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Drug Metabolism & Disposition

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Table of Contents

December 01, 2006; Volume 34,Issue 12

Short Communications

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    Influence of Hydroxyurea On Imatinib Mesylate (Gleevec) Transport at the Mouse Blood-Brain Barrier
    Sébastien Bihorel, Gian Camenisch, Gerhard Gross, Michel Lemaire and Jean-Michel Scherrmann
    Drug Metabolism and Disposition December 2006, 34 (12) 1945-1949; DOI: https://doi.org/10.1124/dmd.106.010975
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    Sulfinpyrazone C-Glucuronidation Is Catalyzed Selectively by Human UDP-Glucuronosyltransferase 1A9
    Oranun Kerdpin, David J. Elliot, Peter I. Mackenzie and John O. Miners
    Drug Metabolism and Disposition December 2006, 34 (12) 1950-1953; DOI: https://doi.org/10.1124/dmd.106.012385
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    Identification of Binding Sites of Non-I-Helix Water Molecules in Mammalian Cytochromes P450
    Charles W. Locuson and Timothy S. Tracy
    Drug Metabolism and Disposition December 2006, 34 (12) 1954-1957; DOI: https://doi.org/10.1124/dmd.106.011890

Articles

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    Engineering of Cytochrome P450 3A4 for Enhanced Peroxide-Mediated Substrate Oxidation Using Directed Evolution and Site-Directed Mutagenesis
    Santosh Kumar, Hong Liu and James R. Halpert
    Drug Metabolism and Disposition December 2006, 34 (12) 1958-1965; DOI: https://doi.org/10.1124/dmd.106.012054
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    CYP2C9 Inhibition: Impact of Probe Selection and Pharmacogenetics on in Vitro Inhibition Profiles
    Vikas Kumar, Jan L. Wahlstrom, Dan A. Rock, Chad J. Warren, Lee A. Gorman and Timothy S. Tracy
    Drug Metabolism and Disposition December 2006, 34 (12) 1966-1975; DOI: https://doi.org/10.1124/dmd.106.010926
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    Rapid Identification of P-glycoprotein Substrates and Inhibitors
    Cheng Chang, Praveen M. Bahadduri, James E. Polli, Peter W. Swaan and Sean Ekins
    Drug Metabolism and Disposition December 2006, 34 (12) 1976-1984; DOI: https://doi.org/10.1124/dmd.106.012351
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    CYP4F Enzymes Are the Major Enzymes in Human Liver Microsomes That Catalyze the O-Demethylation of the Antiparasitic Prodrug DB289 [2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime]
    Michael Zhuo Wang, Janelle Y. Saulter, Etsuko Usuki, Yen-Ling Cheung, Michael Hall, Arlene S. Bridges, Greg Loewen, Oliver T. Parkinson, Chad E. Stephens, James L. Allen, Darryl C. Zeldin, David W. Boykin, Richard R. Tidwell, Andrew Parkinson, Mary F. Paine and James Edwin Hall
    Drug Metabolism and Disposition December 2006, 34 (12) 1985-1994; DOI: https://doi.org/10.1124/dmd.106.010587
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    Investigation of Structure and Function of a Catalytically Efficient Variant of the Human Flavin-Containing Monooxygenase Form 3
    Tímea Borbás, Jun Zhang, Matt A. Cerny, István Likó and John R. Cashman
    Drug Metabolism and Disposition December 2006, 34 (12) 1995-2002; DOI: https://doi.org/10.1124/dmd.106.010827
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    Phenytoin Induction of the Cyp2c37 Gene Is Mediated by the Constitutive Androstane Receptor
    Jonathan P. Jackson, Stephen S. Ferguson, Masahiko Negishi and Joyce A. Goldstein
    Drug Metabolism and Disposition December 2006, 34 (12) 2003-2010; DOI: https://doi.org/10.1124/dmd.106.012005
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    Characterization of Human Urinary Metabolites of the Antimalarial Piperaquine
    J. Tarning, Y. Bergqvist, N. P. Day, J. Bergquist, B. Arvidsson, N. J. White, M. Ashton and N. Lindegårdh
    Drug Metabolism and Disposition December 2006, 34 (12) 2011-2019; DOI: https://doi.org/10.1124/dmd.106.011494
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    Comparative Metabolism and Disposition of Trichloroethylene in Cyp2e1–/–and Wild-Type Mice
    Dojung Kim and Burhan I. Ghanayem
    Drug Metabolism and Disposition December 2006, 34 (12) 2020-2027; DOI: https://doi.org/10.1124/dmd.106.010538
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    Pharmacokinetics and Metabolism in Mice of IDN 5390 (13-(N-Boc-3-i-butylisoserinoyl)-C-7,8-seco-10-deacetylbaccatin III), a New Oral C-seco-Taxane Derivative with Antiangiogenic Property Effective on Paclitaxel-Resistant Tumors
    R. Frapolli, E. Marangon, M. Zaffaroni, T. Colombo, C. Falcioni, R. Bagnati, M. Simone, M. D'Incalci, C. Manzotti, G. Fontana, P. Morazzoni and M. Zucchetti
    Drug Metabolism and Disposition December 2006, 34 (12) 2028-2035; DOI: https://doi.org/10.1124/dmd.106.012153
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    In Vivo Metabolism of l-Methionine in Mice: Evidence for Stereoselective Formation of Methionine-d-Sulfoxide and Quantitation of Other Major Metabolites
    Joseph T. Dever and Adnan A. Elfarra
    Drug Metabolism and Disposition December 2006, 34 (12) 2036-2043; DOI: https://doi.org/10.1124/dmd.106.012104
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    Metabolic Aromatization of N-Alkyl-1,2,3,4-Tetrahydroquinoline Substructures to Quinolinium by Human Liver Microsomes and Horseradish Peroxidase
    Chungang Gu, Roxane Collins, Daniel D. Holsworth, Gregory S. Walker and Richard L. Voorman
    Drug Metabolism and Disposition December 2006, 34 (12) 2044-2055; DOI: https://doi.org/10.1124/dmd.106.012286
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    Functional Analysis of Mouse and Monkey Multidrug Resistance-Associated Protein 2 (Mrp2)
    Mizuki Ninomiya, Kousei Ito, Remi Hiramatsu and Toshiharu Horie
    Drug Metabolism and Disposition December 2006, 34 (12) 2056-2063; DOI: https://doi.org/10.1124/dmd.106.010991
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    Pharmacokinetics of Berberine and Its Main Metabolites in Conventional and Pseudo Germ-Free Rats Determined by Liquid Chromatography/Ion Trap Mass Spectrometry
    Feng Zuo, Norio Nakamura, Teruaki Akao and Masao Hattori
    Drug Metabolism and Disposition December 2006, 34 (12) 2064-2072; DOI: https://doi.org/10.1124/dmd.106.011361
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    The Role of P-glycoprotein in the Bioactivation of Raloxifene
    Jae H. Chang, Christopher J. Kochansky and Magang Shou
    Drug Metabolism and Disposition December 2006, 34 (12) 2073-2078; DOI: https://doi.org/10.1124/dmd.106.012179
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    Drug-Metabolizing Enzyme Inhibition by Ketoconazole Does Not Reduce Interindividual Variability of CYP3A Activity as Measured by Oral Midazolam
    Maylee Chen, Anne N. Nafziger and Joseph S. Bertino
    Drug Metabolism and Disposition December 2006, 34 (12) 2079-2082; DOI: https://doi.org/10.1124/dmd.106.011742
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    Comparison of Coumarin-Induced Toxicity between Sandwich-Cultured Primary Rat Hepatocytes and Rats in Vivo: A Toxicogenomics Approach
    Anne S. Kienhuis, Heleen M. Wortelboer, Jean-Christophe Hoflack, Edwin J. Moonen, Jos C.S. Kleinjans, Ben van Ommen, Joost H. M. van Delft and Rob H. Stierum
    Drug Metabolism and Disposition December 2006, 34 (12) 2083-2090; DOI: https://doi.org/10.1124/dmd.106.011262
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    Rofecoxib Is a Potent, Metabolism-Dependent Inhibitor of CYP1A2: Implications for in Vitro Prediction of Drug Interactions
    Marjo J. Karjalainen, Pertti J. Neuvonen and Janne T. Backman
    Drug Metabolism and Disposition December 2006, 34 (12) 2091-2096; DOI: https://doi.org/10.1124/dmd.106.011965
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    Epirubicin Glucuronidation and UGT2B7 Developmental Expression
    Matthew J. Zaya, Ronald N. Hines and Jeffrey C. Stevens
    Drug Metabolism and Disposition December 2006, 34 (12) 2097-2101; DOI: https://doi.org/10.1124/dmd.106.011387
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    Structure-Activity Relationship and Elucidation of the Determinant Factor(s) Responsible for the Mechanism-Based Inactivation of Cytochrome P450 2B6 by Substituted Phenyl Diaziridines
    Yoshimasa Kobayashi, Chitra Sridar, Ute M. Kent, Satish G. Puppali, John M. Rimoldi, Haoming Zhang, Lucy Waskell and Paul F. Hollenberg
    Drug Metabolism and Disposition December 2006, 34 (12) 2102-2110; DOI: https://doi.org/10.1124/dmd.106.011452
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    Peracetylation as a Means of Enhancing in Vitro Bioactivity and Bioavailability of Epigallocatechin-3-Gallate
    Joshua D. Lambert, Shengmin Sang, Jungil Hong, Seok-Joo Kwon, Mao-Jung Lee, Chi-Tang Ho and Chung S. Yang
    Drug Metabolism and Disposition December 2006, 34 (12) 2111-2116; DOI: https://doi.org/10.1124/dmd.106.011460

Erratum

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    CORRECTION TO “NEUROTOXIC PYRIDINIUM METABOLITES OF HALOPERIDOL ARE SUBSTRATES OF HUMAN ORGANIC CATION TRANSPORTERS”
    Drug Metabolism and Disposition December 2006, 34 (12) 2117; DOI: https://doi.org/10.1124/dmd.34.12.2117
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In this issue

Drug Metabolism and Disposition: 34 (12)
Drug Metabolism and Disposition
Vol. 34, Issue 12
1 Dec 2006
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
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  • Short Communications
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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