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DETECTION OF A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES

Zhengyin Yan, Jian Li, Norman Huebert, Gary W. Caldwell, Yanming Du and Hua Zhong
Drug Metabolism and Disposition June 2005, 33 (6) 706-713; DOI: https://doi.org/10.1124/dmd.104.003095

Article Information

vol. 33 no. 6 706-713
DOI 
https://doi.org/10.1124/dmd.104.003095
PubMed 
15764717
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 22, 2004
  • Accepted March 3, 2005
  • Published online May 16, 2005.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Zhengyin Yan,
  2. Jian Li,
  3. Norman Huebert,
  4. Gary W. Caldwell,
  5. Yanming Du and
  6. Hua Zhong
  1. Division of Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring House, Pennsylvania
  1. Address correspondence to:
    Zhengyin Yan, Drug Discovery, R2013, John-son & Johnson Pharmaceutical Research & Development, LLC, Welsh & McKean Roads, Spring House, PA 19477-0779. E-mail: zyan{at}prdus.jnj.com
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Research ArticleArticle

DETECTION OF A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES

Zhengyin Yan, Jian Li, Norman Huebert, Gary W. Caldwell, Yanming Du and Hua Zhong
Drug Metabolism and Disposition June 1, 2005, 33 (6) 706-713; DOI: https://doi.org/10.1124/dmd.104.003095
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