Table of Contents

Articles

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  VARIABLE EXPRESSION OF MRP2 (ABCC2) IN HUMAN PLACENTA: INFLUENCE OF GESTATIONAL AGE AND CELLULAR DIFFERENTIATION

  Henriette E. Meyer zu Schwabedissen, Gabriele Jedlitschky, Matthias Gratz, Sierk Haenisch, Knud Linnemann, Christoph Fusch, Ingolf Cascorbi and Heyo K. Kroemer

  Drug Metabolism and Disposition July 2005, 33 (7) 896-904; DOI: https://doi.org/10.1124/dmd.104.003335
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  REGULATION OF THE CELL SURFACE EXPRESSION OF HUMAN BCRP/ABCG2 BY THE PHOSPHORYLATION STATE OF AKT IN POLARIZED CELLS

  Tappei Takada, Hiroshi Suzuki, Yukiko Gotoh and Yuichi Sugiyama

  Drug Metabolism and Disposition July 2005, 33 (7) 905-909; DOI: https://doi.org/10.1124/dmd.104.003228
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  POSSIBLE PATHWAY(S) OF TESTOSTERONE EGRESS FROM THE ACTIVE SITE OF CYTOCHROME P450 2B1: A STEERED MOLECULAR DYNAMICS SIMULATION

  Weihua Li, Hong Liu, Emily E. Scott, Frauke Gräter, James R. Halpert, Xiaoming Luo, Jianhua Shen and Hualiang Jiang

  Drug Metabolism and Disposition July 2005, 33 (7) 910-919; DOI: https://doi.org/10.1124/dmd.105.004200
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  THE USE OF A SUBSTRATE CASSETTE STRATEGY TO IMPROVE THE CAPACITY AND THROUGHPUT OF CYTOCHROME P450 INDUCTION STUDIES IN HUMAN HEPATOCYTES

  Michael A. Mohutsky, David M. Petullo and Steven A. Wrighton

  Drug Metabolism and Disposition July 2005, 33 (7) 920-923; DOI: https://doi.org/10.1124/dmd.105.004291
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  IDENTIFICATION OF HMG-CoA REDUCTASE INHIBITORS AS ACTIVATORS FOR HUMAN, MOUSE AND RAT CONSTITUTIVE ANDROSTANE RECEPTOR

  Kaoru Kobayashi, Yosuke Yamanaka, Norihiko Iwazaki, Ikumi Nakajo, Masakiyo Hosokawa, Masahiko Negishi and Kan Chiba

  Drug Metabolism and Disposition July 2005, 33 (7) 924-929; DOI: https://doi.org/10.1124/dmd.104.002741
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  METABOLIC PROFILE OF 1,5-DICAFFEOYLQUINIC ACID IN RATS, AN IN VIVO AND IN VITRO STUDY

  Bo Yang, Zhiyun Meng, Junxing Dong, Liangping Yan, Libo Zou, Zhongming Tang and Guifang Dou

  Drug Metabolism and Disposition July 2005, 33 (7) 930-936; DOI: https://doi.org/10.1124/dmd.104.002154
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  LITHOCHOLIC ACID DECREASES EXPRESSION OF UGT2B7 IN CACO-2 CELLS: A POTENTIAL ROLE FOR A NEGATIVE FARNESOID X RECEPTOR RESPONSE ELEMENT

  Yuan Lu, Jean-Marie Heydel, Xin Li, Stacie Bratton, Tim Lindblom and Anna Radominska-Pandya

  Drug Metabolism and Disposition July 2005, 33 (7) 937-946; DOI: https://doi.org/10.1124/dmd.104.003061
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  TISSUE DISTRIBUTION AND HEPATIC AND RENAL ONTOGENY OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) FAMILY IN MICE

  Jonathan M. Maher, Angela L. Slitt, Nathan J. Cherrington, Xingguo Cheng and Curtis D. Klaassen

  Drug Metabolism and Disposition July 2005, 33 (7) 947-955; DOI: https://doi.org/10.1124/dmd.105.003780
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  INDUCTION OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN FAMILY OF TRANSPORTERS BY CHEMICAL ACTIVATORS OF RECEPTOR-MEDIATED PATHWAYS IN MOUSE LIVER

  Jonathan M. Maher, Xingguo Cheng, Angela L. Slitt, Matthew Z. Dieter and Curtis D. Klaassen

  Drug Metabolism and Disposition July 2005, 33 (7) 956-962; DOI: https://doi.org/10.1124/dmd.105.003798
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  P-GLYCOPROTEIN PLAYS A MAJOR ROLE IN THE EFFLUX OF FEXOFENADINE IN THE SMALL INTESTINE AND BLOOD-BRAIN BARRIER, BUT ONLY A LIMITED ROLE IN ITS BILIARY EXCRETION

  Harunobu Tahara, Hiroyuki Kusuhara, Eiichi Fuse and Yuichi Sugiyama

  Drug Metabolism and Disposition July 2005, 33 (7) 963-968; DOI: https://doi.org/10.1124/dmd.105.004192
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  IDENTIFICATION OF CYTOCHROME P450 AND ARYLAMINE N-ACETYLTRANSFERASE ISOFORMS INVOLVED IN SULFADIAZINE METABOLISM

  Helen R. Winter and Jashvant D. Unadkat

  Drug Metabolism and Disposition July 2005, 33 (7) 969-976; DOI: https://doi.org/10.1124/dmd.104.002998
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  DIFFERENTIAL RATES OF GLUCURONIDATION FOR 7-ETHYL-10-HYDROXY-CAMPTOTHECIN (SN-38) LACTONE AND CARBOXYLATE IN HUMAN AND RAT MICROSOMES AND RECOMBINANT UDP-GLUCURONOSYLTRANSFERASE ISOFORMS

  Melanie N. Tallman, Joseph K. Ritter and Philip C. Smith

  Drug Metabolism and Disposition July 2005, 33 (7) 977-983; DOI: https://doi.org/10.1124/dmd.104.003491
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  SYNTHESIS AND CHARACTERIZATION OF SOME NEW PHASE II METABOLITES OF THE ALKYLATOR BENDAMUSTINE AND THEIR IDENTIFICATION IN HUMAN BILE, URINE, AND PLASMA FROM PATIENTS WITH CHOLANGIOCARCINOMA

  Jens Teichert, Reinhard Sohr, Frank Baumann, Lothar Hennig, Karlheinz Merkle, Karel Caca and Rainer Preiss

  Drug Metabolism and Disposition July 2005, 33 (7) 984-992; DOI: https://doi.org/10.1124/dmd.105.003624
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  ARSENITE DECREASES CYP3A4 AND RXRα IN PRIMARY HUMAN HEPATOCYTES

  Trisha L. Noreault, Vsevolod E. Kostrubsky, Sheryl G. Wood, Ralph C. Nichols, Stephen C. Strom, Heidi W. Trask, Steven A. Wrighton, Ronald M. Evans, Judith M. Jacobs, Peter R. Sinclair and Jacqueline F. Sinclair

  Drug Metabolism and Disposition July 2005, 33 (7) 993-1003; DOI: https://doi.org/10.1124/dmd.105.003954
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  EXPRESSION AND INDUCTION POTENTIAL OF CYTOCHROMES P450 IN HUMAN CRYOPRESERVED HEPATOCYTES

  Dirk Roymans, Pieter Annaert, Jos Van Houdt, Adri Weygers, Jan Noukens, Carlo Sensenhauser, José Silva, Cis Van Looveren, Jan Hendrickx, Geert Mannens and Willem Meuldermans

  Drug Metabolism and Disposition July 2005, 33 (7) 1004-1016; DOI: https://doi.org/10.1124/dmd.104.003046
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  KINETIC CHARACTERIZATION OF THE 1A SUBFAMILY OF RECOMBINANT HUMAN UDP-GLUCURONOSYLTRANSFERASES

  Leena Luukkanen, Jyrki Taskinen, Mika Kurkela, Risto Kostiainen, Jouni Hirvonen and Moshe Finel

  Drug Metabolism and Disposition July 2005, 33 (7) 1017-1026; DOI: https://doi.org/10.1124/dmd.105.004093
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  GLUCURONIDATION OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS: IDENTIFYING THE ENZYMES RESPONSIBLE IN HUMAN LIVER MICROSOMES

  Gwendolyn E. Kuehl, Johanna W. Lampe, John D. Potter and Jeannette Bigler

  Drug Metabolism and Disposition July 2005, 33 (7) 1027-1035; DOI: https://doi.org/10.1124/dmd.104.002527
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  DISPOSITION AND METABOLISM OF [2-¹⁴C]QUERCETIN-4′-GLUCOSIDE IN RATS

  Brigitte A. Graf, William Mullen, Stuart T. Caldwell, Richard C. Hartley, Garry G. Duthie, Michael E. J. Lean, Alan Crozier and Christine A. Edwards

  Drug Metabolism and Disposition July 2005, 33 (7) 1036-1043; DOI: https://doi.org/10.1124/dmd.104.002691
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  INDUCTION OF CYP1A IN THE BEAGLE DOG BY AN INHIBITOR OF KINASE INSERT DOMAIN-CONTAINING RECEPTOR: DIFFERENTIAL EFFECTS IN VITRO AND IN VIVO ON MRNA AND FUNCTIONAL ACTIVITY

  Christopher R. Gibson, Charles Lin, Rominder Singh, Cheri M. Brown, Karen Richards, Janice Brunner, Kimberly Michel, Jennifer Adelsberger, Edward Carlini, Catherine Boothe-Genthe, Conrad Raab, Minh Luu, Aimee Michael, Mona Parikh, Patrice Ciecko, Raju Subramanian, Paul Krolikowski, A. David Rodrigues, Thomas A. Baillie and Thomas H. Rushmore

  Drug Metabolism and Disposition July 2005, 33 (7) 1044-1051; DOI: https://doi.org/10.1124/dmd.105.003913
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  DEXTROMETHORPHAN TO DEXTRORPHAN URINARY METABOLIC RATIO DOES NOT REFLECT DEXTROMETHORPHAN ORAL CLEARANCE

  Silvana Borges, Lang Li, Mitchell A. Hamman, David R. Jones, Stephen D. Hall and J. Christopher Gorski

  Drug Metabolism and Disposition July 2005, 33 (7) 1052-1055; DOI: https://doi.org/10.1124/dmd.104.003459
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  MONOCLONAL NICOTINE-SPECIFIC ANTIBODIES REDUCE NICOTINE DISTRIBUTION TO BRAIN IN RATS: DOSE- AND AFFINITY-RESPONSE RELATIONSHIPS

  D. E. Keyler, S. A. Roiko, E. Benlhabib, M. G. LeSage, J. V. St. Peter, S. Stewart, S. Fuller, C. T. Le and P. R. Pentel

  Drug Metabolism and Disposition July 2005, 33 (7) 1056-1061; DOI: https://doi.org/10.1124/dmd.105.004234
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  TISSUE DISTRIBUTION AND ONTOGENY OF MOUSE ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPS)

  Xingguo Cheng, Jonathan Maher, Chuan Chen and Curtis D. Klaassen

  Drug Metabolism and Disposition July 2005, 33 (7) 1062-1073; DOI: https://doi.org/10.1124/dmd.105.003640
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  CONTRIBUTION OF CYP3A5 TO HEPATIC AND RENAL IFOSFAMIDE N-DECHLOROETHYLATION

  Jeannine S. McCune, Linda J. Risler, Brian R. Phillips, Kenneth E. Thummel, David Blough and Danny D. Shen

  Drug Metabolism and Disposition July 2005, 33 (7) 1074-1081; DOI: https://doi.org/10.1124/dmd.104.002279