IN VITRO-IN VIVO EXTRAPOLATION OF CYP2D6 INACTIVATION BY PAROXETINE: PREDICTION OF NONSTATIONARY PHARMACOKINETICS AND DRUG INTERACTION MAGNITUDE

Departments of Clinical Pharmacokinetics and Pharmacodynamics (K.V.), and Pharmacokinetics, Dynamics and Metabolism (R.S.O.), Pfizer Global Research and Development, Groton, Connecticut

Address correspondence to:
Dr. Karthik Venkatakrishnan, Clinical Pharmacokinetics and Pharmacodynamics, Pfizer Global Research and Development, Groton, CT 06340. E-mail: karthik.venkatakrishnan{at}pfizer.com

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	Abstract	Full	Pdf
Mar 2005	38	0	66
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May 2005	121	65	211
Jun 2005	59	112	110
Jul 2005	54	74	71
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Jan 2011	18	13	9
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Jan 2012	39	33	27
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Jan 2013	40	41	33
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Jul 2017	4	21	12
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Nov 2017	7	39	20
Dec 2017	1	25	15
Jan 2018	1	17	6
Feb 2018	2	24	8
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Apr 2018	0	31	7
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Jul 2018	0	31	15
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Jan 2019	91	1	11
Feb 2019	72	1	8
Mar 2019	23	3	4
Apr 2019	33	6	7
May 2019	17	3	4
Jun 2019	11	1	19
Jul 2019	39	7	5
Aug 2019	47	6	7
Sep 2019	42	11	5
Oct 2019	22	2	6
Nov 2019	23	3	3
Dec 2019	35	9	3
Jan 2020	10	2	2
Feb 2020	31	7	6
Mar 2020	29	8	4
Apr 2020	29	5	13
May 2020	14	9	5
Jun 2020	55	6	1
Jul 2020	34	3	5
Aug 2020	16	3	7
Sep 2020	26	8	4
Oct 2020	29	10	16
Nov 2020	23	9	14
Dec 2020	15	8	9
Jan 2021	34	29	9
Feb 2021	43	22	8
Mar 2021	18	4	3
Apr 2021	42	6	10
May 2021	56	14	6
Jun 2021	13	10	3
Jul 2021	17	6	4
Aug 2021	19	20	4
Sep 2021	13	11	2