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Drug Metabolism & Disposition

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Table of Contents

October 01, 2006; Volume 34,Issue 10

Short Communication

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    Cytochrome P450 Expression of Cultured Rat Small Hepatocytes after Long-Term Cryopreservation
    Hidekazu Ooe, Junko Kon, Shigeki Miyamoto, Yoshiyasu Ozone, Shin-ichi Ninomiya and Toshihiro Mitaka
    Drug Metabolism and Disposition October 2006, 34 (10) 1667-1671; DOI: https://doi.org/10.1124/dmd.105.008342

Articles

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    CYP2A13 in Human Respiratory Tissues and Lung Cancers: An Immunohistochemical Study with A New Peptide-Specific Antibody
    Liang-Ru Zhu, Paul E. Thomas, Gang Lu, Kenneth R. Reuhl, Guang-Yu Yang, Li-Dong Wang, Shou-Lin Wang, Chung S. Yang, Xiao-Yang He and Jun-Yan Hong
    Drug Metabolism and Disposition October 2006, 34 (10) 1672-1676; DOI: https://doi.org/10.1124/dmd.106.011049
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    Dietary Inulin Alleviates Hepatic Steatosis and Xenobiotics-Induced Liver Injury in Rats Fed a High-Fat and High-Sucrose Diet: Association with the Suppression of Hepatic Cytochrome P450 and Hepatocyte Nuclear Factor 4α Expression
    Junko Sugatani, Tadashi Wada, Makoto Osabe, Kasumi Yamakawa, Kouichi Yoshinari and Masao Miwa
    Drug Metabolism and Disposition October 2006, 34 (10) 1677-1687; DOI: https://doi.org/10.1124/dmd.106.010645
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    Amiodarone Analog-Dependent Effects on CYP2C9-Mediated Metabolism and Kinetic Profiles
    Vikas Kumar, Chuck W. Locuson, Yuk Y. Sham and Timothy S. Tracy
    Drug Metabolism and Disposition October 2006, 34 (10) 1688-1696; DOI: https://doi.org/10.1124/dmd.106.010678
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    In Vivo and in Vitro Metabolism of Arylamine Procarcinogens in Acetyltransferase-Deficient Mice
    K. S. Sugamori, D. Brenneman and D. M. Grant
    Drug Metabolism and Disposition October 2006, 34 (10) 1697-1702; DOI: https://doi.org/10.1124/dmd.106.010819
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    Characterization of the Rhesus Monkey CYP3A64 Enzyme: Species Comparisons of CYP3A Substrate Specificity and Kinetics Using Baculovirus-Expressed Recombinant Enzymes
    Brian Carr, Ryan Norcross, Yulin Fang, Ping Lu, A. David Rodrigues, Magang Shou, Tom Rushmore and Catherine Booth-Genthe
    Drug Metabolism and Disposition October 2006, 34 (10) 1703-1712; DOI: https://doi.org/10.1124/dmd.106.009977
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    In Vivo Metabolism and Final Disposition of a Novel Nonsteroidal Androgen in Rats and Dogs
    Minoli A. Perera, Donghua Yin, Di Wu, Kenneth K. Chan, Duane D. Miller and James Dalton
    Drug Metabolism and Disposition October 2006, 34 (10) 1713-1721; DOI: https://doi.org/10.1124/dmd.106.009985
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    Detection and Characterization of Metabolites in Biological Matrices Using Mass Defect Filtering of Liquid Chromatography/High Resolution Mass Spectrometry Data
    Mingshe Zhu, Li Ma, Donglu Zhang, Kenneth Ray, Weiping Zhao, W. Griffith Humphreys, Gary Skiles, Mark Sanders and Haiying Zhang
    Drug Metabolism and Disposition October 2006, 34 (10) 1722-1733; DOI: https://doi.org/10.1124/dmd.106.009241
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    Substrate Specificity of Carboxylesterase Isozymes and Their Contribution to Hydrolase Activity in Human Liver and Small Intestine
    Teruko Imai, Megumi Taketani, Mayumi Shii, Masakiyo Hosokawa and Kan Chiba
    Drug Metabolism and Disposition October 2006, 34 (10) 1734-1741; DOI: https://doi.org/10.1124/dmd.106.009381
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    Use of Immortalized Human Hepatocytes to Predict the Magnitude of Clinical Drug-Drug Interactions Caused by CYP3A4 Induction
    Sharon L. Ripp, Jessica B. Mills, Odette A. Fahmi, Kristen A. Trevena, Jennifer L. Liras, Tristan S. Maurer and Sonia M. de Morais
    Drug Metabolism and Disposition October 2006, 34 (10) 1742-1748; DOI: https://doi.org/10.1124/dmd.106.010132
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    Characterization of Proline-Serine-Rich Carboxyl Terminus in Human Sulfotransferase 2B1b: Immunogenicity, Subcellular Localization, Kinetic Properties, and Phosphorylation
    Dongning He and Charles N. Falany
    Drug Metabolism and Disposition October 2006, 34 (10) 1749-1755; DOI: https://doi.org/10.1124/dmd.106.011114
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    Differential Regulation of Sinusoidal and Canalicular Hepatic Drug Transporter Expression by Xenobiotics Activating Drug-Sensing Receptors in Primary Human Hepatocytes
    Emilie Jigorel, Marc Le Vee, Claire Boursier-Neyret, Yannick Parmentier and Olivier Fardel
    Drug Metabolism and Disposition October 2006, 34 (10) 1756-1763; DOI: https://doi.org/10.1124/dmd.106.010033
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    Species Differences in the in Vitro Metabolism of Deltamethrin and Esfenvalerate: Differential Oxidative and Hydrolytic Metabolism by Humans and Rats
    Stephen J. Godin, Edward J. Scollon, Michael F. Hughes, Philip M. Potter, Michael J. DeVito and Matthew K. Ross
    Drug Metabolism and Disposition October 2006, 34 (10) 1764-1771; DOI: https://doi.org/10.1124/dmd.106.010058
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    Induction of Rat UDP-Glucuronosyltransferases in Liver and Duodenum by Microsomal Enzyme Inducers That Activate Various Transcriptional Pathways
    M. K. Shelby and C. D. Klaassen
    Drug Metabolism and Disposition October 2006, 34 (10) 1772-1778; DOI: https://doi.org/10.1124/dmd.106.010397
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    Metabolism of Endosulfan-α by Human Liver Microsomes and Its Utility as a Simultaneous in Vitro Probe for CYP2B6 and CYP3A4
    Richard C. T. Casabar, Andrew D. Wallace, Ernest Hodgson and Randy L. Rose
    Drug Metabolism and Disposition October 2006, 34 (10) 1779-1785; DOI: https://doi.org/10.1124/dmd.106.010199
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    Methylated Flavonoids Have Greatly Improved Intestinal Absorption and Metabolic Stability
    Xia Wen and Thomas Walle
    Drug Metabolism and Disposition October 2006, 34 (10) 1786-1792; DOI: https://doi.org/10.1124/dmd.106.011122
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In this issue

Drug Metabolism and Disposition: 34 (10)
Drug Metabolism and Disposition
Vol. 34, Issue 10
1 Oct 2006
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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