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Research ArticleArticle

Innovative Methods to Study Human Intestinal Drug Metabolism in Vitro: Precision-Cut Slices Compared with Ussing Chamber Preparations

Esther G. van de Kerkhof, Anna-Lena B. Ungell, Åsa K. Sjöberg, Marina H. de Jager, Constanze Hilgendorf, Inge A. M. de Graaf and Geny M. M. Groothuis
Drug Metabolism and Disposition November 2006, 34 (11) 1893-1902; DOI: https://doi.org/10.1124/dmd.106.011148
Esther G. van de Kerkhof
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Anna-Lena B. Ungell
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Åsa K. Sjöberg
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Marina H. de Jager
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Constanze Hilgendorf
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Inge A. M. de Graaf
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Geny M. M. Groothuis
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Article Information

vol. 34 no. 11 1893-1902
DOI 
https://doi.org/10.1124/dmd.106.011148
PubMed 
16914511

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 23, 2006
  • Accepted August 10, 2006
  • Published online October 19, 2006.

Article Versions

  • Earlier version (August 16, 2006 - 07:49).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Esther G. van de Kerkhof,
  2. Anna-Lena B. Ungell,
  3. Åsa K. Sjöberg,
  4. Marina H. de Jager,
  5. Constanze Hilgendorf,
  6. Inge A. M. de Graaf and
  7. Geny M. M. Groothuis
  1. Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration, Groningen, The Netherlands (E.G.v.d.K., M.H.d.J., I.A.M.d.G., G.M.M.G.); and AstraZeneca, DMPK and Bioanalytical Chemistry, Mölndal, Sweden (A.-L.B.U., Å.K.S., C.H.)
  1. Address correspondence to:
    E.G. van de Kerkhof, Department of Pharmacokinetics & Drug Delivery, H. Deusinglaan 1, 9713 AV Groningen, The Netherlands. E-mail: e.g.van.de.kerkhof{at}rug.nl
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Drug Metabolism and Disposition: 34 (11)
Drug Metabolism and Disposition
Vol. 34, Issue 11
1 Nov 2006
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Research ArticleArticle

Innovative Methods to Study Human Intestinal Drug Metabolism in Vitro: Precision-Cut Slices Compared with Ussing Chamber Preparations

Esther G. van de Kerkhof, Anna-Lena B. Ungell, Åsa K. Sjöberg, Marina H. de Jager, Constanze Hilgendorf, Inge A. M. de Graaf and Geny M. M. Groothuis
Drug Metabolism and Disposition November 1, 2006, 34 (11) 1893-1902; DOI: https://doi.org/10.1124/dmd.106.011148

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Research ArticleArticle

Innovative Methods to Study Human Intestinal Drug Metabolism in Vitro: Precision-Cut Slices Compared with Ussing Chamber Preparations

Esther G. van de Kerkhof, Anna-Lena B. Ungell, Åsa K. Sjöberg, Marina H. de Jager, Constanze Hilgendorf, Inge A. M. de Graaf and Geny M. M. Groothuis
Drug Metabolism and Disposition November 1, 2006, 34 (11) 1893-1902; DOI: https://doi.org/10.1124/dmd.106.011148
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