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IN VITRO-IN VIVO EXTRAPOLATION OF CYP2D6 INACTIVATION BY PAROXETINE: PREDICTION OF NONSTATIONARY PHARMACOKINETICS AND DRUG INTERACTION MAGNITUDE

Karthik Venkatakrishnan and R. Scott Obach
Drug Metabolism and Disposition June 2005, 33 (6) 845-852; DOI: https://doi.org/10.1124/dmd.105.004077

Article Information

vol. 33 no. 6 845-852
DOI 
https://doi.org/10.1124/dmd.105.004077
PubMed 
15788540
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 7, 2005
  • Accepted March 17, 2005
  • Published online May 16, 2005.

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The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Karthik Venkatakrishnan and
  2. R. Scott Obach
  1. Departments of Clinical Pharmacokinetics and Pharmacodynamics (K.V.), and Pharmacokinetics, Dynamics and Metabolism (R.S.O.), Pfizer Global Research and Development, Groton, Connecticut
  1. Address correspondence to:
    Dr. Karthik Venkatakrishnan, Clinical Pharmacokinetics and Pharmacodynamics, Pfizer Global Research and Development, Groton, CT 06340. E-mail: karthik.venkatakrishnan{at}pfizer.com
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Research ArticleArticle

IN VITRO-IN VIVO EXTRAPOLATION OF CYP2D6 INACTIVATION BY PAROXETINE: PREDICTION OF NONSTATIONARY PHARMACOKINETICS AND DRUG INTERACTION MAGNITUDE

Karthik Venkatakrishnan and R. Scott Obach
Drug Metabolism and Disposition June 1, 2005, 33 (6) 845-852; DOI: https://doi.org/10.1124/dmd.105.004077
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