Drug Metabolism and Disposition: 34 (1)

January 01, 2006; Volume 34,Issue 1

MINIREVIEWS

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MECHANISM-BASED INACTIVATION AND REVERSIBILITY: IS THERE A NEW TREND IN THE INACTIVATION OF CYTOCHROME P450 ENZYMES?
Anna L. Blobaum

Drug Metabolism and Disposition January 2006, 34 (1) 1-7; DOI: https://doi.org/10.1124/dmd.105.004747

Short Communications

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DOSE-DEPENDENT LEVELS OF EPIGALLOCATECHIN-3-GALLATE IN HUMAN COLON CANCER CELLS AND MOUSE PLASMA AND TISSUES
Joshua D. Lambert, Mao-Jung Lee, Lauren Diamond, Jihyeung Ju, Jungil Hong, Mousumi Bose, Harold L. Newmark and Chung S. Yang

Drug Metabolism and Disposition January 2006, 34 (1) 8-11; DOI: https://doi.org/10.1124/dmd.104.003434
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FUNCTIONAL CHARACTERIZATION AND HAPLOTYPE ANALYSIS OF POLYMORPHISMS IN THE HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER, ENT2
Ryan P. Owen, Leah L. Lagpacan, Travis R. Taylor, Melanie De La Cruz, Conrad C. Huang, Michiko Kawamoto, Susan J. Johns, Doug Stryke, Thomas E. Ferrin and Kathleen M. Giacomini

Drug Metabolism and Disposition January 2006, 34 (1) 12-15; DOI: https://doi.org/10.1124/dmd.105.006270
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ROLE OF HUMAN CYCLOOXYGENASE-2 IN THE BIOACTIVATION OF DAPSONE AND SULFAMETHOXAZOLE
Piyush M. Vyas, Sanjoy Roychowdhury and Craig K. Svensson

Drug Metabolism and Disposition January 2006, 34 (1) 16-18; DOI: https://doi.org/10.1124/dmd.105.006890

Articles

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QUANTITATIVE ANALYSIS OF FMO GENE mRNA LEVELS IN HUMAN TISSUES
Jun Zhang and John R. Cashman

Drug Metabolism and Disposition January 2006, 34 (1) 19-26; DOI: https://doi.org/10.1124/dmd.105.006171
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MODULATION OF CYP1A2 AND CYP3A6 CATALYTIC ACTIVITIES BY SERUM FROM RABBITS WITH A TURPENTINE-INDUCED INFLAMMATORY REACTION AND INTERLEUKIN 6
Oksana Kourylko, Caroline Fradette, Mathieu Arcand and Patrick du Souich

Drug Metabolism and Disposition January 2006, 34 (1) 27-35; DOI: https://doi.org/10.1124/dmd.105.006528
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INHIBITION AND RECOVERY OF RAT HEPATIC GLUTATHIONE S-TRANSFERASE ZETA AND ALTERATION OF TYROSINE METABOLISM FOLLOWING DICHLOROACETATE EXPOSURE AND WITHDRAWAL
Xu Guo, Vaishali Dixit, Huiping Liu, Albert L. Shroads, George N. Henderson, Margaret O. James and Peter W. Stacpoole

Drug Metabolism and Disposition January 2006, 34 (1) 36-42; DOI: https://doi.org/10.1124/dmd.105.003996
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DETERMINATION OF THE ENZYME(S) INVOLVED IN THE METABOLISM OF AMIODARONE IN LIVER AND INTESTINE OF RAT: THE CONTRIBUTION OF CYTOCHROME P450 3A ISOFORMS
Anooshirvan Shayeganpour, Ayman O. S. El-Kadi and Dion R. Brocks

Drug Metabolism and Disposition January 2006, 34 (1) 43-50; DOI: https://doi.org/10.1124/dmd.105.006742
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STRUCTURAL ELUCIDATION OF HYDROXYLATED METABOLITES OF THE ISOFLAVAN EQUOL BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY
Corinna E. Rüfer, Hansruedi Glatt and Sabine E. Kulling

Drug Metabolism and Disposition January 2006, 34 (1) 51-60; DOI: https://doi.org/10.1124/dmd.105.004929
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CYP2A5-MEDIATED ACTIVATION AND EARLY ULTRASTRUCTURAL CHANGES IN THE OLFACTORY MUCOSA: STUDIES ON 2,6-DICHLOROPHENYL METHYLSULFONE
Anna Franzén, Carina Carlsson, Veronica Hermansson, Matti Lang and Eva B. Brittebo

Drug Metabolism and Disposition January 2006, 34 (1) 61-68; DOI: https://doi.org/10.1124/dmd.105.006221
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EFFECT OF MILK THISTLE (SILYBUM MARIANUM) AND BLACK COHOSH (CIMICIFUGA RACEMOSA) SUPPLEMENTATION ON DIGOXIN PHARMACOKINETICS IN HUMANS
Bill J. Gurley, Gary W. Barone, D. Keith Williams, Julie Carrier, Philip Breen, C. Ryan Yates, Peng-fei Song, Martha A. Hubbard, Yudong Tong and Sreekhar Cheboyina

Drug Metabolism and Disposition January 2006, 34 (1) 69-74; DOI: https://doi.org/10.1124/dmd.105.006312
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EXPRESSION OF CYTOCHROMES P450, CONJUGATING ENZYMES AND NUCLEAR RECEPTORS IN HUMAN HEPATOMA HepaRG CELLS
Caroline Aninat, Amélie Piton, Denise Glaise, Typhen Le Charpentier, Sophie Langouët, Fabrice Morel, Christiane Guguen-Guillouzo and André Guillouzo

Drug Metabolism and Disposition January 2006, 34 (1) 75-83; DOI: https://doi.org/10.1124/dmd.105.006759
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APPLICATION OF A GENERIC PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL TO THE ESTIMATION OF XENOBIOTIC LEVELS IN RAT PLASMA
F. A. Brightman, D. E. Leahy, G. E. Searle and S. Thomas

Drug Metabolism and Disposition January 2006, 34 (1) 84-93; DOI: https://doi.org/10.1124/dmd.105.004804
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APPLICATION OF A GENERIC PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL TO THE ESTIMATION OF XENOBIOTIC LEVELS IN HUMAN PLASMA
F. A. Brightman, D. E. Leahy, G. E. Searle and S. Thomas

Drug Metabolism and Disposition January 2006, 34 (1) 94-101; DOI: https://doi.org/10.1124/dmd.105.004838
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ACYL-COENZYME A FORMATION OF SIMVASTATIN IN MOUSE LIVER PREPARATIONS
Chunze Li, Raju Subramanian, Sean Yu and Thomayant Prueksaritanont

Drug Metabolism and Disposition January 2006, 34 (1) 102-110; DOI: https://doi.org/10.1124/dmd.105.006650
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NC100668, A NEW TRACER FOR IMAGING OF VENOUS THROMBOEMBOLISM: DISPOSITION AND METABOLISM IN RATS
Tore Skotland, Svein Olaf Hustvedt, Inger Oulie, Petter Balke Jacobsen, Grete Arneberg Friisk, Ann Svendsen Langøy, Steinar Uran, Jessie Sandosham, Alan Cuthbertson and Kim Gunnar Toft

Drug Metabolism and Disposition January 2006, 34 (1) 111-120; DOI: https://doi.org/10.1124/dmd.105.006239
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METABOLISM AND DISPOSITION OF VARENICLINE, A SELECTIVE α4β2 ACETYLCHOLINE RECEPTOR PARTIAL AGONIST, IN VIVO AND IN VITRO
R. Scott Obach, Anne E. Reed-Hagen, Suzanne S. Krueger, Beth J. Obach, Thomas N. O'Connell, Kathleen S. Zandi, Sandra Miller and Jotham W. Coe

Drug Metabolism and Disposition January 2006, 34 (1) 121-130; DOI: https://doi.org/10.1124/dmd.105.006767
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NUCLEAR RECEPTOR EXPRESSION IN FETAL AND PEDIATRIC LIVER: CORRELATION WITH CYP3A EXPRESSION
Carrie A. Vyhlidal, Roger Gaedigk and J. Steven Leeder

Drug Metabolism and Disposition January 2006, 34 (1) 131-137; DOI: https://doi.org/10.1124/dmd.105.005967
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TRANSCRIPTIONAL REGULATION OF THE PXR GENE: IDENTIFICATION AND CHARACTERIZATION OF A FUNCTIONAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α BINDING SITE WITHIN THE PROXIMAL PROMOTER OF PXR
Sihem Aouabdi, Gordon Gibson and Nick Plant

Drug Metabolism and Disposition January 2006, 34 (1) 138-144; DOI: https://doi.org/10.1124/dmd.105.006064
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EVIDENCE FOR THE BIOACTIVATION OF ZOMEPIRAC AND TOLMETIN BY AN OXIDATIVE PATHWAY: IDENTIFICATION OF GLUTATHIONE ADDUCTS IN VITRO IN HUMAN LIVER MICROSOMES AND IN VIVO IN RATS
Qing Chen, George A. Doss, Elaine C. Tung, Wensheng Liu, Yui S. Tang, Matthew P. Braun, Varsha Didolkar, John R. Strauss, Regina W. Wang, Ralph A. Stearns, David C. Evans, Thomas A. Baillie and Wei Tang

Drug Metabolism and Disposition January 2006, 34 (1) 145-151; DOI: https://doi.org/10.1124/dmd.105.004341
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TRANSCRIPTIONAL REGULATION OF THE NAD(P)H:QUINONE OXIDOREDUCTASE 1 AND GLUTATHIONE S-TRANSFERASE YA GENES BY MERCURY, LEAD, AND COPPER
Hesham M. Korashy and Ayman O. S. El-Kadi

Drug Metabolism and Disposition January 2006, 34 (1) 152-165; DOI: https://doi.org/10.1124/dmd.105.005397
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PREDICTION OF TIME-DEPENDENT CYP3A4 DRUG-DRUG INTERACTIONS: IMPACT OF ENZYME DEGRADATION, PARALLEL ELIMINATION PATHWAYS, AND INTESTINAL INHIBITION
Aleksandra Galetin, Howard Burt, Laura Gibbons and J. Brian Houston

Drug Metabolism and Disposition January 2006, 34 (1) 166-175; DOI: https://doi.org/10.1124/dmd.105.006874
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IN VITRO METABOLISM OF NAPHTHALENE BY HUMAN LIVER MICROSOMAL CYTOCHROME P450 ENZYMES
Taehyeon M. Cho, Randy L. Rose and Ernest Hodgson

Drug Metabolism and Disposition January 2006, 34 (1) 176-183; DOI: https://doi.org/10.1124/dmd.105.005785
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SLOW ELIMINATION OF NONYLPHENOL FROM RAT INTESTINE
Tomo Daidoji, Mihoko Ozawa, Hirokazu Sakamoto, Toshiro Sako, Hiroki Inoue, Ryo Kurihara, Shinya Hashimoto and Hiroshi Yokota

Drug Metabolism and Disposition January 2006, 34 (1) 184-190; DOI: https://doi.org/10.1124/dmd.105.007229

Accelerated Communication

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GLUCURONIDATION CONVERTS GEMFIBROZIL TO A POTENT, METABOLISM-DEPENDENT INHIBITOR OF CYP2C8: IMPLICATIONS FOR DRUG-DRUG INTERACTIONS
Brian W. Ogilvie, Donglu Zhang, Wenying Li, A. David Rodrigues, Amy E. Gipson, Jeff Holsapple, Paul Toren and Andrew Parkinson

Drug Metabolism and Disposition January 2006, 34 (1) 191-197; DOI: https://doi.org/10.1124/dmd.105.007633

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