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Drug Metabolism & Disposition

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Table of Contents

November 01, 2006; Volume 34,Issue 11

Short Communications

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    Characterization of Ebastine, Hydroxyebastine, and Carebastine Metabolism by Human Liver Microsomes and Expressed Cytochrome P450 Enzymes: Major Roles for CYP2J2 and CYP3A
    Kwang-Hyeon Liu, Mi-Gyung Kim, Dong-Jun Lee, Yune-Jung Yoon, Min-Jung Kim, Ji-Hong Shon, Chang Soo Choi, Young Kil Choi, Zeuresenay Desta and Jae-Gook Shin
    Drug Metabolism and Disposition November 2006, 34 (11) 1793-1797; DOI: https://doi.org/10.1124/dmd.106.010488
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    Identification of Enzymes Responsible for Primary and Sequential Oxygenation Reactions of Capravirine in Human Liver Microsomes
    Hai-Zhi Bu, Ping Zhao, Ping Kang, William F. Pool and Ellen Y. Wu
    Drug Metabolism and Disposition November 2006, 34 (11) 1798-1802; DOI: https://doi.org/10.1124/dmd.106.011189
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    Rat Cytochrome P450 2C11 in Liver Microsomes Involved in Oxidation of Anesthetic Agent Propofol and Deactivated by Prior Treatment with Propofol
    Hiroshi Yamazaki, Makiko Shimizu, Takashi Nagashima, Masaki Minoshima and Norie Murayama
    Drug Metabolism and Disposition November 2006, 34 (11) 1803-1805; DOI: https://doi.org/10.1124/dmd.106.011627
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    Rifampin Induces the in Vitro Oxidative Metabolism, but Not the in Vivo Clearance of Diclofenac in Rhesus Monkeys
    Thomayant Prueksaritanont, Chunze Li, Cuyue Tang, Yuhsin Kuo, Kristie Strong-Basalyga and Brian Carr
    Drug Metabolism and Disposition November 2006, 34 (11) 1806-1810; DOI: https://doi.org/10.1124/dmd.106.011643

Articles

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    Elucidation of the Effects of the CYP1A2 Deficiency Polymorphism in the Metabolism of 4-Cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]pyrimidine-2-(1H)-one (YM-64227), a Phosphodiesterase Type 4 Inhibitor, and Its Metabolites in Dogs
    Daisuke Tenmizu, Kiyoshi Noguchi and Hidetaka Kamimura
    Drug Metabolism and Disposition November 2006, 34 (11) 1811-1816; DOI: https://doi.org/10.1124/dmd.106.011213
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    Metabolism and Disposition of Vatalanib (PTK787/ZK-222584) in Cancer Patients
    Lorenz M. Jost, Hans-Peter Gschwind, Tarja Jalava, Yongyu Wang, Clemens Guenther, Claire Souppart, Antje Rottmann, Karsten Denner, Felix Waldmeier, Gerhard Gross, Eric Masson and Dirk Laurent
    Drug Metabolism and Disposition November 2006, 34 (11) 1817-1828; DOI: https://doi.org/10.1124/dmd.106.009944
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    Uptake and Intracellular Binding of Lipophilic Amine Drugs by Isolated Rat Hepatocytes and Implications for Prediction of in Vivo Metabolic Clearance
    David Hallifax and J. Brian Houston
    Drug Metabolism and Disposition November 2006, 34 (11) 1829-1836; DOI: https://doi.org/10.1124/dmd.106.010413
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    Disposition of Flavonoids via Enteric Recycling: Structural Effects and Lack of Correlations between in Vitro and in Situ Metabolic Properties
    Stephen W. J. Wang, Jun Chen, Xiaobin Jia, Vincent H. Tam and Ming Hu
    Drug Metabolism and Disposition November 2006, 34 (11) 1837-1848; DOI: https://doi.org/10.1124/dmd.106.009910
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    Synthesis of Substituted Phenyl Diaziridines and Characterization as Mechanism-Based Inactivators of Human Cytochrome P450 2B6
    Chitra Sridar, Yoshimasa Kobayashi, Holly Brevig, Ute M. Kent, Satish G. Puppali, John M. Rimoldi and Paul F. Hollenberg
    Drug Metabolism and Disposition November 2006, 34 (11) 1849-1855; DOI: https://doi.org/10.1124/dmd.106.010082
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    Human Metabolism of Nebicapone (BIA 3-202), a Novel Catechol-O-Methyltransferase Inhibitor: Characterization of in Vitro Glucuronidation
    A. I. Loureiro, M. J. Bonifácio, C. Fernandes-Lopes, L. Almeida, L. C. Wright and P. Soares-Da-Silva
    Drug Metabolism and Disposition November 2006, 34 (11) 1856-1862; DOI: https://doi.org/10.1124/dmd.106.010447
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    Regulation of mRNA Expression of Xenobiotic Transporters by the Pregnane X Receptor in Mouse Liver, Kidney, and Intestine
    Xingguo Cheng and Curtis D. Klaassen
    Drug Metabolism and Disposition November 2006, 34 (11) 1863-1867; DOI: https://doi.org/10.1124/dmd.106.010520
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    Molecular Identification and Functional Characterization of Rat Multidrug and Toxin Extrusion Type Transporter 1 as an Organic Cation/H+ Antiporter in the Kidney
    Kin-ya Ohta, Katsuhisa Inoue, Yayoi Hayashi and Hiroaki Yuasa
    Drug Metabolism and Disposition November 2006, 34 (11) 1868-1874; DOI: https://doi.org/10.1124/dmd.106.010876
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    Lack of Dose-Dependent Effects of Itraconazole on the Pharmacokinetic Interaction with Fexofenadine
    Tsukasa Uno, Mikiko Shimizu, Kazunobu Sugawara and Tomonori Tateishi
    Drug Metabolism and Disposition November 2006, 34 (11) 1875-1879; DOI: https://doi.org/10.1124/dmd.106.011023
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    Metabolic Profile of FYX-051 (4-(5-Pyridin-4-yl-1H-[1,2,4]triazol-3-yl)pyridine-2-carbonitrile) in the Rat, Dog, Monkey, and Human: Identification of N-Glucuronides and N-Glucosides
    Takashi Nakazawa, Kengo Miyata, Koichi Omura, Takashi Iwanaga and Osamu Nagata
    Drug Metabolism and Disposition November 2006, 34 (11) 1880-1886; DOI: https://doi.org/10.1124/dmd.106.011692
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    Clofibrate Increases Hepatic Triiodothyronine (T3)- and Thyroxine (T4)-Glucuronosyltransferase Activities and Lowers Plasma T3 and T4 Concentrations in Pigs
    Sebastian Luci, Holger Kluge, Frank Hirche and Klaus Eder
    Drug Metabolism and Disposition November 2006, 34 (11) 1887-1892; DOI: https://doi.org/10.1124/dmd.106.011379
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    Innovative Methods to Study Human Intestinal Drug Metabolism in Vitro: Precision-Cut Slices Compared with Ussing Chamber Preparations
    Esther G. van de Kerkhof, Anna-Lena B. Ungell, Åsa K. Sjöberg, Marina H. de Jager, Constanze Hilgendorf, Inge A. M. de Graaf and Geny M. M. Groothuis
    Drug Metabolism and Disposition November 2006, 34 (11) 1893-1902; DOI: https://doi.org/10.1124/dmd.106.011148
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    Enzyme Source Effects on CYP2C9 Kinetics and Inhibition
    Vikas Kumar, Dan A. Rock, Chad J. Warren, Timothy S. Tracy and Jan L. Wahlstrom
    Drug Metabolism and Disposition November 2006, 34 (11) 1903-1908; DOI: https://doi.org/10.1124/dmd.106.010249
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    Disposition of [14C]Ruboxistaurin in Humans
    Jennifer L. Burkey, Kristina M. Campanale, Robert Barbuch, Douglas O'Bannon, James Rash, Charles Benson and David Small
    Drug Metabolism and Disposition November 2006, 34 (11) 1909-1917; DOI: https://doi.org/10.1124/dmd.106.009894
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    Pharmacokinetics, Metabolism, and Routes of Excretion of Intravenous Irofulven in Patients with Advanced Solid Tumors
    Angelo Paci, Keyvan Rezai, Alain Deroussent, Dominique De Valeriola, Micheline Re, Sophie Weill, Esteban Cvitkovic, Carmen Kahatt, Ajit Shah, Stephen Waters, Gary Weems, Gilles Vassal and François Lokiec
    Drug Metabolism and Disposition November 2006, 34 (11) 1918-1926; DOI: https://doi.org/10.1124/dmd.106.010512
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    PDZ Adaptor Protein PDZK2 Stimulates Transport Activity of Organic Cation/Carnitine Transporter OCTN2 by Modulating Cell Surface Expression
    Chizuru Watanabe, Yukio Kato, Tomoko Sugiura, Yoshiyuki Kubo, Tomohiko Wakayama, Shoichi Iseki and Akira Tsuji
    Drug Metabolism and Disposition November 2006, 34 (11) 1927-1934; DOI: https://doi.org/10.1124/dmd.106.010207
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    Porcine Brain Microvessel Endothelial Cells as an in Vitro Model to Predict in Vivo Blood-Brain Barrier Permeability
    Yan Zhang, Cheryl S. W. Li, Yuyang Ye, Kjell Johnson, Julie Poe, Shannon Johnson, Walter Bobrowski, Rosario Garrido and Cherukury Madhu
    Drug Metabolism and Disposition November 2006, 34 (11) 1935-1943; DOI: https://doi.org/10.1124/dmd.105.006437
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Drug Metabolism and Disposition: 34 (11)
Drug Metabolism and Disposition
Vol. 34, Issue 11
1 Nov 2006
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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