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Research ArticleArticle

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

Robert J. Riley, D. F. McGinnity and R. P. Austin
Drug Metabolism and Disposition September 2005, 33 (9) 1304-1311; DOI: https://doi.org/10.1124/dmd.105.004259
Robert J. Riley
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D. F. McGinnity
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R. P. Austin
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Article Information

vol. 33 no. 9 1304-1311
DOI 
https://doi.org/10.1124/dmd.105.004259
PubMed 
15932954

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 14, 2005
  • Accepted May 26, 2005
  • Published online August 19, 2005.

Article Versions

  • Earlier version (June 2, 2005 - 08:15).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Robert J. Riley,
  2. D. F. McGinnity and
  3. R. P. Austin
  1. Department of Physical and Metabolic Science, AstraZeneca R&D Charnwood, Loughborough, Leicestershire, United Kingdom
  1. Address correspondence to:
    Robert J. Riley, Department of Physical and Metabolic Science, AstraZeneca R&D Charnwood, Loughborough, Leicestershire, LE11 5RH, U.K. E-mail: rob.riley{at}astrazeneca.com
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Drug Metabolism and Disposition: 33 (9)
Drug Metabolism and Disposition
Vol. 33, Issue 9
1 Sep 2005
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Research ArticleArticle

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

Robert J. Riley, D. F. McGinnity and R. P. Austin
Drug Metabolism and Disposition September 1, 2005, 33 (9) 1304-1311; DOI: https://doi.org/10.1124/dmd.105.004259

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Research ArticleArticle

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

Robert J. Riley, D. F. McGinnity and R. P. Austin
Drug Metabolism and Disposition September 1, 2005, 33 (9) 1304-1311; DOI: https://doi.org/10.1124/dmd.105.004259
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