAMILY IN HUMAN LIVER MICROSOMES
    Masaya Tachibana, Makoto Tanaka, Yasuhiro Masubuchi and Toshiharu Horie
    Drug Metabolism and Disposition June 2005, 33 (6) 803-811; DOI: https://doi.org/10.1124/dmd.104.003178
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    DETERMINATION OF DRUG GLUCURONIDATION AND UDP-GLUCURONOSYLTRANSFERASE SELECTIVITY USING A 96-WELL RADIOMETRIC ASSAY
    Annalise Di Marco, Michelle D'Antoni, Silvia Attaccalite, Pietro Carotenuto and Ralph Laufer
    Drug Metabolism and Disposition June 2005, 33 (6) 812-819; DOI: https://doi.org/10.1124/dmd.105.004333
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    IMPACT OF ENDOTOXIN-INDUCED CHANGES IN P-GLYCOPROTEIN EXPRESSION ON DISPOSITION OF DOXORUBICIN IN MICE
    Georgy Hartmann, Vessela Vassileva and Micheline Piquette-Miller
    Drug Metabolism and Disposition June 2005, 33 (6) 820-828; DOI: https://doi.org/10.1124/dmd.104.002568
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    ENZYME-SELECTIVE EFFECTS OF NITRIC OXIDE ON AFFINITY AND MAXIMUM VELOCITY OF VARIOUS RAT CYTOCHROMES P450
    Ragini Vuppugalla and Reza Mehvar
    Drug Metabolism and Disposition June 2005, 33 (6) 829-836; DOI: https://doi.org/10.1124/dmd.105.003848
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    IMPACT OF PARALLEL PATHWAYS OF DRUG ELIMINATION AND MULTIPLE CYTOCHROME P450 INVOLVEMENT ON DRUG-DRUG INTERACTIONS: CYP2D6 PARADIGM
    Kiyomi Ito, David Hallifax, R. Scott Obach and J. Brian Houston
    Drug Metabolism and Disposition June 2005, 33 (6) 837-844; DOI: https://doi.org/10.1124/dmd.105.003715
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    IN VITRO-IN VIVO EXTRAPOLATION OF CYP2D6 INACTIVATION BY PAROXETINE: PREDICTION OF NONSTATIONARY PHARMACOKINETICS AND DRUG INTERACTION MAGNITUDE
    Karthik Venkatakrishnan and R. Scott Obach
    Drug Metabolism and Disposition June 2005, 33 (6) 845-852; DOI: https://doi.org/10.1124/dmd.105.004077
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    EVALUATION OF TIME-DEPENDENT INACTIVATION OF CYP3A IN CRYOPRESERVED HUMAN HEPATOCYTES
    Ping Zhao, Kent L. Kunze and Caroline A. Lee
    Drug Metabolism and Disposition June 2005, 33 (6) 853-861; DOI: https://doi.org/10.1124/dmd.104.002832
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    MINIPIG CYTOCHROME P450 2E1: COMPARISON WITH HUMAN ENZYME
    Jana Baranová, Eva Anzenbacherová, Pavel Anzenbacher and Pavel Souček
    Drug Metabolism and Disposition June 2005, 33 (6) 862-865; DOI: https://doi.org/10.1124/dmd.104.003392
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    CYTOCHROME P450 3A4 IS THE MAJOR ENZYME RESPONSIBLE FOR THE METABOLISM OF LAQUINIMOD, A NOVEL IMMUNOMODULATOR
    Helén Tuvesson, Ingrid Hallin, Robert Persson, Birgitta Sparre, Per Olov Gunnarsson and Janeric Seidegård
    Drug Metabolism and Disposition June 2005, 33 (6) 866-872; DOI: https://doi.org/10.1124/dmd.104.002238
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Drug Metabolism and Disposition: 33 (6)
Drug Metabolism and Disposition
Vol. 33, Issue 6
1 Jun 2005
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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