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Research ArticleArticle

IN VITRO-IN VIVO EXTRAPOLATION OF CYP2D6 INACTIVATION BY PAROXETINE: PREDICTION OF NONSTATIONARY PHARMACOKINETICS AND DRUG INTERACTION MAGNITUDE

Karthik Venkatakrishnan and R. Scott Obach
Drug Metabolism and Disposition June 2005, 33 (6) 845-852; DOI: https://doi.org/10.1124/dmd.105.004077
Karthik Venkatakrishnan
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R. Scott Obach
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Article Information

vol. 33 no. 6 845-852
DOI 
https://doi.org/10.1124/dmd.105.004077
PubMed 
15788540

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 7, 2005
  • Accepted March 17, 2005
  • Published online May 16, 2005.

Article Versions

  • Earlier version (March 23, 2005 - 08:42).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Karthik Venkatakrishnan and
  2. R. Scott Obach
  1. Departments of Clinical Pharmacokinetics and Pharmacodynamics (K.V.), and Pharmacokinetics, Dynamics and Metabolism (R.S.O.), Pfizer Global Research and Development, Groton, Connecticut
  1. Address correspondence to:
    Dr. Karthik Venkatakrishnan, Clinical Pharmacokinetics and Pharmacodynamics, Pfizer Global Research and Development, Groton, CT 06340. E-mail: karthik.venkatakrishnan{at}pfizer.com
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Drug Metabolism and Disposition: 33 (6)
Drug Metabolism and Disposition
Vol. 33, Issue 6
1 Jun 2005
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Research ArticleArticle

IN VITRO-IN VIVO EXTRAPOLATION OF CYP2D6 INACTIVATION BY PAROXETINE: PREDICTION OF NONSTATIONARY PHARMACOKINETICS AND DRUG INTERACTION MAGNITUDE

Karthik Venkatakrishnan and R. Scott Obach
Drug Metabolism and Disposition June 1, 2005, 33 (6) 845-852; DOI: https://doi.org/10.1124/dmd.105.004077

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Research ArticleArticle

IN VITRO-IN VIVO EXTRAPOLATION OF CYP2D6 INACTIVATION BY PAROXETINE: PREDICTION OF NONSTATIONARY PHARMACOKINETICS AND DRUG INTERACTION MAGNITUDE

Karthik Venkatakrishnan and R. Scott Obach
Drug Metabolism and Disposition June 1, 2005, 33 (6) 845-852; DOI: https://doi.org/10.1124/dmd.105.004077
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