Table of Contents

Articles

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  Elucidation of the Effects of the CYP1A2 Deficiency Polymorphism in the Metabolism of 4-Cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]pyrimidine-2-(1H)-one (YM-64227), a Phosphodiesterase Type 4 Inhibitor, and Its Metabolites in Dogs

  Daisuke Tenmizu, Kiyoshi Noguchi and Hidetaka Kamimura

  Drug Metabolism and Disposition November 2006, 34 (11) 1811-1816; DOI: https://doi.org/10.1124/dmd.106.011213
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  Metabolism and Disposition of Vatalanib (PTK787/ZK-222584) in Cancer Patients

  Lorenz M. Jost, Hans-Peter Gschwind, Tarja Jalava, Yongyu Wang, Clemens Guenther, Claire Souppart, Antje Rottmann, Karsten Denner, Felix Waldmeier, Gerhard Gross, Eric Masson and Dirk Laurent

  Drug Metabolism and Disposition November 2006, 34 (11) 1817-1828; DOI: https://doi.org/10.1124/dmd.106.009944
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  Uptake and Intracellular Binding of Lipophilic Amine Drugs by Isolated Rat Hepatocytes and Implications for Prediction of in Vivo Metabolic Clearance

  David Hallifax and J. Brian Houston

  Drug Metabolism and Disposition November 2006, 34 (11) 1829-1836; DOI: https://doi.org/10.1124/dmd.106.010413
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  Disposition of Flavonoids via Enteric Recycling: Structural Effects and Lack of Correlations between in Vitro and in Situ Metabolic Properties

  Stephen W. J. Wang, Jun Chen, Xiaobin Jia, Vincent H. Tam and Ming Hu

  Drug Metabolism and Disposition November 2006, 34 (11) 1837-1848; DOI: https://doi.org/10.1124/dmd.106.009910
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  Synthesis of Substituted Phenyl Diaziridines and Characterization as Mechanism-Based Inactivators of Human Cytochrome P450 2B6

  Chitra Sridar, Yoshimasa Kobayashi, Holly Brevig, Ute M. Kent, Satish G. Puppali, John M. Rimoldi and Paul F. Hollenberg

  Drug Metabolism and Disposition November 2006, 34 (11) 1849-1855; DOI: https://doi.org/10.1124/dmd.106.010082
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  Human Metabolism of Nebicapone (BIA 3-202), a Novel Catechol-O-Methyltransferase Inhibitor: Characterization of in Vitro Glucuronidation

  A. I. Loureiro, M. J. Bonifácio, C. Fernandes-Lopes, L. Almeida, L. C. Wright and P. Soares-Da-Silva

  Drug Metabolism and Disposition November 2006, 34 (11) 1856-1862; DOI: https://doi.org/10.1124/dmd.106.010447
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  Regulation of mRNA Expression of Xenobiotic Transporters by the Pregnane X Receptor in Mouse Liver, Kidney, and Intestine

  Xingguo Cheng and Curtis D. Klaassen

  Drug Metabolism and Disposition November 2006, 34 (11) 1863-1867; DOI: https://doi.org/10.1124/dmd.106.010520
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  Molecular Identification and Functional Characterization of Rat Multidrug and Toxin Extrusion Type Transporter 1 as an Organic Cation/H⁺ Antiporter in the Kidney

  Kin-ya Ohta, Katsuhisa Inoue, Yayoi Hayashi and Hiroaki Yuasa

  Drug Metabolism and Disposition November 2006, 34 (11) 1868-1874; DOI: https://doi.org/10.1124/dmd.106.010876
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  Lack of Dose-Dependent Effects of Itraconazole on the Pharmacokinetic Interaction with Fexofenadine

  Tsukasa Uno, Mikiko Shimizu, Kazunobu Sugawara and Tomonori Tateishi

  Drug Metabolism and Disposition November 2006, 34 (11) 1875-1879; DOI: https://doi.org/10.1124/dmd.106.011023
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  Metabolic Profile of FYX-051 (4-(5-Pyridin-4-yl-1H-[1,2,4]triazol-3-yl)pyridine-2-carbonitrile) in the Rat, Dog, Monkey, and Human: Identification of N-Glucuronides and N-Glucosides

  Takashi Nakazawa, Kengo Miyata, Koichi Omura, Takashi Iwanaga and Osamu Nagata

  Drug Metabolism and Disposition November 2006, 34 (11) 1880-1886; DOI: https://doi.org/10.1124/dmd.106.011692
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  Clofibrate Increases Hepatic Triiodothyronine (T₃)- and Thyroxine (T₄)-Glucuronosyltransferase Activities and Lowers Plasma T₃ and T₄ Concentrations in Pigs

  Sebastian Luci, Holger Kluge, Frank Hirche and Klaus Eder

  Drug Metabolism and Disposition November 2006, 34 (11) 1887-1892; DOI: https://doi.org/10.1124/dmd.106.011379
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  Innovative Methods to Study Human Intestinal Drug Metabolism in Vitro: Precision-Cut Slices Compared with Ussing Chamber Preparations

  Esther G. van de Kerkhof, Anna-Lena B. Ungell, Åsa K. Sjöberg, Marina H. de Jager, Constanze Hilgendorf, Inge A. M. de Graaf and Geny M. M. Groothuis

  Drug Metabolism and Disposition November 2006, 34 (11) 1893-1902; DOI: https://doi.org/10.1124/dmd.106.011148
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  Enzyme Source Effects on CYP2C9 Kinetics and Inhibition

  Vikas Kumar, Dan A. Rock, Chad J. Warren, Timothy S. Tracy and Jan L. Wahlstrom

  Drug Metabolism and Disposition November 2006, 34 (11) 1903-1908; DOI: https://doi.org/10.1124/dmd.106.010249
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  Disposition of [¹⁴C]Ruboxistaurin in Humans

  Jennifer L. Burkey, Kristina M. Campanale, Robert Barbuch, Douglas O'Bannon, James Rash, Charles Benson and David Small

  Drug Metabolism and Disposition November 2006, 34 (11) 1909-1917; DOI: https://doi.org/10.1124/dmd.106.009894
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  Pharmacokinetics, Metabolism, and Routes of Excretion of Intravenous Irofulven in Patients with Advanced Solid Tumors

  Angelo Paci, Keyvan Rezai, Alain Deroussent, Dominique De Valeriola, Micheline Re, Sophie Weill, Esteban Cvitkovic, Carmen Kahatt, Ajit Shah, Stephen Waters, Gary Weems, Gilles Vassal and François Lokiec

  Drug Metabolism and Disposition November 2006, 34 (11) 1918-1926; DOI: https://doi.org/10.1124/dmd.106.010512
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  PDZ Adaptor Protein PDZK2 Stimulates Transport Activity of Organic Cation/Carnitine Transporter OCTN2 by Modulating Cell Surface Expression

  Chizuru Watanabe, Yukio Kato, Tomoko Sugiura, Yoshiyuki Kubo, Tomohiko Wakayama, Shoichi Iseki and Akira Tsuji

  Drug Metabolism and Disposition November 2006, 34 (11) 1927-1934; DOI: https://doi.org/10.1124/dmd.106.010207
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  Porcine Brain Microvessel Endothelial Cells as an in Vitro Model to Predict in Vivo Blood-Brain Barrier Permeability

  Yan Zhang, Cheryl S. W. Li, Yuyang Ye, Kjell Johnson, Julie Poe, Shannon Johnson, Walter Bobrowski, Rosario Garrido and Cherukury Madhu

  Drug Metabolism and Disposition November 2006, 34 (11) 1935-1943; DOI: https://doi.org/10.1124/dmd.105.006437