IN VITRO-IN VIVO EXTRAPOLATION OF CYP2D6 INACTIVATION BY PAROXETINE: PREDICTION OF NONSTATIONARY PHARMACOKINETICS AND DRUG INTERACTION MAGNITUDE

Departments of Clinical Pharmacokinetics and Pharmacodynamics (K.V.), and Pharmacokinetics, Dynamics and Metabolism (R.S.O.), Pfizer Global Research and Development, Groton, Connecticut

Address correspondence to:
Dr. Karthik Venkatakrishnan, Clinical Pharmacokinetics and Pharmacodynamics, Pfizer Global Research and Development, Groton, CT 06340. E-mail: karthik.venkatakrishnan{at}pfizer.com

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: March 2005 to January 2021

	Abstract	Full	Pdf
Mar 2005	38	0	66
Apr 2005	34	0	96
May 2005	121	65	211
Jun 2005	59	112	110
Jul 2005	54	74	71
Aug 2005	25	56	54
Sep 2005	22	97	56
Oct 2005	26	58	35
Nov 2005	49	68	30
Dec 2005	21	67	53
Jan 2006	45	35	46
Feb 2006	23	20	21
Mar 2006	20	29	27
Apr 2006	10	20	24
May 2006	14	30	22
Jun 2006	15	50	48
Jul 2006	10	43	41
Aug 2006	12	45	33
Sep 2006	19	35	38
Oct 2006	22	72	48
Nov 2006	19	56	47
Dec 2006	14	41	33
Jan 2007	20	45	35
Feb 2007	17	40	36
Mar 2007	17	44	45
Apr 2007	13	37	31
May 2007	18	41	44
Jun 2007	15	44	56
Jul 2007	14	56	43
Aug 2007	14	33	41
Sep 2007	12	32	31
Oct 2007	15	44	39
Nov 2007	16	27	29
Dec 2007	7	20	20
Jan 2008	13	34	35
Feb 2008	11	26	23
Mar 2008	17	35	38
Apr 2008	16	37	35
May 2008	29	42	27
Jun 2008	15	49	35
Jul 2008	21	54	36
Aug 2008	16	37	20
Sep 2008	25	32	31
Oct 2008	23	40	27
Nov 2008	12	19	16
Dec 2008	7	10	8
Jan 2009	14	16	31
Feb 2009	11	19	22
Mar 2009	22	25	27
Apr 2009	5	25	32
May 2009	8	27	27
Jun 2009	9	25	19
Jul 2009	19	23	20
Aug 2009	10	15	19
Sep 2009	14	18	20
Oct 2009	21	22	23
Nov 2009	19	18	23
Dec 2009	22	7	14
Jan 2010	42	15	25
Feb 2010	35	19	29
Mar 2010	43	37	31
Apr 2010	30	36	21
May 2010	24	15	18
Jun 2010	31	20	24
Jul 2010	43	25	23
Aug 2010	24	19	19
Sep 2010	22	24	14
Oct 2010	18	29	20
Nov 2010	25	28	13
Dec 2010	20	19	12
Jan 2011	18	13	9
Feb 2011	25	23	21
Mar 2011	25	18	19
Apr 2011	22	29	27
May 2011	15	24	23
Jun 2011	25	17	13
Jul 2011	27	26	28
Aug 2011	27	39	25
Sep 2011	39	33	18
Oct 2011	39	27	20
Nov 2011	33	36	22
Dec 2011	36	27	27
Jan 2012	39	33	27
Feb 2012	47	32	24
Mar 2012	45	21	29
Apr 2012	19	28	32
May 2012	27	34	27
Jun 2012	22	24	32
Jul 2012	31	20	36
Aug 2012	29	25	34
Sep 2012	24	19	26
Oct 2012	20	21	29
Nov 2012	35	36	46
Dec 2012	30	16	22
Jan 2013	40	41	33
Feb 2013	31	34	33
Mar 2013	24	30	40
Apr 2013	32	34	38
May 2013	43	33	28
Jun 2013	22	21	14
Jul 2013	23	25	22
Aug 2013	17	26	17
Sep 2013	35	20	18
Oct 2013	37	25	33
Nov 2013	22	23	15
Dec 2013	28	21	15
Jan 2014	23	36	22
Feb 2014	18	26	21
Mar 2014	45	56	27
Apr 2014	23	49	25
May 2014	23	43	23
Jun 2014	8	24	10
Jul 2014	24	29	29
Aug 2014	14	18	8
Sep 2014	32	26	33
Oct 2014	40	14	11
Nov 2014	13	20	11
Dec 2014	7	17	6
Jan 2015	21	17	16
Feb 2015	9	24	13
Mar 2015	18	22	16
Apr 2015	22	19	12
May 2015	16	21	10
Jun 2015	24	14	13
Jul 2015	9	25	15
Aug 2015	12	26	15
Sep 2015	10	19	20
Oct 2015	21	17	12
Nov 2015	18	11	11
Dec 2015	21	44	14
Jan 2016	24	18	21
Feb 2016	17	16	15
Mar 2016	3	18	26
Apr 2016	15	22	18
May 2016	25	17	20
Jun 2016	31	22	23
Jul 2016	12	18	26
Aug 2016	9	13	12
Sep 2016	8	21	24
Oct 2016	6	28	7
Nov 2016	15	30	16
Dec 2016	5	20	12
Jan 2017	0	29	23
Feb 2017	2	32	26
Mar 2017	2	17	19
Apr 2017	5	28	18
May 2017	4	24	13
Jun 2017	1	16	12
Jul 2017	4	21	12
Aug 2017	2	34	10
Sep 2017	0	31	14
Oct 2017	0	35	41
Nov 2017	7	39	20
Dec 2017	1	25	15
Jan 2018	1	17	6
Feb 2018	2	24	8
Mar 2018	1	30	13
Apr 2018	0	31	7
May 2018	1	24	7
Jun 2018	1	30	13
Jul 2018	0	31	15
Aug 2018	0	26	31
Sep 2018	0	23	2
Oct 2018	0	76	13
Nov 2018	0	88	17
Dec 2018	99	26	11
Jan 2019	91	1	11
Feb 2019	72	1	8
Mar 2019	23	3	4
Apr 2019	33	6	7
May 2019	17	3	4
Jun 2019	11	1	19
Jul 2019	39	7	5
Aug 2019	47	6	7
Sep 2019	42	11	5
Oct 2019	22	2	6
Nov 2019	23	3	3
Dec 2019	35	9	3
Jan 2020	10	2	2
Feb 2020	31	7	6
Mar 2020	29	8	4
Apr 2020	29	5	13
May 2020	14	9	5
Jun 2020	55	6	1
Jul 2020	34	3	5
Aug 2020	16	3	7
Sep 2020	26	8	4
Oct 2020	29	10	16
Nov 2020	23	9	14
Dec 2020	15	8	9
Jan 2021	27	25	7