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Drug Metabolism & Disposition

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Table of Contents

July 01, 2005; Volume 33,Issue 7

MINIREVIEWS

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    THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS OF CYTOCHROMES P450: EFFECT OF INCORPORATING HIGHER-AFFINITY LIGANDS AND POTENTIAL NEW APPLICATIONS
    Charles W. Locuson and Jan L. Wahlstrom
    Drug Metabolism and Disposition July 2005, 33 (7) 873-878; DOI: https://doi.org/10.1124/dmd.105.004325

Short Communications

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    CHARACTERIZATION OF A NOVEL METABOLITE INTERMEDIATE OF ZIPRASIDONE IN HEPATIC CYTOSOLIC FRACTIONS OF RAT, DOG, AND HUMAN BY ESI-MS/MS, HYDROGEN/DEUTERIUM EXCHANGE, AND CHEMICAL DERIVATIZATION
    Zhuang Miao, Amin Kamel and Chandra Prakash
    Drug Metabolism and Disposition July 2005, 33 (7) 879-883; DOI: https://doi.org/10.1124/dmd.105.004036
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    CYP3A5 GENETIC POLYMORPHISMS IN DIFFERENT ETHNIC POPULATIONS
    Jean-Nicholas Roy, Julie Lajoie, Lynn S. Zijenah, Azemi Barama, Charles Poirier, Brian J. Ward and Michel Roger
    Drug Metabolism and Disposition July 2005, 33 (7) 884-887; DOI: https://doi.org/10.1124/dmd.105.003822
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    PREVENTION OF MRP2 ACTIVITY IMPAIRMENT IN ETHINYLESTRADIOL-INDUCED CHOLESTASIS BY URSODEOXYCHOLATE IN THE RAT
    Fernando A. Crocenzi, Vanesa D'Andrea, Viviana A. Catania, Marcelo G. Luquita, José M. Pellegrino, J. Elena Ochoa, Aldo D. Mottino and Enrique J. Sánchez Pozzi
    Drug Metabolism and Disposition July 2005, 33 (7) 888-891; DOI: https://doi.org/10.1124/dmd.104.003533
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    MIDAZOLAM AND CYCLOSPORIN A METABOLISM IN TRANSGENIC MICE WITH LIVER-SPECIFIC EXPRESSION OF HUMAN CYP3A4
    Antonius E. van Herwaarden, Johan W. Smit, Rolf W. Sparidans, Els Wagenaar, Cornelia M. M. van der Kruijssen, Jan H. M. Schellens, Jos H. Beijnen and Alfred H. Schinkel
    Drug Metabolism and Disposition July 2005, 33 (7) 892-895; DOI: https://doi.org/10.1124/dmd.105.004721

Articles

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    VARIABLE EXPRESSION OF MRP2 (ABCC2) IN HUMAN PLACENTA: INFLUENCE OF GESTATIONAL AGE AND CELLULAR DIFFERENTIATION
    Henriette E. Meyer zu Schwabedissen, Gabriele Jedlitschky, Matthias Gratz, Sierk Haenisch, Knud Linnemann, Christoph Fusch, Ingolf Cascorbi and Heyo K. Kroemer
    Drug Metabolism and Disposition July 2005, 33 (7) 896-904; DOI: https://doi.org/10.1124/dmd.104.003335
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    REGULATION OF THE CELL SURFACE EXPRESSION OF HUMAN BCRP/ABCG2 BY THE PHOSPHORYLATION STATE OF AKT IN POLARIZED CELLS
    Tappei Takada, Hiroshi Suzuki, Yukiko Gotoh and Yuichi Sugiyama
    Drug Metabolism and Disposition July 2005, 33 (7) 905-909; DOI: https://doi.org/10.1124/dmd.104.003228
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    POSSIBLE PATHWAY(S) OF TESTOSTERONE EGRESS FROM THE ACTIVE SITE OF CYTOCHROME P450 2B1: A STEERED MOLECULAR DYNAMICS SIMULATION
    Weihua Li, Hong Liu, Emily E. Scott, Frauke Gräter, James R. Halpert, Xiaoming Luo, Jianhua Shen and Hualiang Jiang
    Drug Metabolism and Disposition July 2005, 33 (7) 910-919; DOI: https://doi.org/10.1124/dmd.105.004200
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    THE USE OF A SUBSTRATE CASSETTE STRATEGY TO IMPROVE THE CAPACITY AND THROUGHPUT OF CYTOCHROME P450 INDUCTION STUDIES IN HUMAN HEPATOCYTES
    Michael A. Mohutsky, David M. Petullo and Steven A. Wrighton
    Drug Metabolism and Disposition July 2005, 33 (7) 920-923; DOI: https://doi.org/10.1124/dmd.105.004291
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    IDENTIFICATION OF HMG-CoA REDUCTASE INHIBITORS AS ACTIVATORS FOR HUMAN, MOUSE AND RAT CONSTITUTIVE ANDROSTANE RECEPTOR
    Kaoru Kobayashi, Yosuke Yamanaka, Norihiko Iwazaki, Ikumi Nakajo, Masakiyo Hosokawa, Masahiko Negishi and Kan Chiba
    Drug Metabolism and Disposition July 2005, 33 (7) 924-929; DOI: https://doi.org/10.1124/dmd.104.002741
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    METABOLIC PROFILE OF 1,5-DICAFFEOYLQUINIC ACID IN RATS, AN IN VIVO AND IN VITRO STUDY
    Bo Yang, Zhiyun Meng, Junxing Dong, Liangping Yan, Libo Zou, Zhongming Tang and Guifang Dou
    Drug Metabolism and Disposition July 2005, 33 (7) 930-936; DOI: https://doi.org/10.1124/dmd.104.002154
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    LITHOCHOLIC ACID DECREASES EXPRESSION OF UGT2B7 IN CACO-2 CELLS: A POTENTIAL ROLE FOR A NEGATIVE FARNESOID X RECEPTOR RESPONSE ELEMENT
    Yuan Lu, Jean-Marie Heydel, Xin Li, Stacie Bratton, Tim Lindblom and Anna Radominska-Pandya
    Drug Metabolism and Disposition July 2005, 33 (7) 937-946; DOI: https://doi.org/10.1124/dmd.104.003061
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    TISSUE DISTRIBUTION AND HEPATIC AND RENAL ONTOGENY OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) FAMILY IN MICE
    Jonathan M. Maher, Angela L. Slitt, Nathan J. Cherrington, Xingguo Cheng and Curtis D. Klaassen
    Drug Metabolism and Disposition July 2005, 33 (7) 947-955; DOI: https://doi.org/10.1124/dmd.105.003780
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    INDUCTION OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN FAMILY OF TRANSPORTERS BY CHEMICAL ACTIVATORS OF RECEPTOR-MEDIATED PATHWAYS IN MOUSE LIVER
    Jonathan M. Maher, Xingguo Cheng, Angela L. Slitt, Matthew Z. Dieter and Curtis D. Klaassen
    Drug Metabolism and Disposition July 2005, 33 (7) 956-962; DOI: https://doi.org/10.1124/dmd.105.003798
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    P-GLYCOPROTEIN PLAYS A MAJOR ROLE IN THE EFFLUX OF FEXOFENADINE IN THE SMALL INTESTINE AND BLOOD-BRAIN BARRIER, BUT ONLY A LIMITED ROLE IN ITS BILIARY EXCRETION
    Harunobu Tahara, Hiroyuki Kusuhara, Eiichi Fuse and Yuichi Sugiyama
    Drug Metabolism and Disposition July 2005, 33 (7) 963-968; DOI: https://doi.org/10.1124/dmd.105.004192
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    IDENTIFICATION OF CYTOCHROME P450 AND ARYLAMINE N-ACETYLTRANSFERASE ISOFORMS INVOLVED IN SULFADIAZINE METABOLISM
    Helen R. Winter and Jashvant D. Unadkat
    Drug Metabolism and Disposition July 2005, 33 (7) 969-976; DOI: https://doi.org/10.1124/dmd.104.002998
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    DIFFERENTIAL RATES OF GLUCURONIDATION FOR 7-ETHYL-10-HYDROXY-CAMPTOTHECIN (SN-38) LACTONE AND CARBOXYLATE IN HUMAN AND RAT MICROSOMES AND RECOMBINANT UDP-GLUCURONOSYLTRANSFERASE ISOFORMS
    Melanie N. Tallman, Joseph K. Ritter and Philip C. Smith
    Drug Metabolism and Disposition July 2005, 33 (7) 977-983; DOI: https://doi.org/10.1124/dmd.104.003491
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    SYNTHESIS AND CHARACTERIZATION OF SOME NEW PHASE II METABOLITES OF THE ALKYLATOR BENDAMUSTINE AND THEIR IDENTIFICATION IN HUMAN BILE, URINE, AND PLASMA FROM PATIENTS WITH CHOLANGIOCARCINOMA
    Jens Teichert, Reinhard Sohr, Frank Baumann, Lothar Hennig, Karlheinz Merkle, Karel Caca and Rainer Preiss
    Drug Metabolism and Disposition July 2005, 33 (7) 984-992; DOI: https://doi.org/10.1124/dmd.105.003624
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    ARSENITE DECREASES CYP3A4 AND RXRα IN PRIMARY HUMAN HEPATOCYTES
    Trisha L. Noreault, Vsevolod E. Kostrubsky, Sheryl G. Wood, Ralph C. Nichols, Stephen C. Strom, Heidi W. Trask, Steven A. Wrighton, Ronald M. Evans, Judith M. Jacobs, Peter R. Sinclair and Jacqueline F. Sinclair
    Drug Metabolism and Disposition July 2005, 33 (7) 993-1003; DOI: https://doi.org/10.1124/dmd.105.003954
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    EXPRESSION AND INDUCTION POTENTIAL OF CYTOCHROMES P450 IN HUMAN CRYOPRESERVED HEPATOCYTES
    Dirk Roymans, Pieter Annaert, Jos Van Houdt, Adri Weygers, Jan Noukens, Carlo Sensenhauser, José Silva, Cis Van Looveren, Jan Hendrickx, Geert Mannens and Willem Meuldermans
    Drug Metabolism and Disposition July 2005, 33 (7) 1004-1016; DOI: https://doi.org/10.1124/dmd.104.003046
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    KINETIC CHARACTERIZATION OF THE 1A SUBFAMILY OF RECOMBINANT HUMAN UDP-GLUCURONOSYLTRANSFERASES
    Leena Luukkanen, Jyrki Taskinen, Mika Kurkela, Risto Kostiainen, Jouni Hirvonen and Moshe Finel
    Drug Metabolism and Disposition July 2005, 33 (7) 1017-1026; DOI: https://doi.org/10.1124/dmd.105.004093
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    GLUCURONIDATION OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS: IDENTIFYING THE ENZYMES RESPONSIBLE IN HUMAN LIVER MICROSOMES
    Gwendolyn E. Kuehl, Johanna W. Lampe, John D. Potter and Jeannette Bigler
    Drug Metabolism and Disposition July 2005, 33 (7) 1027-1035; DOI: https://doi.org/10.1124/dmd.104.002527
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    DISPOSITION AND METABOLISM OF [2-14C]QUERCETIN-4′-GLUCOSIDE IN RATS
    Brigitte A. Graf, William Mullen, Stuart T. Caldwell, Richard C. Hartley, Garry G. Duthie, Michael E. J. Lean, Alan Crozier and Christine A. Edwards
    Drug Metabolism and Disposition July 2005, 33 (7) 1036-1043; DOI: https://doi.org/10.1124/dmd.104.002691
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    INDUCTION OF CYP1A IN THE BEAGLE DOG BY AN INHIBITOR OF KINASE INSERT DOMAIN-CONTAINING RECEPTOR: DIFFERENTIAL EFFECTS IN VITRO AND IN VIVO ON MRNA AND FUNCTIONAL ACTIVITY
    Christopher R. Gibson, Charles Lin, Rominder Singh, Cheri M. Brown, Karen Richards, Janice Brunner, Kimberly Michel, Jennifer Adelsberger, Edward Carlini, Catherine Boothe-Genthe, Conrad Raab, Minh Luu, Aimee Michael, Mona Parikh, Patrice Ciecko, Raju Subramanian, Paul Krolikowski, A. David Rodrigues, Thomas A. Baillie and Thomas H. Rushmore
    Drug Metabolism and Disposition July 2005, 33 (7) 1044-1051; DOI: https://doi.org/10.1124/dmd.105.003913
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    DEXTROMETHORPHAN TO DEXTRORPHAN URINARY METABOLIC RATIO DOES NOT REFLECT DEXTROMETHORPHAN ORAL CLEARANCE
    Silvana Borges, Lang Li, Mitchell A. Hamman, David R. Jones, Stephen D. Hall and J. Christopher Gorski
    Drug Metabolism and Disposition July 2005, 33 (7) 1052-1055; DOI: https://doi.org/10.1124/dmd.104.003459
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    MONOCLONAL NICOTINE-SPECIFIC ANTIBODIES REDUCE NICOTINE DISTRIBUTION TO BRAIN IN RATS: DOSE- AND AFFINITY-RESPONSE RELATIONSHIPS
    D. E. Keyler, S. A. Roiko, E. Benlhabib, M. G. LeSage, J. V. St. Peter, S. Stewart, S. Fuller, C. T. Le and P. R. Pentel
    Drug Metabolism and Disposition July 2005, 33 (7) 1056-1061; DOI: https://doi.org/10.1124/dmd.105.004234
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    TISSUE DISTRIBUTION AND ONTOGENY OF MOUSE ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPS)
    Xingguo Cheng, Jonathan Maher, Chuan Chen and Curtis D. Klaassen
    Drug Metabolism and Disposition July 2005, 33 (7) 1062-1073; DOI: https://doi.org/10.1124/dmd.105.003640
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    CONTRIBUTION OF CYP3A5 TO HEPATIC AND RENAL IFOSFAMIDE N-DECHLOROETHYLATION
    Jeannine S. McCune, Linda J. Risler, Brian R. Phillips, Kenneth E. Thummel, David Blough and Danny D. Shen
    Drug Metabolism and Disposition July 2005, 33 (7) 1074-1081; DOI: https://doi.org/10.1124/dmd.104.002279
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Drug Metabolism and Disposition: 33 (7)
Drug Metabolism and Disposition
Vol. 33, Issue 7
1 Jul 2005
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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