Drug Metabolism and Disposition: 33 (8)

August 01, 2005; Volume 33,Issue 8

Symposium Report

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CANCER CHEMOTHERAPY AND DRUG METABOLISM
David S. Riddick, Chunja Lee, Shairoz Ramji, Edwin C. Chinje, Rachel L. Cowen, Kaye J. Williams, Adam V. Patterson, Ian J. Stratford, Charles S. Morrow, Alan J. Townsend, Youssef Jounaidi, Chong-Sheng Chen, Ting Su, Hong Lu, Pamela S. Schwartz and David J. Waxman

Drug Metabolism and Disposition August 2005, 33 (8) 1083-1096; DOI: https://doi.org/10.1124/dmd.105.004374

Short Communication

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THE DIETARY POLYPHENOL ELLAGIC ACID IS A POTENT INHIBITOR OF hOAT1
Alexander C Whitley, Douglas H. Sweet and Thomas Walle

Drug Metabolism and Disposition August 2005, 33 (8) 1097-1100; DOI: https://doi.org/10.1124/dmd.105.004275

Articles

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TRANSENDOCARDIAL AND TRANSEPICARDIAL INTRAMYOCARDIAL FIBROBLAST GROWTH FACTOR-2 ADMINISTRATION: MYOCARDIAL AND TISSUE DISTRIBUTION
Roger J. Laham, Mark Post, Mehrdad Rezaee, Laurel Donnell-Fink, Joanna J. Wykrzykowska, Seung U. Lee, Donald S. Baim and Frank W. Sellke

Drug Metabolism and Disposition August 2005, 33 (8) 1101-1107; DOI: https://doi.org/10.1124/dmd.104.002774
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METABOLISM OF VERAPAMIL IN CULTURES OF RAT ALVEOLAR EPITHELIAL CELLS AND PHARMACOKINETICS AFTER ADMINISTRATION BY INTRAVENOUS AND INHALATION ROUTES
Jürgen Borlak, Maren Blickwede, Tanja Hansen, Wolfgang Koch, Markus Walles and Karsten Levsen

Drug Metabolism and Disposition August 2005, 33 (8) 1108-1114; DOI: https://doi.org/10.1124/dmd.105.003723
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METABOLISM OF THE α,β-UNSATURATED KETONES, CHALCONE AND TRANS-4-PHENYL-3-BUTEN-2-ONE, BY RAT LIVER MICROSOMES AND ESTROGENIC ACTIVITY OF THE METABOLITES
Yoichi Kohno, Shigeyuki Kitamura, Seigo Sanoh, Kazumi Sugihara, Nariaki Fujimoto and Shigeru Ohta

Drug Metabolism and Disposition August 2005, 33 (8) 1115-1123; DOI: https://doi.org/10.1124/dmd.104.002634
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BETAMETHASONE PHARMACOKINETICS AFTER TWO PRODRUG FORMULATIONS IN SHEEP: IMPLICATIONS FOR ANTENATAL CORTICOSTEROID USE
Mahesh N. Samtani, Matthias Lohle, Angela Grant, Peter W. Nathanielsz and William J. Jusko

Drug Metabolism and Disposition August 2005, 33 (8) 1124-1130; DOI: https://doi.org/10.1124/dmd.105.004309
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ROLE OF CYTOCHROME B₅ IN MODULATING PEROXIDE-SUPPORTED CYP3A4 ACTIVITY: EVIDENCE FOR A CONFORMATIONAL TRANSITION AND CYTOCHROME P450 HETEROGENEITY
Santosh Kumar, Dmitri R. Davydov and James R. Halpert

Drug Metabolism and Disposition August 2005, 33 (8) 1131-1136; DOI: https://doi.org/10.1124/dmd.105.004606
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NEUROPHARMACOKINETICS OF A NEW α-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) MODULATOR, S18986 [(S)-2,3-DIHYDRO-[3,4]CYCLOPENTANO-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE], IN THE RAT
Fanchon Bourasset, Katy Bernard, Carmen Muñoz, Patrick Genissel and Jean-Michel Scherrmann

Drug Metabolism and Disposition August 2005, 33 (8) 1137-1143; DOI: https://doi.org/10.1124/dmd.105.004424
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INCREASED BIOACCUMULATION OF URETHANE IN CYP2E1-/- VERSUS CYP2E1+/+ MICE
Undi Hoffler and Burhan I. Ghanayem

Drug Metabolism and Disposition August 2005, 33 (8) 1144-1150; DOI: https://doi.org/10.1124/dmd.105.003806
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FUNCTIONAL INVOLVEMENT OF RAT ORGANIC ANION TRANSPORTER 2 (SLC22A7) IN THE HEPATIC UPTAKE OF THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG KETOPROFEN
Naomi Morita, Hiroyuki Kusuhara, Yoshitane Nozaki, Hitoshi Endou and Yuichi Sugiyama

Drug Metabolism and Disposition August 2005, 33 (8) 1151-1157; DOI: https://doi.org/10.1124/dmd.104.001552
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MULTIPLE MECHANISMS ARE INVOLVED IN THE BILIARY EXCRETION OF ACETAMINOPHEN SULFATE IN THE RAT: ROLE OF MRP2 AND BCRP1
Maciej J. Zamek-Gliszczynski, Keith A. Hoffmaster, Xianbin Tian, Rong Zhao, Joseph W. Polli, Joan E. Humphreys, Lindsey O. Webster, Arlene S. Bridges, J. Cory Kalvass and Kim L. R. Brouwer

Drug Metabolism and Disposition August 2005, 33 (8) 1158-1165; DOI: https://doi.org/10.1124/dmd.104.002188
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NICOTINE 5′-OXIDATION AND METHYL OXIDATION BY P450 2A ENZYMES
Sharon E. Murphy, Vytautas Raulinaitis and Kathryn M. Brown

Drug Metabolism and Disposition August 2005, 33 (8) 1166-1173; DOI: https://doi.org/10.1124/dmd.105.004549
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MOLECULAR MECHANISMS REGULATING HUMAN CYP4B1 LUNG-SELECTIVE EXPRESSION
Mark T. Poch, N. Shane Cutler, Garold S. Yost and Ronald N. Hines

Drug Metabolism and Disposition August 2005, 33 (8) 1174-1184; DOI: https://doi.org/10.1124/dmd.105.004523
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IDENTIFICATION OF ESTERASES EXPRESSED IN CACO-2 CELLS AND EFFECTS OF THEIR HYDROLYZING ACTIVITY IN PREDICTING HUMAN INTESTINAL ABSORPTION
Teruko Imai, Masumi Imoto, Hisae Sakamoto and Mitsuru Hashimoto

Drug Metabolism and Disposition August 2005, 33 (8) 1185-1190; DOI: https://doi.org/10.1124/dmd.105.004226
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METABOLISM, EXCRETION, AND PHARMACOKINETICS OF (3-{[4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO]-METHYL}-PHENOXY)-ACETIC ACID, AN EP2 RECEPTOR-SELECTIVE PROSTAGLANDIN E2 AGONIST, IN MALE AND FEMALE SPRAGUE-DAWLEY RATS
Kim A. Johnson and Chandra Prakash

Drug Metabolism and Disposition August 2005, 33 (8) 1191-1201; DOI: https://doi.org/10.1124/dmd.105.004713
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CHARACTERIZATION OF NOVEL CYP2A6 POLYMORPHIC ALLELES (CYP2A6^*18 AND CYP2A6^*19) THAT AFFECT ENZYMATIC ACTIVITY
Tatsuki Fukami, Miki Nakajima, Eriko Higashi, Hiroyuki Yamanaka, Haruko Sakai, Howard L. McLeod and Tsuyoshi Yokoi

Drug Metabolism and Disposition August 2005, 33 (8) 1202-1210; DOI: https://doi.org/10.1124/dmd.105.004994
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AUTOMATED SCREENING WITH CONFIRMATION OF MECHANISM-BASED INACTIVATION OF CYP3A4, CYP2C9, CYP2C19, CYP2D6, AND CYP1A2 IN POOLED HUMAN LIVER MICROSOMES
Heng-Keang Lim, Nicholas Duczak, Linda Brougham, Michael Elliot, Krupa Patel and Kelvin Chan

Drug Metabolism and Disposition August 2005, 33 (8) 1211-1219; DOI: https://doi.org/10.1124/dmd.104.003475
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EFFECTS OF DIHYDROPYRIDINES AND PYRIDINES ON MULTIDRUG RESISTANCE MEDIATED BY BREAST CANCER RESISTANCE PROTEIN: IN VITRO AND IN VIVO STUDIES
Xiao-fei Zhou, Xinning Yang, Qi Wang, Robert A. Coburn and Marilyn E. Morris

Drug Metabolism and Disposition August 2005, 33 (8) 1220-1228; DOI: https://doi.org/10.1124/dmd.104.003558
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CHARACTERIZATION OF MICROSOMAL CYTOCHROME P450-DEPENDENT MONOOXYGENASES IN THE RAT OLFACTORY MUCOSA
Anne-Laure Minn, Hélène Pelczar, Claire Denizot, Michel Martinet, Jean-Marie Heydel, Bernard Walther, Alain Minn, Hervé Goudonnet and Yves Artur

Drug Metabolism and Disposition August 2005, 33 (8) 1229-1237; DOI: https://doi.org/10.1124/dmd.105.004085
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MODULATION OF HEPATIC CANALICULAR OR BASOLATERAL TRANSPORT PROTEINS ALTERS HEPATOBILIARY DISPOSITION OF A MODEL ORGANIC ANION IN THE ISOLATED PERFUSED RAT LIVER
Priyamvada Chandra, Brendan M. Johnson, Peijin Zhang, Gary M. Pollack and Kim L. R. Brouwer

Drug Metabolism and Disposition August 2005, 33 (8) 1238-1243; DOI: https://doi.org/10.1124/dmd.105.003665
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SP1 AND SP3 REGULATE BASAL TRANSCRIPTION OF THE HUMAN CYP2F1 GENE
Jie Wan, Brian A. Carr, N. Shane Cutler, Diane L. Lanza, Ronald N. Hines and Garold S. Yost

Drug Metabolism and Disposition August 2005, 33 (8) 1244-1253; DOI: https://doi.org/10.1124/dmd.105.004069
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FUNCTIONAL ANALYSIS OF SIX HUMAN ARYL HYDROCARBON RECEPTOR VARIANTS IN A JAPANESE POPULATION
Satoru Koyano, Yoshiro Saito, Hiromi Fukushima-Uesaka, Seiichi Ishida, Shogo Ozawa, Naoyuki Kamatani, Hironobu Minami, Atsushi Ohtsu, Tetsuya Hamaguchi, Kuniaki Shirao, Teruhiko Yoshida, Nagahiro Saijo, Hideto Jinno and Jun-Ichi Sawada

Drug Metabolism and Disposition August 2005, 33 (8) 1254-1260; DOI: https://doi.org/10.1124/dmd.105.004655

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