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Research ArticleArticle

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

Robert J. Riley, D. F. McGinnity and R. P. Austin
Drug Metabolism and Disposition September 2005, 33 (9) 1304-1311; DOI: https://doi.org/10.1124/dmd.105.004259

Article Information

vol. 33 no. 9 1304-1311
DOI 
https://doi.org/10.1124/dmd.105.004259
PubMed 
15932954
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 14, 2005
  • Accepted May 26, 2005
  • Published online August 19, 2005.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Robert J. Riley,
  2. D. F. McGinnity and
  3. R. P. Austin
  1. Department of Physical and Metabolic Science, AstraZeneca R&D Charnwood, Loughborough, Leicestershire, United Kingdom
  1. Address correspondence to:
    Robert J. Riley, Department of Physical and Metabolic Science, AstraZeneca R&D Charnwood, Loughborough, Leicestershire, LE11 5RH, U.K. E-mail: rob.riley{at}astrazeneca.com
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Research ArticleArticle

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

Robert J. Riley, D. F. McGinnity and R. P. Austin
Drug Metabolism and Disposition September 1, 2005, 33 (9) 1304-1311; DOI: https://doi.org/10.1124/dmd.105.004259
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