Table of Contents

Articles

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  Engineering of Cytochrome P450 3A4 for Enhanced Peroxide-Mediated Substrate Oxidation Using Directed Evolution and Site-Directed Mutagenesis

  Santosh Kumar, Hong Liu and James R. Halpert

  Drug Metabolism and Disposition December 2006, 34 (12) 1958-1965; DOI: https://doi.org/10.1124/dmd.106.012054
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  CYP2C9 Inhibition: Impact of Probe Selection and Pharmacogenetics on in Vitro Inhibition Profiles

  Vikas Kumar, Jan L. Wahlstrom, Dan A. Rock, Chad J. Warren, Lee A. Gorman and Timothy S. Tracy

  Drug Metabolism and Disposition December 2006, 34 (12) 1966-1975; DOI: https://doi.org/10.1124/dmd.106.010926
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  Rapid Identification of P-glycoprotein Substrates and Inhibitors

  Cheng Chang, Praveen M. Bahadduri, James E. Polli, Peter W. Swaan and Sean Ekins

  Drug Metabolism and Disposition December 2006, 34 (12) 1976-1984; DOI: https://doi.org/10.1124/dmd.106.012351
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  CYP4F Enzymes Are the Major Enzymes in Human Liver Microsomes That Catalyze the O-Demethylation of the Antiparasitic Prodrug DB289 [2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime]

  Michael Zhuo Wang, Janelle Y. Saulter, Etsuko Usuki, Yen-Ling Cheung, Michael Hall, Arlene S. Bridges, Greg Loewen, Oliver T. Parkinson, Chad E. Stephens, James L. Allen, Darryl C. Zeldin, David W. Boykin, Richard R. Tidwell, Andrew Parkinson, Mary F. Paine and James Edwin Hall

  Drug Metabolism and Disposition December 2006, 34 (12) 1985-1994; DOI: https://doi.org/10.1124/dmd.106.010587
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  Investigation of Structure and Function of a Catalytically Efficient Variant of the Human Flavin-Containing Monooxygenase Form 3

  Tímea Borbás, Jun Zhang, Matt A. Cerny, István Likó and John R. Cashman

  Drug Metabolism and Disposition December 2006, 34 (12) 1995-2002; DOI: https://doi.org/10.1124/dmd.106.010827
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  Phenytoin Induction of the Cyp2c37 Gene Is Mediated by the Constitutive Androstane Receptor

  Jonathan P. Jackson, Stephen S. Ferguson, Masahiko Negishi and Joyce A. Goldstein

  Drug Metabolism and Disposition December 2006, 34 (12) 2003-2010; DOI: https://doi.org/10.1124/dmd.106.012005
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  Characterization of Human Urinary Metabolites of the Antimalarial Piperaquine

  J. Tarning, Y. Bergqvist, N. P. Day, J. Bergquist, B. Arvidsson, N. J. White, M. Ashton and N. Lindegårdh

  Drug Metabolism and Disposition December 2006, 34 (12) 2011-2019; DOI: https://doi.org/10.1124/dmd.106.011494
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  Comparative Metabolism and Disposition of Trichloroethylene in Cyp2e1–/–and Wild-Type Mice

  Dojung Kim and Burhan I. Ghanayem

  Drug Metabolism and Disposition December 2006, 34 (12) 2020-2027; DOI: https://doi.org/10.1124/dmd.106.010538
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  Pharmacokinetics and Metabolism in Mice of IDN 5390 (13-(N-Boc-3-i-butylisoserinoyl)-C-7,8-seco-10-deacetylbaccatin III), a New Oral C-seco-Taxane Derivative with Antiangiogenic Property Effective on Paclitaxel-Resistant Tumors

  R. Frapolli, E. Marangon, M. Zaffaroni, T. Colombo, C. Falcioni, R. Bagnati, M. Simone, M. D'Incalci, C. Manzotti, G. Fontana, P. Morazzoni and M. Zucchetti

  Drug Metabolism and Disposition December 2006, 34 (12) 2028-2035; DOI: https://doi.org/10.1124/dmd.106.012153
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  In Vivo Metabolism of l-Methionine in Mice: Evidence for Stereoselective Formation of Methionine-d-Sulfoxide and Quantitation of Other Major Metabolites

  Joseph T. Dever and Adnan A. Elfarra

  Drug Metabolism and Disposition December 2006, 34 (12) 2036-2043; DOI: https://doi.org/10.1124/dmd.106.012104
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  Metabolic Aromatization of N-Alkyl-1,2,3,4-Tetrahydroquinoline Substructures to Quinolinium by Human Liver Microsomes and Horseradish Peroxidase

  Chungang Gu, Roxane Collins, Daniel D. Holsworth, Gregory S. Walker and Richard L. Voorman

  Drug Metabolism and Disposition December 2006, 34 (12) 2044-2055; DOI: https://doi.org/10.1124/dmd.106.012286
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  Functional Analysis of Mouse and Monkey Multidrug Resistance-Associated Protein 2 (Mrp2)

  Mizuki Ninomiya, Kousei Ito, Remi Hiramatsu and Toshiharu Horie

  Drug Metabolism and Disposition December 2006, 34 (12) 2056-2063; DOI: https://doi.org/10.1124/dmd.106.010991
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  Pharmacokinetics of Berberine and Its Main Metabolites in Conventional and Pseudo Germ-Free Rats Determined by Liquid Chromatography/Ion Trap Mass Spectrometry

  Feng Zuo, Norio Nakamura, Teruaki Akao and Masao Hattori

  Drug Metabolism and Disposition December 2006, 34 (12) 2064-2072; DOI: https://doi.org/10.1124/dmd.106.011361
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  The Role of P-glycoprotein in the Bioactivation of Raloxifene

  Jae H. Chang, Christopher J. Kochansky and Magang Shou

  Drug Metabolism and Disposition December 2006, 34 (12) 2073-2078; DOI: https://doi.org/10.1124/dmd.106.012179
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  Drug-Metabolizing Enzyme Inhibition by Ketoconazole Does Not Reduce Interindividual Variability of CYP3A Activity as Measured by Oral Midazolam

  Maylee Chen, Anne N. Nafziger and Joseph S. Bertino

  Drug Metabolism and Disposition December 2006, 34 (12) 2079-2082; DOI: https://doi.org/10.1124/dmd.106.011742
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  Comparison of Coumarin-Induced Toxicity between Sandwich-Cultured Primary Rat Hepatocytes and Rats in Vivo: A Toxicogenomics Approach

  Anne S. Kienhuis, Heleen M. Wortelboer, Jean-Christophe Hoflack, Edwin J. Moonen, Jos C.S. Kleinjans, Ben van Ommen, Joost H. M. van Delft and Rob H. Stierum

  Drug Metabolism and Disposition December 2006, 34 (12) 2083-2090; DOI: https://doi.org/10.1124/dmd.106.011262
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  Rofecoxib Is a Potent, Metabolism-Dependent Inhibitor of CYP1A2: Implications for in Vitro Prediction of Drug Interactions

  Marjo J. Karjalainen, Pertti J. Neuvonen and Janne T. Backman

  Drug Metabolism and Disposition December 2006, 34 (12) 2091-2096; DOI: https://doi.org/10.1124/dmd.106.011965
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  Epirubicin Glucuronidation and UGT2B7 Developmental Expression

  Matthew J. Zaya, Ronald N. Hines and Jeffrey C. Stevens

  Drug Metabolism and Disposition December 2006, 34 (12) 2097-2101; DOI: https://doi.org/10.1124/dmd.106.011387
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  Structure-Activity Relationship and Elucidation of the Determinant Factor(s) Responsible for the Mechanism-Based Inactivation of Cytochrome P450 2B6 by Substituted Phenyl Diaziridines

  Yoshimasa Kobayashi, Chitra Sridar, Ute M. Kent, Satish G. Puppali, John M. Rimoldi, Haoming Zhang, Lucy Waskell and Paul F. Hollenberg

  Drug Metabolism and Disposition December 2006, 34 (12) 2102-2110; DOI: https://doi.org/10.1124/dmd.106.011452
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  Peracetylation as a Means of Enhancing in Vitro Bioactivity and Bioavailability of Epigallocatechin-3-Gallate

  Joshua D. Lambert, Shengmin Sang, Jungil Hong, Seok-Joo Kwon, Mao-Jung Lee, Chi-Tang Ho and Chung S. Yang

  Drug Metabolism and Disposition December 2006, 34 (12) 2111-2116; DOI: https://doi.org/10.1124/dmd.106.011460