Use of Immortalized Human Hepatocytes to Predict the Magnitude of Clinical Drug-Drug Interactions Caused by CYP3A4 Induction

Department of Pharmacokinetics, Dynamics and Metabolism (S.L.R., O.A.F., K.A.T., J.L.L., T.S.M., S.M.D.) and Department of Scientific Development (J.B.M.), Pfizer Global Research and Development, Groton Laboratories, Groton, Connecticut

Address correspondence to:
Dr. Sonia M. de Morais, Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Groton, CT 06340. E-mail: sonia.m.demorais{at}pfizer.com

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