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MECHANISM-BASED INACTIVATION AND REVERSIBILITY: IS THERE A NEW TREND IN THE INACTIVATION OF CYTOCHROME P450 ENZYMES?

Anna L. Blobaum
Drug Metabolism and Disposition January 2006, 34 (1) 1-7; DOI: https://doi.org/10.1124/dmd.105.004747
Anna L. Blobaum
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Article Information

vol. 34 no. 1 1-7
DOI 
https://doi.org/10.1124/dmd.105.004747
PubMed 
16369051

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 14, 2005
  • Accepted October 25, 2005
  • Published online December 20, 2005.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Anna L. Blobaum
  1. Department of Biochemistry, Vanderbilt University, Nashville, Tennessee
  1. Address correspondence to:
    Dr. Anna L. Blobaum, Department of Biochemistry, Vanderbilt University, 854 Robinson Research Building, 23rd Avenue South at Pierce, Nashville, TN 37232. E-mail: anna.l.blobaum{at}vanderbilt.edu
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Drug Metabolism and Disposition: 34 (1)
Drug Metabolism and Disposition
Vol. 34, Issue 1
1 Jan 2006
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MECHANISM-BASED INACTIVATION AND REVERSIBILITY: IS THERE A NEW TREND IN THE INACTIVATION OF CYTOCHROME P450 ENZYMES?

Anna L. Blobaum
Drug Metabolism and Disposition January 1, 2006, 34 (1) 1-7; DOI: https://doi.org/10.1124/dmd.105.004747

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MECHANISM-BASED INACTIVATION AND REVERSIBILITY: IS THERE A NEW TREND IN THE INACTIVATION OF CYTOCHROME P450 ENZYMES?

Anna L. Blobaum
Drug Metabolism and Disposition January 1, 2006, 34 (1) 1-7; DOI: https://doi.org/10.1124/dmd.105.004747
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  • Article
    • Abstract
    • Mechanism-Based Inactivation and Reversibility (Overview)
    • Acetylenic Mechanism-Based Inactivators
    • Unique Spectral Intermediates Formed during Reversible Inactivation
    • The Role of P450 Active Site Architecture in Reversibility
    • Chemical Determinants of Reversibility
    • Conclusions and Future Directions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
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