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Research ArticleArticle

P-GLYCOPROTEIN PLAYS A MAJOR ROLE IN THE EFFLUX OF FEXOFENADINE IN THE SMALL INTESTINE AND BLOOD-BRAIN BARRIER, BUT ONLY A LIMITED ROLE IN ITS BILIARY EXCRETION

Harunobu Tahara, Hiroyuki Kusuhara, Eiichi Fuse and Yuichi Sugiyama
Drug Metabolism and Disposition July 2005, 33 (7) 963-968; DOI: https://doi.org/10.1124/dmd.105.004192

Article Information

vol. 33 no. 7 963-968
DOI 
https://doi.org/10.1124/dmd.105.004192
PubMed 
15821041
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 11, 2005
  • Accepted March 31, 2005
  • Published online June 16, 2005.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Harunobu Tahara,
  2. Hiroyuki Kusuhara,
  3. Eiichi Fuse and
  4. Yuichi Sugiyama
  1. Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan (H.T., H.K., Y.S.); and Pharmacokinetic Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan (H.T., E.F.)
  1. Address correspondence to:
    Dr. Yuichi Sugiyama, Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. E-mail: sugiyama{at}mol.f.u-tokyo.ac.jp
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Research ArticleArticle

P-GLYCOPROTEIN PLAYS A MAJOR ROLE IN THE EFFLUX OF FEXOFENADINE IN THE SMALL INTESTINE AND BLOOD-BRAIN BARRIER, BUT ONLY A LIMITED ROLE IN ITS BILIARY EXCRETION

Harunobu Tahara, Hiroyuki Kusuhara, Eiichi Fuse and Yuichi Sugiyama
Drug Metabolism and Disposition July 1, 2005, 33 (7) 963-968; DOI: https://doi.org/10.1124/dmd.105.004192
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