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Research ArticleArticle

Engineering of Cytochrome P450 3A4 for Enhanced Peroxide-Mediated Substrate Oxidation Using Directed Evolution and Site-Directed Mutagenesis

Santosh Kumar, Hong Liu and James R. Halpert
Drug Metabolism and Disposition December 2006, 34 (12) 1958-1965; DOI: https://doi.org/10.1124/dmd.106.012054

Article Information

vol. 34 no. 12 1958-1965
DOI 
https://doi.org/10.1124/dmd.106.012054
PubMed 
16987939
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 17, 2006
  • Accepted September 13, 2006
  • Published online November 29, 2006.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Santosh Kumar,
  2. Hong Liu and
  3. James R. Halpert
  1. Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas (S.K., J.R.H.); and the Center for Drug Discovery and Design, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (H.L.)
  1. Address correspondence to:
    Santosh Kumar, Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1031. E-mail: sakumar{at}utmb.edu
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Research ArticleArticle

Engineering of Cytochrome P450 3A4 for Enhanced Peroxide-Mediated Substrate Oxidation Using Directed Evolution and Site-Directed Mutagenesis

Santosh Kumar, Hong Liu and James R. Halpert
Drug Metabolism and Disposition December 1, 2006, 34 (12) 1958-1965; DOI: https://doi.org/10.1124/dmd.106.012054
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