Table of Contents

Articles

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  ENANTIOSELECTIVE METABOLISM AND CYTOTOXICITY OF R-IFOSFAMIDE AND S-IFOSFAMIDE BY TUMOR CELL-EXPRESSED CYTOCHROMES P450

  Chong-Sheng Chen, Youssef Jounaidi and David J. Waxman

  Drug Metabolism and Disposition September 2005, 33 (9) 1261-1267; DOI: https://doi.org/10.1124/dmd.105.004788
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  POPULATION PHARMACOKINETICS OF CYCLOSPORINE IN CLINICAL RENAL TRANSPLANT PATIENTS

  Ke-Hua Wu, Yi-Min Cui, Jin-Feng Guo, Ying Zhou, Suo-Di Zhai, Fu-De Cui and Wei Lu

  Drug Metabolism and Disposition September 2005, 33 (9) 1268-1275; DOI: https://doi.org/10.1124/dmd.105.004358
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  REGULATION OF MOUSE ORGANIC ANION-TRANSPORTING POLYPEPTIDES (OATPS) IN LIVER BY PROTOTYPICAL MICROSOMAL ENZYME INDUCERS THAT ACTIVATE DISTINCT TRANSCRIPTION FACTOR PATHWAYS

  Xingguo Cheng, Jonathan Maher, Matthew Z. Dieter and Curtis D. Klaassen

  Drug Metabolism and Disposition September 2005, 33 (9) 1276-1282; DOI: https://doi.org/10.1124/dmd.105.003988
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  EFFECT OF CYP2D6*10 ALLELE ON THE PHARMACOKINETICS OF LORATADINE IN CHINESE SUBJECTS

  Ophelia Q. P. Yin, X. J. Shi, B. Tomlinson and Moses S. S. Chow

  Drug Metabolism and Disposition September 2005, 33 (9) 1283-1287; DOI: https://doi.org/10.1124/dmd.105.005025
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  ACCURACY OF ALLOMETRICALLY PREDICTED PHARMACOKINETIC PARAMETERS IN HUMANS: ROLE OF SPECIES SELECTION

  Huadong Tang and Michael Mayersohn

  Drug Metabolism and Disposition September 2005, 33 (9) 1288-1293; DOI: https://doi.org/10.1124/dmd.105.004127
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  A MATHEMATICAL DESCRIPTION OF THE FUNCTIONALITY OF CORRECTION FACTORS USED IN ALLOMETRY FOR PREDICTING HUMAN DRUG CLEARANCE

  Huadong Tang and Michael Mayersohn

  Drug Metabolism and Disposition September 2005, 33 (9) 1294-1296; DOI: https://doi.org/10.1124/dmd.105.004135
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  A NOVEL MODEL FOR PREDICTION OF HUMAN DRUG CLEARANCE BY ALLOMETRIC SCALING

  Huadong Tang and Michael Mayersohn

  Drug Metabolism and Disposition September 2005, 33 (9) 1297-1303; DOI: https://doi.org/10.1124/dmd.105.004143
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  A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

  Robert J. Riley, D. F. McGinnity and R. P. Austin

  Drug Metabolism and Disposition September 2005, 33 (9) 1304-1311; DOI: https://doi.org/10.1124/dmd.105.004259
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  INVOLVEMENT OF MOLYBDENUM HYDROXYLASES IN REDUCTIVE METABOLISM OF NITRO POLYCYCLIC AROMATIC HYDROCARBONS IN MAMMALIAN SKIN

  Osamu Ueda, Kazumi Sugihara, Shigeru Ohta and Shigeyuki Kitamura

  Drug Metabolism and Disposition September 2005, 33 (9) 1312-1318; DOI: https://doi.org/10.1124/dmd.105.005306
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  DIRECT DETERMINATION OF UNBOUND INTRINSIC DRUG CLEARANCE IN THE MICROSOMAL STABILITY ASSAY

  Claudio Giuliano, Mark Jairaj, Christian M. Zafiu and Ralph Laufer

  Drug Metabolism and Disposition September 2005, 33 (9) 1319-1324; DOI: https://doi.org/10.1124/dmd.105.005033
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  THE USE OF SANDWICH-CULTURED RAT HEPATOCYTES TO DETERMINE THE INTRINSIC CLEARANCE OF COMPOUNDS WITH DIFFERENT EXTRACTION RATIOS: 7-ETHOXYCOUMARIN AND WARFARIN

  Nicoline Treijtel, Hanneke van Helvoort, Arjan Barendregt, Bas J. Blaauboer and Jan C. H. van Eijkeren

  Drug Metabolism and Disposition September 2005, 33 (9) 1325-1332; DOI: https://doi.org/10.1124/dmd.105.004390
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  EXPRESSION OF HUMAN PHASE II ENZYMES IN CHIMERIC MICE WITH HUMANIZED LIVER

  Miki Katoh, Tomohito Matsui, Hirotoshi Okumura, Miki Nakajima, Masuhiro Nishimura, Shinsaku Naito, Chise Tateno, Katsutoshi Yoshizato and Tsuyoshi Yokoi

  Drug Metabolism and Disposition September 2005, 33 (9) 1333-1340; DOI: https://doi.org/10.1124/dmd.105.005157
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  SULFONATION OF ENVIRONMENTAL CHEMICALS AND THEIR METABOLITES IN THE POLAR BEAR (Ursus maritimus)

  James C. Sacco and Margaret O. James

  Drug Metabolism and Disposition September 2005, 33 (9) 1341-1348; DOI: https://doi.org/10.1124/dmd.105.004648
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  UDP-GLUCURONOSYLTRANSFERASE 2B7 IS THE MAJOR ENZYME RESPONSIBLE FOR GEMCABENE GLUCURONIDATION IN HUMAN LIVER MICROSOMES

  Jonathan N. Bauman, Theunis C. Goosen, Meera Tugnait, Vincent Peterkin, Susan I. Hurst, Lee C. Menning, Mark Milad, Michael H. Court and J. Andrew Williams

  Drug Metabolism and Disposition September 2005, 33 (9) 1349-1354; DOI: https://doi.org/10.1124/dmd.105.005108
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  CANALICULAR AND SINUSOIDAL DISPOSITION OF BILIRUBIN MONO- AND DIGLUCURONIDES IN SANDWICH-CULTURED HUMAN AND RAT PRIMARY HEPATOCYTES

  György Lengyel, Zsuzsa Veres, Pál Szabó, László Vereczkey and Katalin Jemnitz

  Drug Metabolism and Disposition September 2005, 33 (9) 1355-1360; DOI: https://doi.org/10.1124/dmd.105.004481
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  CYP2A6 IS A PRINCIPAL ENZYME INVOLVED IN HYDROXYLATION OF 1,7-DIMETHYLXANTHINE, A MAIN CAFFEINE METABOLITE, IN HUMANS

  Miyuki Kimura, Hiroshi Yamazaki, Masaki Fujieda, Kazuma Kiyotani, Goro Honda, Junji Saruwatari, Kazuko Nakagawa, Takashi Ishizaki and Tetsuya Kamataki

  Drug Metabolism and Disposition September 2005, 33 (9) 1361-1366; DOI: https://doi.org/10.1124/dmd.105.004796
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  METABOLISM OF THE ONE-RING OPEN METABOLITES OF THE CARDIOPROTECTIVE DRUG DEXRAZOXANE TO ITS ACTIVE METAL-CHELATING FORM IN THE RAT

  Patricia E. Schroeder and Brian B. Hasinoff

  Drug Metabolism and Disposition September 2005, 33 (9) 1367-1372; DOI: https://doi.org/10.1124/dmd.105.005546
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  METABOLISM AND DISPOSITION OF A POTENT GROUP II METABOTROPIC GLUTAMATE RECEPTOR AGONIST, IN RATS, DOGS, AND MONKEYS

  Joyce K. James, Masato Nakamura, Atsuro Nakazato, Kanyin E. Zhang, Merryl Cramer, Janice Brunner, Jacquelynn Cook and Weichao G. Chen

  Drug Metabolism and Disposition September 2005, 33 (9) 1373-1381; DOI: https://doi.org/10.1124/dmd.105.004978
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  BIMOLECULAR FLUORESCENCE COMPLEMENTATION ANALYSIS OF CYTOCHROME P450 2C2, 2E1, AND NADPH-CYTOCHROME P450 REDUCTASE MOLECULAR INTERACTIONS IN LIVING CELLS

  Cengiz Ozalp, Elzbieta Szczesna-Skorupa and Byron Kemper

  Drug Metabolism and Disposition September 2005, 33 (9) 1382-1390; DOI: https://doi.org/10.1124/dmd.105.005538
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  ISOFORM-SPECIFIC EXPRESSION AND INDUCTION OF UDP-GLUCURONOSYLTRANSFERASE IN IMMUNOACTIVATED PERITONEAL MACROPHAGES OF THE RAT

  Yuki Tochigi, Naoko Yamashiki, Satoru Ohgiya, Sawako Ganaha and Hiroshi Yokota

  Drug Metabolism and Disposition September 2005, 33 (9) 1391-1398; DOI: https://doi.org/10.1124/dmd.105.004879