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(Methionine-)Tj
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[0.3 (d)]TJ
/T1_0 1 Tf
[(-Sulfoxide)-953.1 (and)-953.1 (Quantitation)-953.1 (of)]TJ
0 -1.1 TD
[(Other)-429.8 (Major)-429.8 (Metabolites.)-429.8 (J)]TJ
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(OSEPH)Tj
10 0 0 10 193.3412 709.8835 Tm
[(T.)-429.8 (D)]TJ
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[(EVER)-614.1 (AND)]TJ
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(A)Tj
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(DNAN)Tj
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[(A.)-316.2 (E)]TJ
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(LFARRA)Tj
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(....................)Tj
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(2036)Tj
/T1_0 1 Tf
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[(Metabolic)-266.7 (Aromatization)-266.7 (of)]TJ
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11.4646 0 Td
(N)Tj
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(-Alkyl-1,2,3,4-Tetrahy-)Tj
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[(droquinoline)-589.5 (Substructures)-589.5 (to)-589.5 (Quinolinium)-589.4 (by)]TJ
T*
[(Human)-361.3 (Liver)-361.3 (Microsomes)-361.3 (and)-361.3 (Horseradish)-361.3 (Per-)]TJ
T*
[(oxidase.)-295.2 (C)]TJ
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(HUNGANG)Tj
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(G)Tj
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(U)Tj
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(,R)Tj
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(OXANE)Tj
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(C)Tj
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(,D)Tj
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(ANIEL)Tj
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[(D.)-386.6 (H)]TJ
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(OLSWORTH)Tj
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(,G)Tj
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[(S.)-386.6 (W)]TJ
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(,)Tj
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(AND)Tj
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(R)Tj
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(ICH)Tj
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(-)Tj
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(ARD)Tj
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[(L.)-316.2 (V)]TJ
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(OORMAN)Tj
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(.....................)Tj
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(2044)Tj
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(\001)Tj
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(S)Tj
10 0 0 10 35.1656 601.8835 Tm
[(Functional)-239.5 (Analysis)-239.5 (of)-239.5 (Mouse)-239.5 (and)-239.5 (Monkey)-239.5 (Multidrug)]TJ
1.7999 -1.1 Td
[(Resistance-Associated)-371.3 (Protein)-371.3 (2)-371.3 (\(Mrp2\).)-371.3 (M)]TJ
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(IZUKI)Tj
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(N)Tj
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(INOMIYA)Tj
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(,K)Tj
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(OUSEI)Tj
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(I)Tj
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(TO)Tj
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(,R)Tj
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(EMI)Tj
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(H)Tj
7 0 0 7 190.3539 579.8835 Tm
(IRAMATSU)Tj
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(,)Tj
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(AND)Tj
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(T)Tj
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(OSHIHARU)Tj
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(H)Tj
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(ORIE)Tj
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(.....................)Tj
/T1_2 1 Tf
0 Tc 13.4044 0 Td
(2056)Tj
/T1_0 1 Tf
10 0 0 10 35.1648 547.8835 Tm
[(Pharmacokinetics)-295.4 (of)-295.4 (Berberine)-295.4 (and)-295.4 (Its)-295.4 (Main)-295.4 (Metabo-)]TJ
1.8 -1.1 Td
[(lites)-245.1 (in)-245.1 (Conventional)-245.2 (and)-245.1 (Pseudo)-245.1 (Germ-Free)-245.1 (Rats)]TJ
T*
[(Determined)-284.3 (by)-284.3 (Liquid)-284.3 (Chromatography/Ion)-284.3 (Trap)]TJ
T*
[(Mass)-234.1 (Spectrometry.)-234.1 (F)]TJ
7 0 0 7 140.8915 514.8835 Tm
(ENG)Tj
10 0 0 10 157.6177 514.8835 Tm
(Z)Tj
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(UO)Tj
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(,N)Tj
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(ORIO)Tj
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(N)Tj
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(AKAMURA)Tj
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(,)Tj
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(T)Tj
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(ERUAKI)Tj
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(A)Tj
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(KAO)Tj
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(,)Tj
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(AND)Tj
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(M)Tj
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(ASAO)Tj
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(H)Tj
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(ATTORI)Tj
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(........)Tj
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(2064)Tj
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[(The)-451.1 (Role)-451.1 (of)-451.1 (P-glycoprotein)-451.1 (in)-451.1 (the)-451.1 (Bioactivation)-451.1 (of)]TJ
1.8 -1.1 Td
[(Raloxifene.)-862.5 (J)]TJ
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(AE)Tj
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[(H.)-862.5 (C)]TJ
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(HANG)Tj
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(,C)Tj
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(J.)Tj
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(K)Tj
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(OCHANSKY)Tj
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(,)Tj
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(AND)Tj
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(S)Tj
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(HOU)Tj
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(...........)Tj
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(2073)Tj
/T1_0 1 Tf
10 0 0 10 35.1648 439.8835 Tm
[(Drug-Metabolizing)-484.3 (Enzyme)-484.3 (Inhibition)-484.3 (by)-484.3 (Ketocon-)]TJ
1.8 -1.1 Td
[(azole)-316.7 (Does)-316.7 (Not)-316.7 (Reduce)-316.7 (Interindividual)-316.7 (Variabil-)]TJ
T*
[(ity)-559.3 (of)-559.4 (CYP3A)-559.3 (Activity)-559.3 (as)-559.4 (Measured)-559.3 (by)-559.3 (Oral)]TJ
T*
[(Midazolam.)-480.4 (M)]TJ
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(AYLEE)Tj
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(C)Tj
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(HEN)Tj
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(,A)Tj
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[(N.)-480.4 (N)]TJ
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(AFZIGER)Tj
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(,)Tj
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(AND)Tj
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(J)Tj
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(OSEPH)Tj
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[(S.)-316.2 (B)]TJ
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(ERTINO)Tj
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(,J)Tj
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(R)Tj
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(.)Tj
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(...............)Tj
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(2079)Tj
/T1_0 1 Tf
10 0 0 10 35.1648 374.8835 Tm
[(Comparison)-401.1 (of)-401.1 (Coumarin-Induced)-401.1 (Toxicity)-401.1 (between)]TJ
1.8 -1.1 Td
[(Sandwich-Cultured)-256.8 (Primary)-256.8 (Rat)-256.8 (Hepatocytes)-256.8 (and)]TJ
T*
[(Rats)-677.2 (in)-677.2 (Vivo:)-677.3 (A)-677.2 (Toxicogenomics)-677.2 (Approach.)]TJ
28.3 36.8 Td
(A)Tj
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(NNE)Tj
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[(S.)-252.5 (K)]TJ
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(IENHUIS)Tj
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(,H)Tj
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(ELEEN)Tj
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[(M.)-252.6 (W)]TJ
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(ORTELBOER)Tj
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(,J)Tj
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(EAN)Tj
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(C)Tj
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(HRISTOPHE)Tj
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(H)Tj
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(OFLACK)Tj
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(,E)Tj
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(DWIN)Tj
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[(J.)-294.9 (M)]TJ
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(OONEN)Tj
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(,J)Tj
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(OS)Tj
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(C.S.)Tj
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(K)Tj
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(,B)Tj
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[(EN)-705.8 (VAN)]TJ
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(O)Tj
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(,J)Tj
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(OOST)Tj
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[(H.)-494.1 (M.)]TJ
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(D)Tj
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(OB)Tj
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(..............)Tj
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(2083)Tj
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[(Rofecoxib)-315.6 (Is)-315.6 (a)-315.6 (Potent,)-315.6 (Metabolism-Dependent)-315.6 (Inhib-)]TJ
1.8 -1.1 Td
[(itor)-416.5 (of)-416.5 (CYP1A2:)-416.5 (Implications)-416.5 (for)-416.5 (in)-416.4 (Vitro)-416.5 (Pre-)]TJ
T*
[(diction)-643.4 (of)-643.4 (Drug)-643.4 (Interactions.)-643.5 (M)]TJ
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(ARJO)Tj
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[(J.)-643.5 (K)]TJ
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(AR)Tj
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(-)Tj
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(JALAINEN)Tj
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(,P)Tj
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(ERTTI)Tj
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[(J.)-655.4 (N)]TJ
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(EUVONEN)Tj
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(,)Tj
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(AND)Tj
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(J)Tj
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(ANNE)Tj
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(T.)Tj
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(B)Tj
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(ACKMAN)Tj
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(..........................)Tj
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(2091)Tj
/T1_0 1 Tf
10 0 0 10 318.1648 605.1449 Tm
[(Epirubicin)-484.3 (Glucuronidation)-484.3 (and)-484.3 (UGT2B7)-484.3 (Develop-)]TJ
1.8 -1.1 Td
[(mental)-240 (Expression.)-240 (M)]TJ
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(ATTHEW)Tj
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[(J.)-240 (Z)]TJ
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(AYA)Tj
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(,R)Tj
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(ONALD)Tj
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(N.)Tj
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(H)Tj
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(INES)Tj
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(,)Tj
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(AND)Tj
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(J)Tj
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(EFFREY)Tj
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[(C.)-316.2 (S)]TJ
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(TEVENS)Tj
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(............)Tj
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(2097)Tj
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[(Structure-Activity)-420.1 (Relationship)-420.1 (and)-420.1 (Elucidation)-420.1 (of)-420.2 (the)]TJ
1.8 -1.1 Td
[(Determinant)-337.2 (Factor\(s\))-337.2 (Responsible)-337.2 (for)-337.2 (the)-337.2 (Mecha-)]TJ
T*
[(nism-Based)-317.6 (Inactivation)-317.6 (of)-317.6 (Cytochrome)-317.6 (P450)-317.6 (2B6)]TJ
T*
[(by)-698.5 (Substituted)-698.5 (Phenyl)-698.6 (Diaziridines.)-698.6 (Y)]TJ
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(OSHIMASA)Tj
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(K)Tj
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(OBAYASHI)Tj
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(,C)Tj
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(HITRA)Tj
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(S)Tj
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(RIDAR)Tj
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(,U)Tj
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(TE)Tj
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[(M.)-225.4 (K)]TJ
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(ENT)Tj
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(,S)Tj
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(ATISH)Tj
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(G.)Tj
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(P)Tj
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(UPPALI)Tj
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(,J)Tj
-0.028 Tc 7 0 0 7 374.5804 508.7812 Tm
(OHN)Tj
-0.0197 Tc 10 0 0 10 392.8847 508.7812 Tm
[(M.)-373.1 (R)]TJ
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(IMOLDI)Tj
0.35339 Tc 10 0 0 10 438.1799 508.7812 Tm
(,H)Tj
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(AOMING)Tj
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(Z)Tj
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(HANG)Tj
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(,L)Tj
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(UCY)Tj
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(W)Tj
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(ASKELL)Tj
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(,)Tj
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(AND)Tj
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(P)Tj
-0.028 Tc 7 0 0 7 399.629 497.7813 Tm
(AUL)Tj
-0.01961 Tc 10 0 0 10 416.5881 497.7813 Tm
[(F.)-316.2 (H)]TJ
-0.028 Tc 7 0 0 7 434.441 497.7813 Tm
(OLLENBERG)Tj
0.38161 Tc 9.5 0 0 9.5 477.8481 497.7813 Tm
(..........)Tj
/T1_2 1 Tf
0 Tc 6.4544 0 Td
(2102)Tj
/T1_0 1 Tf
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[(Peracetylation)-562.8 (as)-562.8 (a)-562.8 (M)0.1 (eans)-562.8 (of)-562.8 (Enhancing)-562.8 (in)-562.8 (Vitro)]TJ
1.8 -1.1 Td
[(Bioactivity)-561.9 (and)-561.9 (Bioavailability)-561.9 (of)-561.9 (Epigallocat-)]TJ
T*
[(echin-3-Gallate.)-481.5 (J)]TJ
7 0 0 7 409.5659 456.4176 Tm
(OSHUA)Tj
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