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IMPACT OF PARALLEL PATHWAYS OF DRUG ELIMINATION AND MULTIPLE CYTOCHROME P450 INVOLVEMENT ON DRUG-DRUG INTERACTIONS: CYP2D6 PARADIGM

Kiyomi Ito, David Hallifax, R. Scott Obach and J. Brian Houston
Drug Metabolism and Disposition June 2005, 33 (6) 837-844; DOI: https://doi.org/10.1124/dmd.105.003715

Article Information

vol. 33 no. 6 837-844
DOI 
https://doi.org/10.1124/dmd.105.003715
PubMed 
15897600
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 14, 2005
  • Accepted March 9, 2005
  • Published online May 16, 2005.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kiyomi Ito,
  2. David Hallifax,
  3. R. Scott Obach and
  4. J. Brian Houston
  1. School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (K.I., D.H., J.B.H.); and Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Pfizer Global Research and Development, Groton, Connecticut (R.S.O.)
  1. Address correspondence to:
    Professor J. Brian Houston, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK. E-mail: Brian.Houston{at}manchester.ac.uk
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Research ArticleArticle

IMPACT OF PARALLEL PATHWAYS OF DRUG ELIMINATION AND MULTIPLE CYTOCHROME P450 INVOLVEMENT ON DRUG-DRUG INTERACTIONS: CYP2D6 PARADIGM

Kiyomi Ito, David Hallifax, R. Scott Obach and J. Brian Houston
Drug Metabolism and Disposition June 1, 2005, 33 (6) 837-844; DOI: https://doi.org/10.1124/dmd.105.003715
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